13 research outputs found
Meta-analysis of GSTT1 null genotype associated with HCC.
<p>Meta-analysis of GSTT1 null genotype associated with HCC.</p
Forest plot for association of dual null genotype of GSTM1/GSTT1 and HCC risk.
<p>Forest plot for association of dual null genotype of GSTM1/GSTT1 and HCC risk.</p
Genetic Polymorphisms of Glutathione S-Transferase Genes GSTM1, GSTT1 and Risk of Hepatocellular Carcinoma
<div><h3>Background</h3><p>A number of case-control studies were conducted to investigate the association of glutathione S-transferase (GST) genetic polymorphisms and hepatocellular carcinoma (HCC) risk. However, these studies have yielded contradictory results. We therefore performed a meta-analysis to derive a more precise estimation of the association between polymorphisms on GSTM1, GSTT1 and HCC.</p> <h3>Methodology/Prinicpal Findings</h3><p>PubMed, EMBASE, ISI web of science and the CNKI databases were systematically searched to identify relevant studies. Data were abstracted independently by two reviewers. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to assess the strength of association. Potential sources of heterogeneity were also assessed by subgroup analysis and meta-regression. Funnel plots and Eggerβs linear regression were used to test publication bias among the articles. A total of 34 studies including 4,463 cases and 6,857 controls were included in this meta-analysis. In a combined analysis, significantly increased HCC risks were found for null genotype of GSTM1 (ORβ=β1.29, 95% CI: 1.06β1.58; Pβ=β0.01) and GSTT1 (ORβ=β1.43, 95% CI: 1.22β1.68; P<10<sup>β5</sup>). Potential sources of heterogeneity were explored by subgroup analysis and meta-regression. Significant results were found in East Asians and Indians when stratified by ethnicity; whereas no significant associations were found among Caucasians and African populations. By pooling data from 12 studies that considered combinations of GSTT1 and GSTM1 null genotypes, a statistically significant increased risk for HCC (ORβ=β1.88, 95% CI: 1.41β2.50; P<10<sup>β4</sup>) was detected for individuals with combined deletion mutations in both genes compared with positive genotypes.</p> <h3>Conclusions/Significance</h3><p>This meta-analysis suggests that the GSTM1 and GSTT1 null genotype may slightly increase the risk of HCC and that interaction between unfavourable GSTs genotypes may exist.</p> </div
Genetic Analysis of the Relationship between Bone Mineral Density and Low-Density Lipoprotein Receptor-Related Protein 5 Gene Polymorphisms
<div><p>Background</p><p>A number of studies have examined the association between the polymorphisms of the low-density lipoprotein receptor-related protein 5 gene (LRP5), but previous results have been inconclusive. Thus we performed a meta-analysis of studies on the association between the LRP5 polymorphisms and bone mineral density (BMD) to assess their pooled effects.</p> <p>Methods</p><p>Published literature from PubMed, EMBASE and ISI web of science were searched for eligible publications. Weighted mean difference (WMD) and 95% confidence interval (CI) was calculated using fixed- or random-effects model.</p> <p>Results</p><p>A total of 19 studies with 25773 subjects were considered in this meta-analysis. Of them, 17 examined the association between the A1330V polymorphism and BMD, 8 were focused on the V667M polymorphism, and 2 analyzed the Q89R polymorphism. Individuals with the A1330V AA genotype showed significantly higher BMD than those with the AV/VV genotypes [at lumbar spine (LS): WMD = 0.02g/cm<sup>2</sup>, 95% CI = 0.01-0.03, <i>P</i> < 10<sup>-4</sup>; at femur neck (FN): WMD = 0.01g/cm<sup>2</sup>, 95% CI = 0.00-0.02, <i>P</i> = 0.01] or VV genotype (at LS: WMD = 0.02g/cm<sup>2</sup>, 95% CI = 0.01-0.04, <i>P</i> = 0.01). Significant associations were also detected in the analysis for V667M (VV vs. VM/MM: WMD at LS = 0.02g/cm<sup>2</sup>, 95% CI = 0.02-0.03, <i>P</i> < 10<sup>-5</sup>; WMD at FN = 0.01g/cm<sup>2</sup>, 95% CI = 0.01-0.02, <i>P</i> = 0.0002). As for Q89R, subjects with the QQ genotype tended to have higher BMD than those with the QR/RR genotypes at FN (WMD = 0.03g/cm<sup>2</sup>, 95% CI = 0.01-0.05, <i>P</i> = 0.005).</p> <p>Conclusion</p><p>This meta-analysis demonstrated that the <i>LRP5</i> polymorphisms may be modestly associated with BMD of LS and FN.</p> </div
Meta-analysis of GSTM1 null genotype associated with HCC.
<p>Meta-analysis of GSTM1 null genotype associated with HCC.</p
Main results of pooled odds ratios (ORs) with confidence interval (CI) in the meta-analysis.
<p>Main results of pooled odds ratios (ORs) with confidence interval (CI) in the meta-analysis.</p
WMD and 95% CI in LS BMD between A1330V AA and AV/VV genotypes.
<p>WMD and 95% CI in LS BMD between A1330V AA and AV/VV genotypes.</p
WMD and 95% CI in LS BMD between V667M VV and VM/MM genotypes.
<p>WMD and 95% CI in LS BMD between V667M VV and VM/MM genotypes.</p
WMD and 95% CI in FN BMD between Q89R QQ and QR/RR genotypes.
<p>WMD and 95% CI in FN BMD between Q89R QQ and QR/RR genotypes.</p