Palladium(II)-Catalyzed Enantioselective Arylation of α‑Imino Esters

A protocol for Pd­(II)-catalyzed asymmetric arylation of <i>N</i>-aryl imino esters has been developed. The method affords a practical and direct access to chiral arylglycine derivatives in good yields and with high enantioselectivities

Siteselective and Enantiocomplementary C(sp³)–H Oxyfunctionalization for Synthesis of α‑Hydroxy Acids

Oxyfunctionalization of abundant carboxylic acids represents a direct approach to synthesizing α-hydroxy acids, which are valuable intermediates of various active pharmaceutical ingredients. Although ideal, the transformation is yet to be accomplished. Herein, enantiocomplementary C(sp3)–H oxyfunctionalization for the synthesis of α-hydroxy acids was realized by a cooperative strategy of substrate engineering, homologue screening and protein engineering of α-ketoglutarate-dependent nonheme iron aryloxyalkanoate dioxygenases. The reaction provided concise synthetic routes toward three types of 67 α-hydroxy acids with high efficiency and selectivity (yield up to 90% and ee up to >99%). The distinctive complementary reactions add to a growing repertoire of biocatalytic oxyfunctionalization reactions

sj-docx-1-tam-10.1177_17588359231225036 – Supplemental material for Efficacy of immunotherapy in patients with oncogene-driven non-small-cell lung cancer: a systematic review and meta-analysis

Supplemental material, sj-docx-1-tam-10.1177_17588359231225036 for Efficacy of immunotherapy in patients with oncogene-driven non-small-cell lung cancer: a systematic review and meta-analysis by Jiayan Chen, Wanjun Lu, Mo Chen, Zijing Cai, Ping Zhan, Xin Liu, Suhua Zhu, Mingxiang Ye, Tangfeng Lv, Jiawen Lv, Yong Song and Dong Wang in Therapeutic Advances in Medical Oncology</p

sj-docx-2-tam-10.1177_17588359231225036 – Supplemental material for Efficacy of immunotherapy in patients with oncogene-driven non-small-cell lung cancer: a systematic review and meta-analysis

Supplemental material, sj-docx-2-tam-10.1177_17588359231225036 for Efficacy of immunotherapy in patients with oncogene-driven non-small-cell lung cancer: a systematic review and meta-analysis by Jiayan Chen, Wanjun Lu, Mo Chen, Zijing Cai, Ping Zhan, Xin Liu, Suhua Zhu, Mingxiang Ye, Tangfeng Lv, Jiawen Lv, Yong Song and Dong Wang in Therapeutic Advances in Medical Oncology</p

sj-docx-3-tam-10.1177_17588359231225036 – Supplemental material for Efficacy of immunotherapy in patients with oncogene-driven non-small-cell lung cancer: a systematic review and meta-analysis

Supplemental material, sj-docx-3-tam-10.1177_17588359231225036 for Efficacy of immunotherapy in patients with oncogene-driven non-small-cell lung cancer: a systematic review and meta-analysis by Jiayan Chen, Wanjun Lu, Mo Chen, Zijing Cai, Ping Zhan, Xin Liu, Suhua Zhu, Mingxiang Ye, Tangfeng Lv, Jiawen Lv, Yong Song and Dong Wang in Therapeutic Advances in Medical Oncology</p

Metabolic Susceptibility of 2‑Chlorothioxanthone and Its Toxic Effects on mRNA and Protein Expression and Activities of Human CYP1A2 and CYP3A4 Enzymes

Thioxanthones (TXs) are photoinitiators widely used in UV curable resins and food packaging, and their residues have been frequently detected in human bodies. Our current understanding of the susceptibility of residual TXs to metabolism and their effects on human health is very limited. The in vitro metabolism of TXs and its toxic effects on cytochrome P450 (CYP) (the key xenobiotic metabolizing enzymes) were examined in this study. 2-Chlorothioxanthone (2-Cl-TX) significantly inhibited the enzymatic activities of CYP1A2 and CYP3A4 with IC50 of 8.36 and 0.86 μM, respectively. The exposure to 2-Cl-TX at 2.5 μM up-regulated the mRNA expression of CYP1A2 and CYP3A4 in human hepatocellular carcinoma cells to 3.03-fold and 2.02-fold, respectively. 2-Cl-TX at 2.5 μM caused 2.19-fold and 1.98-fold overexpression of CYP1A2 and CYP3A4, respectively. In vitro studies revealed that 2-Cl-TX was biotransformed into two metabolites through the sulfoxidation of the sulfur atom, or via the hydroxylation of aromatic carbon. Results from this study, including the metabolic susceptibility of residual 2-Cl-TX, the proposed metabolites and the significant toxic effect on the activities, mRNA, and protein expression of CYP1A2 and CYP3A4, are vital to the human health and safety risk assessment from this ubiquitous xenobiotic

Additional file 1 of Obstacles to access to community care in urban senior-only households: a qualitative study

Additional file 1

Additional file 1 of Ubiquitin ligase subunit FBXO9 inhibits V-ATPase assembly and impedes lung cancer metastasis

Supplementary Material

sj-docx-1-tam-10.1177_17588359211054895 – Supplemental material for Comprehensive analysis of prognostic value of lymph node classifications in esophageal squamous cell carcinoma: a large real-world multicenter study

Supplemental material, sj-docx-1-tam-10.1177_17588359211054895 for Comprehensive analysis of prognostic value of lymph node classifications in esophageal squamous cell carcinoma: a large real-world multicenter study by Junmiao Wen, Jiayan Chen, Donglai Chen, Salma K. Jabbour, Tao Xue, Xufeng Guo, Haitao Ma, Fei Ye, Yiming Mao, Jian Shu, Yangyang Liu, Xueguan Lu, Zhen Zhang, Yongbing Chen and Min Fan in Therapeutic Advances in Medical Oncology</p