3 research outputs found

    Image_1_Preoperative plasma fibrinogen and C-reactive protein/albumin ratio as prognostic biomarkers for pancreatic carcinoma.pdf

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    ObjectivePancreatic carcinoma is characterised by high aggressiveness and a bleak prognosis; optimising related treatment decisions depends on the availability of reliable prognostic markers. This study was designed to compare various blood biomarkers, such as neutrophil/lymphocyte ratio (NLR), lymphocyte/monocyte ratio (LMR), platelet/lymphocyte ratio (PLR), C-reactive protein (CRP), albumin (Alb), plasma fibrinogen (PF), and CRP/Alb in patients with pancreatic carcinoma.MethodsOur study retrospectively reviewed 250 patients with pancreatic carcinoma diagnosed between July 2007 and December 2018. The Cutoff Finder application was used to calculate the optimal values of CRP/Alb and PF. The Chi-square test or Fisher’s exact test was used to analyse the correlation of CRP/Alb and PF with other clinicopathological factors. Conducting univariate and multivariate analyses allowed further survival analysis of these prognostic factors.ResultsMultivariate analysis revealed that, in a cohort of 232 patients with pancreatic ductal adenocarcinoma (PDAC), the PF level exhibited statistical significance for overall survival (hazard ratio (HR) = 0.464; p = 0.023); however, this correlation was not found in the entire group of 250 patients with pancreatic carcinoma. Contrastingly, the CRP/Alb ratio was demonstrated statistical significance in both the entire pancreatic carcinoma cohort (HR = 0.471; p = 0.026) and the PDAC subgroup (HR = 0.484; p = 0.034). CRP/Alb and PF demonstrated a positive association (r=0.489, pConclusionPF concentration is a convenient, rapid, and noninvasive biomarker, and its combination with the CRP/Alb ratio could significantly enhance the accuracy of prognosis prediction in pancreatic carcinoma patients, especially those with the most common histological subtype of PDAC.</p

    Characterization of Organic Phosphorus in Lake Sediments by Sequential Fractionation and Enzymatic Hydrolysis

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    The role of sediment-bound organic phosphorus (P<sub>o</sub>) on lake eutrophication was studied using sequential extraction and enzymatic hydrolysis by collecting sediments from Dianchi Lake, China. Bioavailable P<sub>o</sub> species including labile monoester P, diester P, and phytate-like P were identified in the sequential extractions by H<sub>2</sub>O, NaHCO<sub>3</sub>, and NaOH. For the H<sub>2</sub>O–P<sub>o</sub>, 36.7% (average) was labile monoester P, 14.8% was diester P, and 69.9% was phytate-like P. In NaHCO<sub>3</sub>–P<sub>o</sub>, 19.9% was labile monoester P, 17.5% was diester P, and 58.8% was phytate-like P. For NaOH–P<sub>o</sub>, 25.6% was labile monoester P, 7.9% was diester P, and 35.9% was phytate-like P. Labile monoester P was active to support growth of algae to form blooms. Diester P mainly distributed in labile H<sub>2</sub>O and NaHCO<sub>3</sub> fractions was readily available to cyanobacteria. Phytate-like P represents a major portion of the P<sub>o</sub> in the NaOH fractions, also in the more labile H<sub>2</sub>O and NaHCO<sub>3</sub> fractions. Based on results of sequential extraction of P<sub>o</sub> and enzymatic hydrolysis, lability and bioavailability was in decreasing order as follows: H<sub>2</sub>O–P<sub>o</sub> > NaHCO<sub>3</sub>–P<sub>o</sub> > NaOH–P<sub>o</sub>, and bioavailable P<sub>o</sub> accounted for only 12.1–27.2% of total P<sub>o</sub> in sediments. These results suggest that the biogeochemical cycle of bioavailable P<sub>o</sub> might play an important role in maintaining the eutrophic status of lakes

    Characterization of Organic Phosphorus in Lake Sediments by Sequential Fractionation and Enzymatic Hydrolysis

    No full text
    The role of sediment-bound organic phosphorus (P<sub>o</sub>) on lake eutrophication was studied using sequential extraction and enzymatic hydrolysis by collecting sediments from Dianchi Lake, China. Bioavailable P<sub>o</sub> species including labile monoester P, diester P, and phytate-like P were identified in the sequential extractions by H<sub>2</sub>O, NaHCO<sub>3</sub>, and NaOH. For the H<sub>2</sub>O–P<sub>o</sub>, 36.7% (average) was labile monoester P, 14.8% was diester P, and 69.9% was phytate-like P. In NaHCO<sub>3</sub>–P<sub>o</sub>, 19.9% was labile monoester P, 17.5% was diester P, and 58.8% was phytate-like P. For NaOH–P<sub>o</sub>, 25.6% was labile monoester P, 7.9% was diester P, and 35.9% was phytate-like P. Labile monoester P was active to support growth of algae to form blooms. Diester P mainly distributed in labile H<sub>2</sub>O and NaHCO<sub>3</sub> fractions was readily available to cyanobacteria. Phytate-like P represents a major portion of the P<sub>o</sub> in the NaOH fractions, also in the more labile H<sub>2</sub>O and NaHCO<sub>3</sub> fractions. Based on results of sequential extraction of P<sub>o</sub> and enzymatic hydrolysis, lability and bioavailability was in decreasing order as follows: H<sub>2</sub>O–P<sub>o</sub> > NaHCO<sub>3</sub>–P<sub>o</sub> > NaOH–P<sub>o</sub>, and bioavailable P<sub>o</sub> accounted for only 12.1–27.2% of total P<sub>o</sub> in sediments. These results suggest that the biogeochemical cycle of bioavailable P<sub>o</sub> might play an important role in maintaining the eutrophic status of lakes
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