Auditor of State Mary Mosiman today released a reaudit report on the Mason City Community School District (District) for the period July 1, 2014 through June 30, 2015. The reaudit also covered items applicable to the years ended June 30, 2016 and June 30, 2017.

Auditor of State Mary Mosiman today released a reaudit report on the Mason City Community School District (District) for the period July 1, 2014 through June 30, 2015. The reaudit also covered items applicable to the years ended June 30, 2016 and June 30, 2017

Primer registro de anomalía intersexual gonadal de Trachurus mediterraneus (Steindachner, 1868) desde el Mar de Alborán.

El objetivo principal de este trabajo es dar a conocer el primer registro de una anomalía intersexual gonadal de Trachurus mediterraneus desde el mar de Alborán (Mediterráneo occidental). Este espécimen es el primer registro de intersexualidad para un jurel en el mundo.Postprin

Per-allele OR for rs13387042-A variant and BC risk stratified by hormone receptor status.

a<p>Q statistic test used to assess the heterogeneity in subgroups.</p>b<p>Q statistic test used to assess the heterogeneity between subgroups.</p

Forest plot for association of 2q35-rs13387042 polymorphism and BC risk.

<p>Forest plot for association of 2q35-rs13387042 polymorphism and BC risk.</p

Quantitative Assessment of 2q35-rs13387042 Polymorphism and Hormone Receptor Status with Breast Cancer Risk

<div><p>Background</p><p>The association between rs13387042 polymorphism on 2q35 and breast cancer (BC) has been widely evaluated since it was first identified through genome-wide association approach. However, the results have been inconclusive. To investigate this inconsistency, we performed a meta-analysis of all available studies dealing with the relationship between the 2q35-rs13387042 polymorphism and BC.</p><p>Methods</p><p>Databases including MEDLINE, PubMed, EMBASE, ISI web of science and CNKI (China National Knowledge Infrastructure) were searched to find relevant studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. The random-effects model was applied, addressing heterogeneity and publication bias.</p><p>Results</p><p>A total of 24 articles involving 99,772 cases and 164,985 controls were included. In a combined analysis, the summary per-allele odds ratio (OR) for BC of 2q35-rs13387042 polymorphism was 1.13 (95% CI: 1.11–1.16; P<10⁻⁵). Significant associations were also detected under co-dominant, dominant and recessive genetic models. In the subgroup analysis by ethnicity, significantly increased risks were found in Asians, Caucasians and Hispanic whites for the polymorphism in all comparisons; whereas no significant associations were found among Africans. In addition, we find 2q35-rs13387042 polymorphism conferred significantly risks for both ER-positive and ER-negative tumors. Furthermore, significant associations were also detected both in PR–positive and PR–negative cancer.</p><p>Conclusions</p><p>Our findings demonstrated that rs13387042-A allele is a risk-conferring factors for the development of BC, especially in Asians, Caucasians and Hispanic whites.</p></div

Characteristics of studies included in a meta-analysis of the association between 2q35-rs13387042 and BC.

<p>NA: not applicable.</p

A Genetic Toolbox for Modulating the Expression of Heterologous Genes in the Cyanobacterium <i>Synechocystis</i> sp. PCC 6803

Cyanobacteria, genetic models for photosynthesis research for decades, have recently become attractive hosts for producing renewable fuels and chemicals, owing to their genetic tractability, relatively fast growth, and their ability to utilize sunlight, fix carbon dioxide, and in some cases, fix nitrogen. Despite significant advances, there is still an urgent demand for synthetic biology tools in order to effectively manipulate genetic circuits in cyanobacteria. In this study, we have compared a total of 17 natural and chimeric promoters, focusing on expression of the ethylene-forming enzyme (EFE) in the cyanobacterium <i>Synechocystis</i> sp. PCC 6803. We report the finding that the <i>E. coli</i> σ⁷⁰ promoter Ptrc is superior compared to the previously reported strong promoters, such as PcpcB and PpsbA, for the expression of EFE. In addition, we found that the EFE expression level was very sensitive to the 5′-untranslated region upstream of the open reading frame. A library of ribosome binding sites (RBSs) was rationally designed and was built and systematically characterized. We demonstrate a strategy complementary to the RBS prediction software to facilitate the rational design of an RBS library to optimize the gene expression in cyanobacteria. Our results show that the EFE expression level is dramatically enhanced through these synthetic biology tools and is no longer the rate-limiting step for cyanobacterial ethylene production. These systematically characterized promoters and the RBS design strategy can serve as useful tools to tune gene expression levels and to identify and mitigate metabolic bottlenecks in cyanobacteria

Additional file 1: of Estimated divergence times of Hirsutella (asexual morphs) in Ophiocordyceps provides insight into evolution of phialide structure

Table S1. GenBank accession numbers for sequences used in the phylogenetic analysis of Hirsutella (asexual morph). Table S2. Morphological comparison among Ophiocordyceps retorta and its related species. (DOC 86 kb

Identity percentage of <i>Rubrivivax gelatinosus</i> CBS Hyp1, Hyp2 proteins and the Hyp proteins from <i>Ralstonia eutropha</i> H16, generated by NCBI P-BLAST search.

<p>Identity percentage of <i>Rubrivivax gelatinosus</i> CBS Hyp1, Hyp2 proteins and the Hyp proteins from <i>Ralstonia eutropha</i> H16, generated by NCBI P-BLAST search.</p

Characteristics of Study Participants.

<p>Note:</p>a<p>Proportions were analyzed based on data of the 399 men who completed a questionnaire;</p>b<p>Other ethnicities included Uighur, Kazak, Hui and Manchu;</p>c<p>The currency exchange rate was 7 RMB equaled approximately 1 USD at the time of the study;</p>d<p>P value from Chi-square test;</p>e<p>P value from Fisher's exact test.</p