Oxidative Radical Addition–Cyclization of Sulfonyl Hydrazones with Simple Olefins by Binary Acid Catalysis

An unprecedented binary acid accelerated oxidative radical annulation of sulfonyl hydrazones with simple olefins is described. Notably, this method provides a novel oxidative radical cycloaddition for the construction of six-member heterocycles. It offers a rapid and efficient approach to tetrahydro­pyridazines which are key structural motifs in pharmaceutically active compounds

[4 + 2] Cycloaddition of in Situ Generated 1,2-Diaza-1,3-dienes with Simple Olefins: Facile Approaches to Tetrahydro­pyridazines

A catalyst-free [4 + 2] annulation process between <i>in situ</i> generated 1,2-diaza-1,3-butadienes and simple olefins has been developed. Under mild conditions, the reactions afforded 1,4,5,6-tetrahydro­pyridazines, which feature a wide range of bioactive compounds, with high yields (up to 99% yield)

Asymmetric Binary Acid Catalysis: Switchable Enantioselectivity in Enantioselective Conjugate Hydride Reduction

The exchange of the metal ion from Zr(IV) to Fe(III) leads to a switch in the enantioselectivity of binary acid-catalyzed conjugate hydride reductions. In the presence of Hantzsch ester, γ-indolyl β,γ-unsaturated α-keto esters could be reduced to the desired (S)- or (R)-products, respectively, with good to excellent enantioselectivity (up to 98% ee)

Carbocation Lewis Acid TrBF₄‑Catalyzed 1,2-Hydride Migration: Approaches to (<i>Z</i>)‑α,β-Unsaturated Esters and α‑Branched β‑Ketocarbonyls

Carbocation Lewis acid TrBF4-catalyzed 1,2-hydride migration of α-alkyldiazoacetates themselves or in situ-generated cross-coupling adducts of aldehydes and α-alkyldiazoacetates has been developed, affording (Z)-α,β-unsaturated esters and α-branched β-ketocarbonyls, respectively, in good yields and with high regioselectivities

Construction of Axially Chiral Styrenes Linking an Indole Moiety by Chiral Phosphoric Acid

Herein we report a chiral phosphoric acid-catalyzed intermolecular C2 Friedel–Crafts alkylation reaction between ortho-alkynylnaphthols and various 3-substituted indoles, affording axially chiral alkenes with up to 93% yields (E/Z > 20:1) and up to 98% ee under mild reaction condition. Other substituted indole derivatives could be also tolerated in this system, giving the corresponding axially chiral alkenes with high yields and in excellent enantioselectivity

Carbocation Lewis Acid Catalyzed Diels–Alder Reactions of Anthracene Derivatives

The carbocation salt [Ph₃C]­[BArF] has been identified as a viable Lewis acid catalyst for the Diels–Alder reactions between anthracene derivatives and unsaturated carbonyl compounds with good selectivity and high efficiency

Colocalization analysis results of AAM and ANM.

Colocalization analysis results of AAM and ANM.</p

Genes identified by SMR analysis for ANM.

Genes identified by SMR analysis for ANM.</p