Generalized Multifunctional Coating Strategies Based on Polyphenol-Amine-Inspired Chemistry and Layer-by-Layer Deposition for Blood Contact Catheters

Blood-contacting catheters play a pivotal role in contemporary medical treatments, particularly in the management of cardiovascular diseases. However, these catheters exhibit inappropriate wettability and lack antimicrobial characteristics, which often lead to catheter-related infections and thrombosis. Therefore, there is an urgent need for blood contact catheters with antimicrobial and anticoagulant properties. In this study, we employed tannic acid (TA) and 3-aminopropyltriethoxysilane (APTES) to create a stable hydrophilic coating under mild conditions. Heparin (Hep) and poly­(lysine) (PL) were then modified on the TA-APTES coating surface using the layer-by-layer (LBL) technique to create a superhydrophilic TA/APTES/(LBL)4 coating on silicone rubber (SR) catheters. Leveraging the superhydrophilic nature of this coating, it can be effectively applied to blood-contacting catheters to impart antibacterial, antiprotein adsorption, and anticoagulant properties. Due to Hep’s anticoagulant attributes, the activated partial thromboplastin time and thrombin time tests conducted on SR/TA-APTES/(LBL)4 catheters revealed remarkable extensions of 276 and 103%, respectively, when compared to uncoated commercial SR catheters. Furthermore, the synergistic interaction between PL and TA serves to enhance the resistance of SR/TA-APTES/(LBL)4 catheters against bacterial adherence, reducing it by up to 99.9% compared to uncoated commercial SR catheters. Remarkably, the SR/TA-APTES/(LBL)4 catheter exhibits good biocompatibility with human umbilical vein endothelial cells in culture, positioning it as a promising solution to address the current challenges associated with blood-contact catheters

DataSheet1_Engineered procyanidin-Fe nanoparticle alleviates intestinal inflammation through scavenging ROS and altering gut microbiome in colitis mice.PDF

Inflammatory bowel disease (IBD) is an idiopathic chronic inflammatory bowel disease characterized by inflammation, intestinal barrier injury, and imbalance of gut microbiota. Excess accumulation of reactive oxygen species (ROS) is closely correlated with the development and reoccurrence of IBD. Previous researches demonstrate that procyanidin, as a natural antioxidant, exhibits strong ability of eliminating ROS, thus showing good therapeutic effects in the inflammation-related diseases. Non-etheless, its poor stability and solubility always limits the therapeutic outcomes. Here, we typically designed an antioxidant coordination polymer nanoparticle using the engineering of procyanidin (Pc) and free iron (Fe), named Pc-Fe nanozyme, for effectively scavenging ROS and further inhibiting inflammation while altering the gut microbiome for the treatment of colitis. Furthermore, in vitro experiments uncover that Pc-Fe nanoparticles exert strong multi biomimic activities, including peroxidase, and glutathione peroxidase, for the scavenging of ROS and protecting cells from oxidative injury. In addition, the colon accumulation of Pc-Fe nanozyme effectively protects the intestinal mucosa from oxidative damage while significantly downregulates pro-inflammatory factors, repairs the intestinal barriers and alternates gut microbiome after orally administrated in sodium dextran sulfate (DSS) induced colitis mice. The results collectively illustrate that the multienzyme mimicking Pc-Fe nanozyme owns high potential for treating IBD through scavenging ROS, inhibiting inflammation, repairing gut barriers and alternating gut microbiome, which further promising its clinical translation on IBD treatment and other ROS induced intestinal diseases.</p

Photoreversible Bond-Based Shape Memory Polyurethanes with Light-Induced Self-Healing, Recyclability, and 3D Fluorescence Encryption

Developing a shape memory polyurethane with high mechanical properties, excellent self-healing has become a huge challenge for the development of smart materials. Herein, we report the design and fabrication of a shape memory polyurethane network terminated with coumarin units (HEOMC-PU) to address this conundrum. The synthesized HEOMC-PU exhibits exceptional mechanical performance with a breaking elongation of 746% and toughness of 55.5 MJ·m–3. By utilizing the dynamically reversible behavior of coumarin units to repair the damaged network, the efficient self-healing performance (99.2%) of HEOMC-PU is obtained. In addition, the prepared network and light-induced dynamic reversibility endow the HEOMC-PU with both liquid-state remoldability and solid-state plasticity, respectively, enabling polyurethane to be recycled and processed multiple times. Furthermore, based on the fluorescence responsive characteristic of coumarin, HEOMC-PU with a fluorescent pattern can be deformed into specific three-dimensional configurations by combining photolithography, self-healing, and the shape memory effect. Such a multilevel and multidimensional anti-counterfeiting platform with rewritable fluorescent patterns and reconfigurable shapes can open up a new encryption approach for future intelligent anti-counterfeiting

Photoreversible Bond-Based Shape Memory Polyurethanes with Light-Induced Self-Healing, Recyclability, and 3D Fluorescence Encryption

Developing a shape memory polyurethane with high mechanical properties, excellent self-healing has become a huge challenge for the development of smart materials. Herein, we report the design and fabrication of a shape memory polyurethane network terminated with coumarin units (HEOMC-PU) to address this conundrum. The synthesized HEOMC-PU exhibits exceptional mechanical performance with a breaking elongation of 746% and toughness of 55.5 MJ·m–3. By utilizing the dynamically reversible behavior of coumarin units to repair the damaged network, the efficient self-healing performance (99.2%) of HEOMC-PU is obtained. In addition, the prepared network and light-induced dynamic reversibility endow the HEOMC-PU with both liquid-state remoldability and solid-state plasticity, respectively, enabling polyurethane to be recycled and processed multiple times. Furthermore, based on the fluorescence responsive characteristic of coumarin, HEOMC-PU with a fluorescent pattern can be deformed into specific three-dimensional configurations by combining photolithography, self-healing, and the shape memory effect. Such a multilevel and multidimensional anti-counterfeiting platform with rewritable fluorescent patterns and reconfigurable shapes can open up a new encryption approach for future intelligent anti-counterfeiting

Correction to “Photoreversible Bond-Based Shape Memory Polyurethanes with Light-Induced Self-Healing, Recyclability, and 3D Fluorescence Encryption”

Correction to “Photoreversible Bond-Based Shape Memory Polyurethanes with Light-Induced Self-Healing, Recyclability, and 3D Fluorescence Encryption

Highly Fluorinated Al-Centered Lithium Salt Boosting the Interfacial Compatibility of Li-Metal Batteries

Formulating electrolytes is very powerful in protecting lithium (Li) anode from severe Li dendrites growth and pulverization. Herein, by a simple one-step and one-pot method, we innovatively synthesize a highly fluorinated (8-CF3) aluminum (Al)-centered lithium salt of lithium perfluoropinacolato­aluminate (LiFPA). The as-formulated LiFPA-based electrolytes enable practical Li/LiCoO2 (areal capacity 1.98 mAh cm–2) and Li/LiNi0.6Co0.2Mn0.2O2 (areal capacity 3.5 mAh cm–2) Li metal batteries (LMBs) with good cycling stability. On the one hand, LiFPA salt can reduce electrolyte surface tension, improve electrolyte wettability, and ultimately suppress Li dendrites growth. On the other hand, the LiFPA salt will facilitate the formation of a protective passivating interphase layer on both electrodes. Our work states the importance of synthesizing of lithium salts with good interfacial compatibility for high performance LMBs

Rapid Self-Healing and High-Mechanical-Strength Epoxy Resin Coatings Incorporating Dynamic Disulfide Bonds

Smart materials with outstanding self-healing and reprocessable capabilities are highly desirable for next-generation coatings that can repair damaged coatings in a timely and autonomous manner. However, their prevalent use in practical applications is currently hindered by various limitations, such as low mechanical strength, long healing time, and expensive raw materials. Herein, we prepared a reprocessable epoxy resin coating (EP-SS-DAAX) with excellent self-healing and mechanical properties by incorporating dynamic disulfide bonds and flexible long chains into the resin network. The presence of flexible long chains promoted the mobility of molecular chains and the dynamic exchange of disulfide bonds, resulting in efficient self-healing and high toughness of the coating. EP-SS-DAA2 obtained a tensile strength of 33.30 MPa and a breaking elongation of 150.55% after 1 h of self-healing on the basis of achieving a high self-healing efficiency (93.68%) and can be reprocessed through hot-pressing with a tensile strength recovery rate of 107.03%. As a proof of concept, the healed coatings demonstrated excellent anticorrosive effects after being immersed in a 3.5 wt % NaCl aqueous solution for 7 days. This study provides a feasible approach to obtaining high-performance and reprocessable epoxy resins that have extraordinary integrated self-healing properties and mechanical performance

Rapid Self-Healing and High-Mechanical-Strength Epoxy Resin Coatings Incorporating Dynamic Disulfide Bonds

Smart materials with outstanding self-healing and reprocessable capabilities are highly desirable for next-generation coatings that can repair damaged coatings in a timely and autonomous manner. However, their prevalent use in practical applications is currently hindered by various limitations, such as low mechanical strength, long healing time, and expensive raw materials. Herein, we prepared a reprocessable epoxy resin coating (EP-SS-DAAX) with excellent self-healing and mechanical properties by incorporating dynamic disulfide bonds and flexible long chains into the resin network. The presence of flexible long chains promoted the mobility of molecular chains and the dynamic exchange of disulfide bonds, resulting in efficient self-healing and high toughness of the coating. EP-SS-DAA2 obtained a tensile strength of 33.30 MPa and a breaking elongation of 150.55% after 1 h of self-healing on the basis of achieving a high self-healing efficiency (93.68%) and can be reprocessed through hot-pressing with a tensile strength recovery rate of 107.03%. As a proof of concept, the healed coatings demonstrated excellent anticorrosive effects after being immersed in a 3.5 wt % NaCl aqueous solution for 7 days. This study provides a feasible approach to obtaining high-performance and reprocessable epoxy resins that have extraordinary integrated self-healing properties and mechanical performance

Rapid Self-Healing and High-Mechanical-Strength Epoxy Resin Coatings Incorporating Dynamic Disulfide Bonds

Smart materials with outstanding self-healing and reprocessable capabilities are highly desirable for next-generation coatings that can repair damaged coatings in a timely and autonomous manner. However, their prevalent use in practical applications is currently hindered by various limitations, such as low mechanical strength, long healing time, and expensive raw materials. Herein, we prepared a reprocessable epoxy resin coating (EP-SS-DAAX) with excellent self-healing and mechanical properties by incorporating dynamic disulfide bonds and flexible long chains into the resin network. The presence of flexible long chains promoted the mobility of molecular chains and the dynamic exchange of disulfide bonds, resulting in efficient self-healing and high toughness of the coating. EP-SS-DAA2 obtained a tensile strength of 33.30 MPa and a breaking elongation of 150.55% after 1 h of self-healing on the basis of achieving a high self-healing efficiency (93.68%) and can be reprocessed through hot-pressing with a tensile strength recovery rate of 107.03%. As a proof of concept, the healed coatings demonstrated excellent anticorrosive effects after being immersed in a 3.5 wt % NaCl aqueous solution for 7 days. This study provides a feasible approach to obtaining high-performance and reprocessable epoxy resins that have extraordinary integrated self-healing properties and mechanical performance