DNA methylation heatmap constructed using unsupervised hierarchical Ward clustering of the 711 CpG sites with the greatest variance across the 68 tumor samples identified six distinct methylation clusters.

<p>DNA methylation heatmap constructed using unsupervised hierarchical Ward clustering of the 711 CpG sites with the greatest variance across the 68 tumor samples identified six distinct methylation clusters.</p

Kaplan-Meier survival curves depicting three year survival for each of the six clusters identified via unsupervised hierarchical cluster analysis.

<p>Kaplan-Meier survival curves depicting three year survival for each of the six clusters identified via unsupervised hierarchical cluster analysis.</p

Candidate enriched gene sets for differentially methylated genes associated with HPV status.

<p>Candidate enriched gene sets for differentially methylated genes associated with HPV status.</p

CpG sites with DNA methylation values significantly associated (Adjusted p<0.05) with HPV status of the tumor.

<p>Positive T-Values correspond with higher methylation in HPV(+) while negative T-Values correspond with higher methylation in HPV(−) tumors.</p

Clinical characteristics of the study participants (n = 68).

<p>Clinical characteristics of the study participants (n = 68).</p

Clinical characteristics of the six clusters identified via unsupervised hierarchical cluster analysis of DNA methylation values.

*<p>p<0.05 for difference between clusters.</p>a<p>Problem drinking defined: AUDIT>8 and drank in past 1 year. Note: n = 14 missing AUDIT score.</p