From little things, big things grow

Claire Jennings and Karen Stagnitti report on an early intervention project that provides the opportunity for children from vulnerable families in country Victoria to learn the essential skills of listening, concentration and curiosity.<br /

PrkA controls peptidoglycan biosynthesisthrough the essential phosphorylation ofReoM

Peptidoglycan (PG) is the main component of bacterial cell walls and the target formany antibiotics. PG biosynthesis is tightly coordinated with cell wall growth and turnover, andmany of these control activities depend upon PASTA-domain containing eukaryotic-like serine/threonine protein kinases (PASTA-eSTK) that sense PG fragments. However, only a few PGbiosynthetic enzymes are direct kinase substrates. Here, we identify the conserved ReoM proteinas a novel PASTA-eSTK substrate in the Gram-positive pathogenListeria monocytogenes. Our datashow that the phosphorylation of ReoM is essential as it controls ClpCP-dependent proteolyticdegradation of the essential enzyme MurA, which catalyses the first committed step in PGbiosynthesis. We also identify ReoY as a second novel factor required for degradation of ClpCPsubstrates. Collectively, our data imply that the first committed step of PG biosynthesis is activatedthrough control of ClpCP protease activity in response to signals of PG homeostasis imbalance.Peer Reviewe

Wind Speed Influences on Marine Aerosol Optical Depth

The Mulcahy (Mulcahy et al., 2008) power-law parameterization, derived at the coastal Atlantic station Mace Head, between clean marine aerosol optical depth (AOD) and wind speed is compared to open ocean MODIS-derived AOD versus wind speed. The reported AOD versus wind speed (U) was a function of ∼U2. The open ocean MODIS-derived AOD at 550 nm and 860 nm wavelengths, while in good agreement with the general magnitude of the Mulcahy parameterization, follows a power-law with the exponent ranging from 0.72 to 2.47 for a wind speed range of 2–18 m s−1. For the four cases examined, some MODIS cases underestimated AOD while other cases overestimated AOD relative to the Mulcahy scheme. Overall, the results from MODIS support the general power-law relationship of Mulcahy, although some linear cases were also encountered in the MODIS dataset. Deviations also arise between MODIS and Mulcahy at higher wind speeds (>15 m s−1), where MODIS-derived AOD returns lower values as compared to Mulcahy. The results also support the suggestion than wind generated sea spray, under moderately high winds, can rival anthropogenic pollution plumes advecting out into marine environments with wind driven AOD contributing to AOD values approaching 0.3

The structure of protostellar envelopes derived from submillimeter continuum images

High dynamic range imaging of submillimeter dust emission from the envelopes of eight young protostars in the Taurus and Perseus star-forming regions has been carried out using the SCUBA submillimeter camera on the James Clerk Maxwell Telescope. Good correspondence between the spectral classifications of the protostars and the spatial distributions of their dust emission is observed, in the sense that those with cooler spectral energy distributions also have a larger fraction of the submillimeter flux originating in an extended envelope compared with a disk. This results from the cool sources having more massive envelopes rather than warm sources having larger disks. Azimuthally-averaged radial profiles of the dust emission are used to derive the power-law index of the envelope density distributions, p (defined by rho proportional to r^-p), and most of the sources are found to have values of p consistent with those predicted by models of cloud collapse. However, the youngest protostars in our sample, L1527 and HH211-mm, deviate significantly from the theoretical predictions, exhibiting values of p somewhat lower than can be accounted for by existing models. For L1527 heating of the envelope by shocks where the outflow impinges on the surrounding medium may explain our result. For HH211-mm another explanation is needed, and one possibility is that a shallow density profile is being maintained in the outer envelope by magnetic fields and/or turbulence. If this is the case star formation must be determined by the rate at which the support is lost from the cloud, rather than the hydrodynamical properties of the envelope, such as the sound speed.Comment: Accepted for publication in the Astrophysical Journa

Higher habitual intakes of flavonoids and flavonoid-rich foods are associated with a lower incidence of type 2 diabetes in the UK Biobank cohort

Aim: To examine the associations of a diet high in flavonoid-rich foods, as reflected by a “Flavodiet Score” (FDS), the major individual food contributors to flavonoid intake, and flavonoid subclasses with type 2 diabetes (T2D) risk in the UK Biobank cohort. Materials and methods: Flavonoid intakes were estimated from ≥2 dietary assessments among 113,097 study participants [age at enrolment: 56 ± 8 years; 57% female] using the U.S Department of Agriculture (USDA) databases. Multivariable Cox proportional hazards models were used to investigate associations between dietary exposures and T2D. Results: During 12 years of follow-up, 2628 incident cases of T2D were identified. A higher FDS (compared to lower [Q4 vs. Q1]), characterised by an average of 6 servings of flavonoid-rich foods per day, was associated with a 26% lower T2D risk [HR: 0.74 (95% CI: 0.66–0.84), ptrend = \u3c0.001]. Mediation analyses showed that lower body fatness and basal inflammation, as well as better kidney and liver function partially explain this association. In food-based analyses, higher intakes of black or green tea, berries, and apples were significantly associated with 21%, 15%, and 12% lower T2D risk. Among individual flavonoid subclasses, 19–28% lower risks of T2D were observed among those with the highest, compared to lowest intakes. Conclusions: A higher consumption of flavonoid-rich foods was associated with lower T2D risk, potentially mediated by benefits to obesity/sugar metabolism, inflammation, kidney and liver function. Achievable increases in intakes of specific flavonoid-rich foods have the potential to reduce T2D risk

Mechanisms of action and outcomes for students in Recovery Colleges

Objective\ud Recovery Colleges are widespread, with little empirical research on how they work and outcomes they produce. This study aimed to co-produce a change model characterising mechanisms of action and outcomes for mental health service users attending as students at a Recovery College.\ud Methods\ud A systematised review identified all Recovery College publications. Inductive collaborative data analysis by academic researchers and co-researchers with lived experience of ten key papers informed a theoretical framework for mechanisms and outcome for students, which was refined through deductive analysis of 34 further publications. A change model was co-produced and then refined through stakeholder interviews (n=33).\ud Results\ud Three mechanisms of action for Recovery College students were identified: empowering environment (safety, respect, supporting choices), enabling different relationships (power, peers, working together) and facilitating personal growth (e.g. co-produced learning, strengths, celebrating success). Outcomes were change in the student (e.g. self-understanding, self-confidence) and changes in the student’s life (e.g. occupational, social, service use). A co-produced change model mapping mechanisms of action to outcomes was created.\ud Conclusions\ud The key features identified as differentiating Recovery Colleges from traditional services are an empowering environment, enabling relationships and growth orientation. Recovery Colleges may benefit most attenders, but mental health service users to particularly encourage to enrol may include those who lack confidence, those who services struggle to engage with, those who will benefit from exposure to peer role models, and those lacking social capital. The change model provides the first testable characterisation of mechanisms and outcomes, allowing formal evaluation of Recovery Colleges

Metallothionein-I/II expression associates with the astrocyte DNA damage response and not Alzheimer-type pathology in the ageing brain

Oxidative stress and oxidative DNA damage are early features of mild cognitive impairment and Alzheimer’s disease (AD), occurring before the formation of classical AD neuropathology, and resulting from an imbalance between pro- and anti-oxidants. Astrocytes play a major neuroprotective role, producing high levels of anti-oxidants including metallothionein-I and –II (MT-I/II). In the present study we characterized the immunoreactive profile of MT-I/II in the temporal cortex of the Cognitive Function and Ageing Study (CFAS) aging population-representative neuropathology cohort, and examined H2O2-modulation of MT transcription by human astrocytes. MT-I/II is primarily expressed by astrocytes in the aging brain, but is also associated with pyramidal neurons in a small proportion of cases. Astrocyte expression of MT-I/II does not correlate with Alzheimer-type pathology (Aβ plaques and neurofibrillary tangles) but does relate to astrocyte oxidative DNA damage (rs= 0.312, p= 0.006) and the astrocyte response to oxidative DNA damage in vivo (rs= 0.238, p= 0.04), and MT gene expression is significantly induced in human astrocytes response to oxidative stress in vitro (p=0.01). In contrast, neuronal MT-I/II does not relate to oxidative DNA damage or the neuronal DNA damage response, but is significantly higher in cases with high levels of local tangle pathology (p=0.007). As MT-I/II is neuroprotective against oxidative stress, modulation of MT-I/II expression is a potential therapeutic target to treat the onset and progression of cognitive impairment

Rapid Climate Risk Assessment for the Southern Africa Development Community (SADC) Region

This rapid climate risk assessment for the Southern Africa Development Community (SADC) uses the Intergovernmental Panel on Climate Change (IPCC) 2014 risk analysis framework to assess the distribution of climate hazards and social and biophysical vulnerability to those hazards in order to identify climate risk hotspots. The assessment uses regional climate models from CORDEX-Africa to map rainfall extremes and drought hazards to 2031–2059. Ten social and biophysical vulnerability indicators are identified from across the capital assets (human, physical, social, financial, natural), using data from the Global Multidimensional Poverty Index (MPI), to develop a vulnerability index. The vulnerability index and distribution of climate hazards are mapped to identify hotspots. Hotspots of vulnerability to and risk of extreme rainfall are shown in northern Madagascar and in south west Tanzania, under both the RCP4.5 and 8.5 scenarios. These hotspots also correspond to the hotspots for drought risk under RCP4.5 and 8.5. However, it is clear that medium-high climate risk (high vulnerability, medium-high climate hazard) is widespread across Angola, Democratic Republic of the Congo (DRC), Tanzania, Mozambique, and Madagascar

Diamond Line - Fall 2020

In following up the premier issue of The Diamond Line, the fall 2020 editorial staff had big shoes to fill. We took on the challenge of creating something that would uphold the framework of Issue 1 while simultaneously branching out from its margins. Like the editors before us, we had a vision, but ours took a new form — bright, warm colors. Sunset colors. Moons. Playful lines. Isolation and introspection. A stroll through an art gallery. A coming-of-age story bound between two groovy orange bookends. While Issue 2 does not have an overarching theme, we chose the cover art, “Pandemic Prom” by Autumn Blaylock, because it beautifully encompassed the pages within and the vision we were working toward

Diamond Line - Fall 2020

In following up the premier issue of The Diamond Line, the fall 2020 editorial staff had big shoes to fill. We took on the challenge of creating something that would uphold the framework of Issue 1 while simultaneously branching out from its margins. Like the editors before us, we had a vision, but ours took a new form — bright, warm colors. Sunset colors. Moons. Playful lines. Isolation and introspection. A stroll through an art gallery. A coming-of-age story bound between two groovy orange bookends. While Issue 2 does not have an overarching theme, we chose the cover art, “Pandemic Prom” by Autumn Blaylock, because it beautifully encompassed the pages within and the vision we were working toward