Left ventricular flow from apex to base during systole and isovolumic relaxation in a patient with hypertrophic cardiomyopathy and midventricular obstruction

The occurrence of a left ventricular anterograde flow velocity (maximal: 3·9m . s−1) is demonstrated in a 32-year-old patient with hypertrophic cardioinyopathy and midveniricular obstruction, beginning at early systole and persisting throughout the isovolumic relaxation. Cardiac catheterization with simultaneous dual high fidelity pressure measurements in the apical and basal chambers confirmed the presence of the Doppler maximal instantaneous pressure gradient of 60 mmHg. Contrast left ventricular angiography excluded apical dyskinesia. In the two intracavity compartments, isovolumic relaxation time and the time constant of pressure decay (τ) were abnormal whereby τ was more delayed in the apical than in the basal portion. The presence of an apical high pressure zone during systole with impeded and delayed emptying through the midventricular obstacle and the late onset and prolongation of relaxation are thought to be the cause of the intraventricular flow from apex to base lasting from early systole throughout isovolumic relaxatio

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Feasibility of integrated bivalve farming at Pallipuram in Vypeen Island, Cochin

The technologies for edible oyster and mussel farming have been developed by CMFRI in 1980's. In order to facilitate the transfer of technologies, several demonstration trials have been carried out at various locations to test the adaptability, ecofriendliness, economic viability and sustainability of these technologies

Metacyclic Trypanosoma vivax possess a surface coat

Coated metacyclics of Trypanosoma vivax exist in the hypopharynges of infected tsetse flies and are extruded in low numbers when the flies are induced to probe onto warm slides or into medium. After extensive searching of T. vivax-infected proboscides, and resort to a process for the examination of single, extruded, metacyclic trypanosomes, electron micro scopic evidence is presented that, contrary to an earlier report, metacyclic T. vivaxacquire a surface coat before contact with the mammalian host. Since T. vivax exhibits antigenic variation, the role of the surface coat in this species is likely to be functionally equivalent to the surface coat of the other tsetse-transmitted trypanosome species, T. brucei and T. congolens

Agricultural land use and human presence around breeding sites increase stress-hormone levels and decrease body mass in barn owl nestlings.

Human activities can have a suite of positive and negative effects on animals and thus can affect various life history parameters. Human presence and agricultural practice can be perceived as stressors to which animals react with the secretion of glucocorticoids. The acute short-term secretion of glucocorticoids is considered beneficial and helps an animal to redirect energy and behaviour to cope with a critical situation. However, a long-term increase of glucocorticoids can impair e.g. growth and immune functions. We investigated how nestling barn owls (Tyto alba) are affected by the surrounding landscape and by human activities around their nest sites. We studied these effects on two response levels: (a) the physiological level of the hypothalamus-pituitary-adrenal axis, represented by baseline concentrations of corticosterone and the concentration attained by a standardized stressor; (b) fitness parameters: growth of the nestlings and breeding performance. Nestlings growing up in intensively cultivated areas showed increased baseline corticosterone levels late in the season and had an increased corticosterone release after a stressful event, while their body mass was decreased. Nestlings experiencing frequent anthropogenic disturbance had elevated baseline corticosterone levels, an increased corticosterone stress response and a lower body mass. Finally, breeding performance was better in structurally more diverse landscapes. In conclusion, anthropogenic disturbance affects offspring quality rather than quantity, whereas agricultural practices affect both life history traits

The Influence of Internal Communication Against the Effectiveness of the Service in the Office of the Head of Mandolang Regency of Minahasa in North Sulawesi Province

The purpose of this research is to know the extent of the influence of communication internalagainst the effectiveness of the sevices in the Office of the head of Mandolang District Minahasa in NorthSulawesi Province. This research using quantitative research methods. With the samples used is SaturatedSampling are 35 people. Based on a simple linier regression analysis showed that there is influence ofinternal communication between (X) and (Y) work efficiency. It is evident simple linier regression equationof Y=14,613 + 0,538 X + e. for calculation of the correlation relationship is category of being, This evidencedby the r value 0,565 interpretation advanced by Sugiono are in the interval (0,00-0,199). And the value ofthe coefficient of determination is 31,9% indicating that the influence of internal commucation against theeffectiveness of the service namely 31,9% and the rest is 68,1% influenced by variables that are not includedin this research.From the results of the comparism of the value of a sig (0,03) a (0,05) these authors conclude thatinternal influential communication significantly to the effectiveness of the sevices Head Office Mandolangin the Regency of Minahasa in North Sulawesi province. Then the hypothesis in this study was acceptedH1and H0 denied

Experimental Facilities at the High Energy Frontier

The main theme of the lectures covered the experimental work at hadron colliders, with a clear focus on the Large Hadron Collider (LHC) and on the roadmap that led finally to the discovery of the Higgs boson. The lectures were not a systematic course on machine and detector technologies, but rather tried to give a physics-motivated overview of many experimental aspects that were all relevant for making the discovery. The actual lectures covered a much broader scope than what is documented here in this writeup. The successful concepts for the experiments at the LHC have benefitted from the experience gained with previous generations of detectors at lower-energy machines. The lectures included also an outlook to the future experimental programme at the LHC, with its machine and experiments upgrades, as well as a short discussion of possible facilities at the high energy frontier beyond LHC.Comment: 32 pages, contribution to the CERN in the Proceedings of the 2015 CERN-Latin-American School of High-Energy Physics, Ibarra, Ecuador, 4 - 17 March 201

Dynamics of aortic flow in hypertrophic cardiomyopathy

The purpose of this study was to reassess left ventricular ejection dynamics in hypertrophic cardiomyopathy, to investigate whether a premature stoppage of ejection occurs, as previously reported, and whether reliable criteria for left ventricular outflow tract obstruction can be established by non-invasive evaluation of aortic flow patterns. In a group of 21 patients with hypertrophic cardiomyopathy, composed of 9 with the obstructive form (HOCM), 9 with the non-obstructive form (HNCM) and 3 with apical hypertrophy (HACM), instantaneous flow velocities across the ascending aorta were determined non-invasively with a 16-gated Doppler 2-D echo instrument. Ten normals served as controls. The 16 flow velocities were averaged over 8 heart beats and the relative volume flow rate was calculated by microprocessor analysis. Ejection time (i.e. flow time) derived from the flow curves was compared with the available ejection period as determined from the carotid pulse tracing. In normals, ejection time amounted to 94±3% of the available ejection period, in HOCM to 92±5% and in HNCM to 93±4% (no significant differences). In HACM, however, ejection time was reduced to 71±14% of the available ejection period. In contrast to HNCM, aortic flow in HOCM was characterized by an early peak followed by a plateau at a sizeably lower flow level for the rest of systole. Flow time of an abnormally short duration was the hallmark of HACM. We conclude that in patients with hypertrophic cardiomyopathy, HOCM and HNCM can be distinguished by the shape of their volume flow curves. A premature stoppage of ejection is only found in patients with HAC