Additional file 2: of Parkinson’s disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in astrocytes

Figure S1. The LRRK2-GS mutant induces ER stress and apoptosis in tunicamycin-treated astrocytes. Figure S2. LRRK2-GS is localized to the ER membrane. Figure S3. Analysis of GS-LRRK2–interacting proteins. Figure S4. Identification of GS-LRRK2–interacting proteins. Figure S5. LRRK2-GS promotes SERCA–PLN complex formation. Figure S6. LRRK2 kinase activity does not affect LRRK2 localization. Figure S7. LRRK2-GS astrocytes affect neuronal survival. Table S2. List of siRNA oligonucleotides. Table S3. List of primers used for qPCR. Table S4. List of primary antibodies used in this work. (PDF 5703 kb

Additional file 1: of Parkinson’s disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in astrocytes

Table S1. List of LRRK2 interacting proteins, Related Figure 3. (XLSX 41 kb

Demographic and genotypic characteristics of subjects from the Alpha-1 Foundation DNA and Tissue Bank and the Lung Health Study.

<p>*Mean ± standard error of the mean.</p

Log₁₀ of telomere length in the lung vs. log₁₀ of telomere length in the blood.

<p>Log₁₀ of telomere length in the lung vs. log₁₀ of telomere length in the blood.</p

Log₁₀ of telomere length in α₁-antitrypsin deficient COPD patients vs. log₁₀ of telomere length in COPD controls.

<p>Log₁₀ of telomere length in α₁-antitrypsin deficient COPD patients vs. log₁₀ of telomere length in COPD controls.</p

Mean log₁₀ of telomere length in the blood and lung tissue.

<p>Mean log₁₀ of telomere length in the blood and lung tissue.</p

MOESM1 of Accumulation of genetic variants associated with immunity in the selective breeding of broilers

Additional file 1: Table S1. Breeds and Naming Convention for the 15 Samples Analyzed in this Study. The main text uses the abbreviation to refer to each breed. Genomes sequenced from pooled blood samples are specified in brackets in the “Name” column

Kaplan-Meier survival curves for cancer mortality by leukocyte telomere length of 4271 subjects in the LHS.

<p>Subjects are divided into quartiles 1, 2, and 3 (shorter telomeres) versus quartile 4 (longest telomeres). P value was derived from multivariable Cox models. HR between Q1–3 and Q4 is 1.48 (95% CI, 1.04–2.11).</p

Kaplan-Meier survival curves for all-cause mortality by leukocyte telomere length of 4271 subjects in the LHS.

<p>Subjects are divided into quartiles 1, 2, and 3 (shorter telomeres) versus quartile 4 (longest telomeres). P value was derived from multivariable Cox models. Hazard ratio between Q1–3 and Q4 is 1.48 (95% CI, 1.02–1.66).</p

Telomere length in smoker groups in LHS and mid-life controls.

<p>Mid-life controls (n = 53; mean age = 45.34), sustained quitters (n = 753; mean age = 54.07), intermittent quitters (n = 1,192; mean age = 53.26), continuous smokers (n = 2,319), COPD (ABC) controls (n = 20; mean age = 64.80). Results are expressed as mean ± standard error. *p<0.001 vs. mid-life control group.</p