Countries that published more than 15 GPRD studies between 1995 and 2009 ranked by the number of GPRD studies per million inhabitants.

<p>Values in parentheses are rankings. SCI, Scientific Citation Index.</p

Cumulated numbers and average annual growth rates of GPRD studies published between 1995 and 2009.

<p>Cumulated numbers and average annual growth rates of GPRD studies published between 1995 and 2009.</p

Top 10 fields of study ranked by number of GPRD studies published between 1995 and 2009.

<p>Top 10 fields of study ranked by number of GPRD studies published between 1995 and 2009.</p

Top 10 journals ranked by number of GPRD studies published between 1995 and 2009.

<p>Top 10 journals ranked by number of GPRD studies published between 1995 and 2009.</p

Citation counts of GPRD studies published between 1995 and 2009.

a<p>Citation counts were calculated as numbers of articles that citing GPRD studies.</p

Cumulative numbers of GPRD studies compared with epidemiologic studies using public electronic health database in Canada, France and Germany.

<p>The cumulative numbers of studies published between 1995 and 2009 (solid data points) were fitted well with a power growth model (solid line). The predicted cumulative numbers of GPRD studies were then extrapolated by the fitted power model (hollow data points with short dashed line). The extrapolation should be interpreted cautiously under assumption. Data source: Germany: studies using German health insurance medication claims data <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0021404#pone.0021404-Hoffmann1" target="_blank">[8]</a>; France: studies using French reimbursement databases <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0021404#pone.0021404-MartinLatry1" target="_blank">[9]</a>; Canada: studies using Manitoba and Saskatchewan administrative health care utilization databases <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0021404#pone.0021404-Tricco1" target="_blank">[10]</a>.</p

National share of internationally co-authored SCI studies and GPRD studies by countries.

<p>National share of internationally co-authored publications was calculated by the number of internationally co-authored work divided by the number of GPRD studies or SCI studies of the given country. As comparison reference values, the national share of internationally co-authored nationwide publications published in 2009 and indexed in the Scientific Citation Index Expand of given countries are plotted and abbreviated as SCI studies (Accessed 12 May 2010.).</p

Number of authors and GPRD studies with their cumulative percentage as grouped by number of authored GPRD studies published between 1995 and 2009.

<p>Number of authors and GPRD studies with their cumulative percentage as grouped by number of authored GPRD studies published between 1995 and 2009.</p

Cumulative incidence of stroke.

<p>The vertebroplasty group had similar cumulative incidences of (<b>A</b>) any stroke, (<b>B</b>) hemorrhagic stroke, and (<b>C</b>) ischemic stroke as the comparison group from the immediate post-operative period till the end of the five-year follow-up.</p

Flow of data processing.

<p>From an osteoporotic cohort of 58,703 patients in a nationwide representative cohort of one million people, 421 patients had percutaneous vertebroplasty (vertebroplasty group; n = 421), while age-, sex- and propensity score-matched patients comprised the comparison group (n = 1,655). The two groups were compared and followed-up for up to five years for subsequent stroke events.</p