Stereoselective Synthesis of β-Mannopyranosides via the Temporary Silicon Connection Method

Stereoselective Synthesis of β-Mannopyranosides via the Temporary Silicon Connection Metho

Stereoselective Synthesis of β-Mannopyranosides via the Temporary Silicon Connection Method

Stereoselective Synthesis of β-Mannopyranosides via the Temporary Silicon Connection Metho

A Colorimetric Ligand for Mercuric Ion

Practical materials are needed to expedite the detection and screening of heavy metals. This Letter describes the synthesis of a new phosphorodithioate-based ligand 1 that specifically communicates a color change when exposed to mercuric ion. The origin of this recognition arises through a charge transfer and solubility change. This ligand now extends a new means to visually screen and spectroscopically quantify mercuric ion

Identification of the Binding of Sceptrin to MreB via a Bidirectional Affinity Protocol

Identification of the Binding of Sceptrin to MreB via a Bidirectional Affinity Protoco

Identification of the Binding of Sceptrin to MreB via a Bidirectional Affinity Protocol

Identification of the Binding of Sceptrin to MreB via a Bidirectional Affinity Protoco

Synthesis and Evaluation of a Fluorescent Ritterazine–Cephalostatin Hybrid

The cephalostatin and ritterazine natural products comprise a potent family of bis-steroidal pyrazines that display potent single-digit nanomolar inhibition of tumor cell growth. An active fluorescent ritterazine–cephalostatin hybrid probe was developed using detailed SAR data derived through total synthetic efforts. A combination of time course and confocal imaging studies indicate that this natural product family is rapidly taken up in tumor cells and localizes subcellularly within ER and surrounding the nuclear–ER interface

Modular Synthesis of Pantetheine and Phosphopantetheine

d-Pantetheine and d-phosphopantetheine, precursors to coenzyme A, have been synthesized though a linear sequence from three modules (M1−M3) in 9 and 10 steps, respectively. These routes provide access to analogues of coenzyme A containing modified cystamines, β-alanines, and pantoic acid residues. All three modules were joined using conventional methods of peptide synthesis. The chiral component, M3, was derived from d-pantolactone

Ganodone, a Bioactive Benzofuran from the Fruiting Bodies of <i>Ganoderma tsugae</i>

Extracts of <i>Ganoderma tsugae</i>, also known as the Hemlock varnish shelf mushroom, and related Reishi mushrooms are well documented in traditional Chinese medicine. Several <i>Ganoderma</i> sp. are currently cultivated for use in coffee, teas, and dietary supplements. We now report on the isolation and characterization of an unprecedented benzofuran, ganodone (<b>1</b>), from the fruiting bodies of mature growth <i>G. tsugae</i>. This discovery provides a key next step in evaluating the active components in their associated herbal supplements

A Three-Component Photoreversible Tag for Thiols

A one-pot coupling of a 1,3-diketone, an aldehyde, and an alkanethiol has been developed to produce a protected sulfide. Through use of an o-nitrophenylbenzaldehyde, this method provides a one-step route to a photochemically reversible thiol-protecting group. The kinetics of photolysis were established using 1H NMR analysis, which allows for the rate to be based on the entire reaction scheme

Ganodone, a Bioactive Benzofuran from the Fruiting Bodies of <i>Ganoderma tsugae</i>

Extracts of <i>Ganoderma tsugae</i>, also known as the Hemlock varnish shelf mushroom, and related Reishi mushrooms are well documented in traditional Chinese medicine. Several <i>Ganoderma</i> sp. are currently cultivated for use in coffee, teas, and dietary supplements. We now report on the isolation and characterization of an unprecedented benzofuran, ganodone (<b>1</b>), from the fruiting bodies of mature growth <i>G. tsugae</i>. This discovery provides a key next step in evaluating the active components in their associated herbal supplements