Adjusted dose-response association between daily calcium supplement intake and risk for cardiovascular death.

<p>Calcium supplement intake was coded using an RCS function with four knots arbitrarily located at the 0.05, 0.35, 0.65, and 0.95 percentile. Y-axis represents the adjusted hazard ratio for cardiovascular death for any value of calcium supplement/dietary intake compared to individuals with 0 mg per day intake. Dashed lines are 95% confidence intervals. Knots are represented by dots.</p

Hazard Ratios and 95%Confidence Intervals for risk of cardiovascular death by serum, dietary, supplement, and total calcium.

1<p>Adjusted for: age, sex, race/ethnicity, poverty to income ratio, comorbidity index, serum vitamin D, alcohol consumption, smoking behaviour, vigorous physical activity, and BMI.</p>2<p>Adjusted for: age, sex, race/ethnicity, poverty to income ratio, comorbidity index, serum vitamin D, alcohol consumption, smoking behaviour, vigorous physical activity, total energy intake, and BMI.</p

Baseline characteristics of study population by vital status.

<p>Baseline characteristics of study population by vital status.</p

Adjusted dose-response association between daily dietary calcium intake and risk for cardiovascular death.

<p>Calcium intake was coded using an RCS function with four knots arbitrarily located at the 0.05, 0.35, 0.65, and 0.95 percentile. Y-axis represents the adjusted hazard ratio for cardiovascular death for any value of calcium supplement/dietary intake compared to individuals with 1000 mg per day intake. Dashed lines are 95% confidence intervals. Knots are represented by dots.</p

Table_1_Prevalence of a large panel of systemic autoantibodies in the Bavarian adult population.xlsx

ObjectiveAutoimmune diseases commonly feature the presence of specific humoral autoantibodies. However, the prevalence of a large panel of systemic autoantibodies has never been assessed in the general population. We, therefore, described the prevalence of about 50 humoral systemic autoantibodies in a sample of the general Bavarian adult population.MethodsNon-fasting venous serum samples from 331 participants were analyzed for 7 autoantibody screening tests (nuclear, cytoplasmic, and mitotic ANA, ANCA, cANCA and pANCA, anti-ENA autoantibodies) and 44 different monospecific humoral non-organ specific/systemic autoantibodies using indirect immunofluorescence tests, ELISAs, and line blots. In order to assess associations between sex, age, BMI, education level, smoking status and the presence of systemic autoantibodies, logistic regression analyses were conducted.ResultsAt least one screening test was positive in 29.9% of the participants, and 42.3% of the participants were seropositive for at least one monospecific autoantibody. The most frequently found monospecific autoantibodies were rheumatoid factor (35.6%), ß2-glycoprotein 1 IgM (4.8%), and cardiolipin IgG (1.8%). Only few associations between sex, age, BMI, education, smoking status and autoantibody frequencies were observed.ConclusionSystemic autoantibodies are common in the general Bavarian population, and largely independent of sex, age, BMI, education, or smoking status. The study results may give orientation to clinicians about the occurrence of autoantibodies in the population, not (yet) associated with clinical symptoms.</p

Table_1_Depression mediates the association between health literacy and health-related quality of life after myocardial infarction.docx

IntroductionSo far, health literacy (HL) and its related factors in patients with acute myocardial infarction received little attention. Thus, the objective of this study was to investigate the associations between the different dimensions of HL and disease-specific health-related quality of life (HRQOL), and factors that may affect these relations in patients after acute myocardial infarction (AMI).MethodsAll survivors of AMI between June 2020 and September 2021, from the Myocardial Infarction Registry Augsburg (n=882) received a postal questionnaire on HL [Health Literacy Questionnaire (HLQ)], HRQOL (MacNew Heart Disease HRQOL questionnaire) and depression (Patient Health Questionnaire). From the 592 respondents, 546 could be included in the analysis. Multivariable linear regression models were performed to investigate the associations between the nine subscales of the HLQ and the total score and three subscales of the MacNew questionnaire. A mediation analysis was performed to estimate direct and indirect effects of HL on HRQOL taking into account the mediating effect of depression.ResultsIn the sample of 546 patients (72.5% male, mean age 68.5 ± 12.2 years), patients with poor education showed significantly lower HLQ scores. Significant associations between the subscales of the HLQ and the MacNew were found, which remained significant after adjustment for sociodemographic variables with few exceptions. More than 50% of the association between HL and HRQOL was mediated by depression in seven HLQ subscales and a complete mediating effect was found for the HLQ subscales ‘Actively managing my health’ and ‘Appraisal of health information’.DiscussionDepression mediates the associations between HL and disease-specific HRQOL in patients with myocardial infarction.</p

Additional file 4: of New indexes of body fat distribution and sex-specific risk of total and cause-specific mortality: a prospective cohort study

Different anthropometric measures and cancer mortality. Hazard ratios (HR) and confidence intervals (CI) for the association between the different anthropometric measures and cancer mortality for persons <=/> 60 years by quartiles; the second quartile was set as the reference category. (DOCX 21 kb

Sex-specific RR of stroke for the different obesity measures by quartiles and top 10% (≥90^th percentiles); reference category: Bottom quartile.

<p>Sex-specific RR of stroke for the different obesity measures by quartiles and top 10% (≥90^th percentiles); reference category: Bottom quartile.</p

Odds ratio and 95% confidence interval for association of polymorphisms in selected selenoproteins with prostate cancer risk in strata of disease stage.

<p>OR, 95% confidence interval (CI) and P values were calculated for each SNP analysed using logistic regression and stratified according to disease stage. For each SNP, ORs are presented with reference to the most frequent homozygous genotype.</p

Kaplan Meier survival curves for women (n = 1832, in red, at the top) and men (n = 1917, in blue, at the bottom).

<p>Dashed lines are 95% CI. Factor is sex, outcome is incident stroke, logrank test 10.8 on 1 df, p<0.00099.</p