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    List otwarty Przewodnicz膮cego Zarz膮du G艂贸wnego Polskiego Towarzystwa Onkologicznego

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    Review of Polish and international guidelines on hormonal therapy in localized prostate cancer

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    Prostate cancer is the second most common male malignancy in Poland. We present guidelines of Polish and international oncology and urology societies on hormonal therapy for localized prostate cancer

    Chemotherapy for advanced colorectal patients: daily practice results may not reflect the outcomes of prospective clinical trials

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    Introduction. Colorectal cancer is the second cause of cancer deaths worldwide. The development of new drugs in recent years has improved the outcomes, but it is not clear whether this progress also includes patients managed in daily clinical practice. Treatment outcomes in patients with advanced colorectal cancer treated in Poland outside of clinical trials are scare. Methods. We analyzed the results of first-line chemotherapy in 165 patients with advanced colorectal cancer treated between May 2010 and December 2013 in two institutions. Results. The mean patient age was 61 卤 8.7 years; 105 patients received irinotecan-based regimens (CLF1 or XELIRI), 41 oxaliplatin-based regimens (FOLFOX4 or XELOX) and 19 patients received single-agent 5-fluorouracil. A partial response was achieved in 48 patients (29%), stable disease in 71 (43%) and 46 patients (28%) progressed during treatment. Median survival in the entre group was 14 months. Respective average response rate and median overall survival in recent clinical trials were 39% and 17 months, respectively. Compared to single agent treatment, multidrug chemotherapy was associated with increased general toxicity (p = 0.039), in particular with higher occurrence of diarrhea (p = 0.003) and peripheral neuropathy (p < 0.001). There was no apparent impact of chemotherapy on overall quality of life. Conclusions. Treatment results of advanced colorectal cancer in daily practice may be worse than those obtained in prospective clinical trials. The use of palliative chemotherapy has no noticeable impact on quality of life

    Przyzwojak k艂臋bka szyjnego. Opis przypadku dw贸ch chorych poddanych radioterapii z modulacj膮 intensywno艣ci dawki (IMRT)

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    Paraganglioma of the head and neck is a very rare tumor originating from paraganglionic cells of the chemoreceptor system. The disease has a rich symptomatology. The article presents two patients treated with intensity modulated radiation therapy (IMRT). In one patient paraganglioma was localized bilaterally, which is a particularly rare occurrence. We also presented current literature on paraganglioma treatment, addressing the effectiveness of radiotherapy compared to surgery. Onkol. Prak. Klin. 2011; 7, 5: 274–277Przyzwojak (paraganglioma) to bardzo rzadki nowotw贸r wywodz膮cy si臋 z kom贸rek przyzwojowych uk艂adu chemoreceptorowego. Choroba posiada bogat膮 symptomatologi臋. W artykule przedstawiono dwa przypadki chorych na przyzwojaka szyi poddanych radioterapii technik膮 modulacji intensywno艣ci dawki (IMRT). U jednego z chorych guz by艂 zlokalizowany obustronnie, co jest szczeg贸lnie rzadkim zjawiskiem. Omawiane przypadki przedstawiono na tle doniesie艅 dotycz膮cych skuteczno艣ci radioterapii przyzwojaka w por贸wnaniu z leczeniem chirurgicznym. Onkol. Prak. Klin. 2011; 7, 5: 274–27
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