Distribution of outcomes in case of exposure.

<p>Distribution of outcomes in case of contact with an infectious person according to immunological status. Values for susceptible, immune and natural waning are taken from <i>Van Rie et al.</i><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0006284#pone.0006284-Coudeville1" target="_blank">[25]</a>. Values for vaccine-related compartments are estimated using <i>Bisgard et al.</i><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0006284#pone.0006284-Bisgard2" target="_blank">[<i>31</i>]</a> and <i>Ward et al.</i><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0006284#pone.0006284-Ward1" target="_blank">[10]</a>. Figures in parentheses define the range used in the sensitivity analysis.</p

Key parameters in the epidemiological model.

<p>Key parameters in the epidemiological model.</p

Estimates for the short term cost per case of pertussis infection (ranges used in sensitivity analyzes presented in parentheses).

*<p>Applies only to the fraction of patients with long term sequelae following infection.</p>**<p>Applies only to the fraction of patients with fatal cases of pertussis or long term sequelae following infection.</p>+<p>Caro et al. [43] updated to 2006 using CPI for medical care (<a href="http://www.bls.gov" target="_blank">www.bls.gov</a>).</p>#<p>Lee et al. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0006284#pone.0006284-Lee1" target="_blank">[20]</a> updated to 2006 using CPI for medical care (<a href="http://www.bls.gov" target="_blank">www.bls.gov</a>).</p

Variation in pertussis incidence and costs according to the age at which the adult booster dose is administered (Childhood vaccination+adolescent+cocoon+1 booster dose for adult vaccination - steady-state situation).

<p>Variation in pertussis incidence and costs according to the age at which the adult booster dose is administered (Childhood vaccination+adolescent+cocoon+1 booster dose for adult vaccination - steady-state situation).</p

Average annual predicted costs of pertussis and vaccination from 2006 to 2106.

<p>Average annual predicted costs of pertussis and vaccination from 2006 to 2106.</p