44 research outputs found

    A method for generating developments using decomposition into the meaningful components of 3D polygon models

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    We propose a method for generating developments from 3D polygon models automatically. The conventional method generates the developments whose components are not interfering each together, by using collision detection between all polygons. However, for the model which consists of a large number of polygons, it is necessary to decompose the development into several parts manually. Therefore it is difficult to generate the development which is easy to be assembled. Our method decomposes the polygon model into meaningful components such as arms, legs, and so on, and develops them. This makes it easy to understand which parts should be glued together, and handcraft bending or folding the developments when a user assembles the paper craft

    Prospective study of daily low-dose nedaplatin and continuous 5-fluorouracil infusion combined with radiation for the treatment of esophageal squamous cell carcinoma

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    <p>Abstract</p> <p>Background</p> <p>Protracted low-dose concurrent chemotherapy combined with radiation has been proposed for enhanced treatment results for esophageal cancer. We evaluated the efficacy and the toxicity of a novel regimen of daily low-dose nedaplatin (cis-diammine-glycolatoplatinum) and continuous infusion of 5-fluorouracil (5-FU) with radiation in patients with esophageal squamous cell carcinoma.</p> <p>Methods</p> <p>Between January 2003 and June 2008, 33 patients with clinical stage I to IVB esophageal squamous cell carcinoma were enrolled. Nedaplatin (10 mg/body/day) was administered daily and 5-FU (500 mg/body/day) was administered continuously for 20 days. Fractionated radiotherapy for a total dose of 50.4-66 Gy was administered together with chemotherapy. Additional chemotherapy with nedaplatin and 5-FU was optionally performed for a maximum of 5 courses after chemoradiotherapy. The primary end-point of this study was to evaluate the tumor response, and the secondary end-points were to evaluate the toxicity and the overall survival.</p> <p>Results</p> <p>Twenty-two patients (72.7%) completed the regimen of chemoradiotherapy. Twenty patients (60.6%) achieved a complete response, 10 patients (30.3%) a partial response. One patient (3.0%) had a stable disease, and 2 (6.1%) a progressive disease. The overall response rate was 90.9% (95% confidence interval: 75.7%-98.1%). For grade 3-4 toxicity, leukopenia was observed in 75.8% of the cases, thrombocytopenia in 24.2%, anemia in 9.1%, and esophagitis in 36.4%, while late grade 3-4 cardiac toxicity occurred in 6.1%. Additional chemotherapy was performed for 26 patients (78.8%) and the median number of courses was 3 (range, 1-5). The 1-, 2- and 3-year survival rates were 83.9%, 76.0% and 58.8%, respectively. The 1- and 2-year survival rates were 94.7% and 88.4% in patients with T1-3 M0 disease, and 66.2% and 55.2% in patients with T4/M1 disease.</p> <p>Conclusion</p> <p>The treatment used in our study may yield a high complete response rate and better survival for each stage of esophageal squamous cell carcinoma.</p> <p>Trial registration</p> <p>ClinicalTrials.gov Identifier: NCT00197444</p

    A method for generating developments using decomposition into the meaningful components of 3D polygon models

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    We propose a method for generating developments from 3D polygon models automatically. The conventional method generates the developments whose components are not interfering each together, by using collision detection between all polygons. However, for the model which consists of a large number of polygons, it is necessary to decompose the development into several parts manually. Therefore it is difficult to generate the development which is easy to be assembled. Our method decomposes the polygon model into meaningful components such as arms, legs, and so on, and develops them. This makes it easy to understand which parts should be glued together, and handcraft bending or folding the developments when a user assembles the paper craft

    Removal of NF3 from semiconductor process flue gases by tandem packed bed plasma-adsorbent hybrid systems

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    [[abstract]]This study focuses on NF3 removal by a tandem hybrid system comprised by a BaTiO3 packed-bed plasma reactor and adsorbent filter. Detailed plasma chemical kinetics in O2-H2-N2-NF3 gas mixture and by-product analysis are presented. The laboratory-scale atmospheric pressure packed-bed plasma reactor/adsorbent filter hybrid system for NF3 removal is successfully demonstrated. A 100% removal efficiency is achieved by the hybrid system for 5000 ppm NF3 and residence time less than 10 sec.[[fileno]]2030213030045[[department]]資訊工程學

    Supplementary Material for: Guggulsterone, a Plant-Derived Inhibitor of NF-TB, Suppresses CDX2 and COX-2 Expression and Reduces the Viability of Esophageal Adenocarcinoma Cells

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    <b><i>Background/Aims:</i></b> Induction by bile acid of caudal type homeobox 2 (CDX2) and cyclooxygenase-2 (COX-2) expression via nuclear factor-TB (NF-TB) activation is a critical event in the development of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC). Guggulsterone (GS) is a plant sterol that inhibits NF-TB activity. Here, we evaluated whether GS has either or both chemopreventive or therapeutic effects against EAC. <b><i>Methods:</i></b> Two EAC cells lines were treated with deoxycholic acid (DCA) in the presence of GS or vehicle. The levels of transcription and translation of <i>ITBE</i>, <i>CDX2</i>, and <i>COX-2</i> were determined. Prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) levels, cell viability, and cell cycle distribution were assessed as well. <b><i>Results:</i></b> GS inhibited DCA-induced ITBE phosphorylation. GS and the NF-TB inhibitor BAY11-7085 suppressed DCA-induced <i>CDX2</i> and <i>COX-2</i> expression in EAC cells. GS also suppressed basal transcription levels of <i>CDX2</i> and <i>COX-2</i> and reduced constitutive synthesis of COX-2 and PGE<sub>2</sub>. Further, GS reduced the viability of EAC cells, increased their numbers in the apoptotic sub-G1 fraction. <b><i>Conclusion:</i></b> GS suppressed DCA-induced and NF-TB-dependent activation of <i>CDX2</i> and <i>COX-2</i> expression. Further, GS also reduced the viability of EAC cells. GS may serve as candidate for preventing and treating EAC and BE. i 2014 S. Karger AG, Base
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