1 research outputs found
Herbicidin Congeners, Undecose Nucleosides from an Organic Extract of <i>Streptomyces</i> sp. L‑9-10
Four new undecose nucleosides (herbicidin
congeners), three known
herbicidins, and 9-(β-d-arabinofuranosyl)Âhypoxanthine
(Ara-H) were isolated from the organic extract of a fermentation culture
of <i>Streptomyces</i> sp. L-9-10 using proton NMR-guided
fractionation. Their structures were elucidated on the basis of comprehensive
1D and 2D NMR and mass spectrometry analyses. These structures included
2′-<i>O</i>-demethylherbicidin F (<b>1</b>),
9′-deoxy-8′,8′-dihydroxyherbicidin B (<b>2</b>), 9′-deoxy-8′-oxoherbicidin B (<b>2a</b>), and
the 8′-epimer of herbicidin B (<b>3</b>). This is the
first detailed assignment of proton and carbon chemical shifts for
herbicidins A, B, and F. The isolated compounds were evaluated for
cancer chemopreventive potential based on inhibition of tumor necrosis
factor alpha (TNF-α)-induced nuclear factor-kappa B (NF-κB)
activity