Recent Expansion of Gubernatorial Emergency Powers to Address the COVID-19 Pandemic: Examining Applications for the Climate Crisis

With a particular focus on the states of California and Florida, this Note delves into the leadership roles assumed by governors when addressing the global COVID-19 pandemic, evaluates the applicability of this gubernatorial strategy to the climate crisis, and examines the criticisms and constitutional challenges to expanding gubernatorial emergency powers. Part I explores the core similarities and differences between the COVID-19 pandemic and climate change. Part II addresses the failure of federal and international policy responses to both the pandemic and climate change. Part III details the states’ use of gubernatorial emergency powers to respond to COVID-19. Part IV then evaluates the viability of using gubernatorial emergency powers as a means of responding to climate change. Finally, Part V addresses the criticisms and constitutional challenges to expanding these gubernatorial powers. Ultimately, this Note aims to explore whether gubernatorial emergency powers, a vital tool used during the pandemic, could also be used to address climate change at a state level. This abstract has been taken from the author\u27s introduction

A construção do herói na tradição oral da África Ocidental

O estudo da história africana tem ganhado relevo graças a destacados trabalhos que tem contribuído para desmistificar essa temática e superar preconceitos, ampliando, desta forma, os horizontes do conhecimento, e colocando ao alcance de pesquisadores e estudantes uma enorme gama de elementos constituintes de uma cultura rica e diversificada: a cultura africana. Neste trabalho, trataremos de discutir a respeito de uma constante que se verifica em algumas tradições da África ocidental sudanesa: o mito de origem de impérios através da figura de um herói fundador, partindo da análise da trajetória de Sundjata Keita, herói de muitos nomes do reino Mandinga, comparada a de Samba Gueladio Diegui, príncipe peul de Futa. Nossa análise parte da obra de Djibril Tamsir Niane, Sundjata ou a epopéia mandinga. Pela própria natureza da fonte pesquisada, tem destaque à questão da oralidade e sua grande importância para diversas sociedades tradicionais africanas, através da figura dos griots, que será também trabalhada nas páginas deste texto. Finalmente, longe de encerrar alguma discussão, este trabalho se pretende contribuinte de uma busca mais ampla, que mais do que nunca se faz necessária, pelo passado e pela história de uma cultura complexa e suntuosa, que poderá trazer, ainda, muitos frutos e valorosos conhecimentos

Comparison of 8 weeks standard treatment (rifampicin plus clarithromycin) vs. 4 weeks standard plus amoxicillin/clavulanate treatment [RC8 vs. RCA4] to shorten Buruli ulcer disease therapy (the BLMs4BU trial): study protocol for a randomized controlled multi-centre trial in Benin

Background Buruli ulcer (BU) is a neglected tropical disease caused by Mycobacterium ulcerans that affects skin, soft tissues, and bones, causing long-term morbidity, stigma, and disability. The recommended treatment for BU requires 8 weeks of daily rifampicin and clarithromycin together with wound care, physiotherapy, and sometimes tissue grafting and surgery. Recovery can take up to 1 year, and it may pose an unbearable financial burden to the household. Recent in vitro studies demonstrated that beta-lactams combined with rifampicin and clarithromycin are synergistic against M. ulcerans. Consequently, inclusion of amoxicillin/clavulanate in a triple oral therapy may potentially improve and shorten the healing process. The BLMs4BU trial aims to assess whether co-administration of amoxicillin/clavulanate with rifampicin and clarithromycin could reduce BU treatment from 8 to 4 weeks. Methods We propose a randomized, controlled, open-label, parallel-group, non-inferiority phase II, multi-centre trial in Benin with participants stratified according to BU category lesions and randomized to two oral regimens: (i) Standard: rifampicin plus clarithromycin therapy for 8 weeks; and (ii) Investigational: standard plus amoxicillin/clavulanate for 4 weeks. The primary efficacy outcome will be lesion healing without recurrence and without excision surgery 12 months after start of treatment (i.e. cure rate). Seventy clinically diagnosed BU patients will be recruited per arm. Patients will be followed up over 12 months and managed according to standard clinical care procedures. Decision for excision surgery will be delayed to 14 weeks after start of treatment. Two sub-studies will also be performed: a pharmacokinetic and a microbiology study. Discussion If successful, this study will create a new paradigm for BU treatment, which could inform World Health Organization policy and practice. A shortened, highly effective, all-oral regimen will improve care of BU patients and will lead to a decrease in hospitalization-related expenses and indirect and social costs and improve treatment adherence. This trial may also provide information on treatment shortening strategies for other mycobacterial infections (tuberculosis, leprosy, or non-tuberculous mycobacteria infections)

The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

INTRODUCTION Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic. RATIONALE We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs). RESULTS Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants. CONCLUSION Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century

Student Assessment of Quality of Access at the National Open University of Nigeria (NOUN)

This paper presents a study conducted by Inegbedion, Adu and Ofulue from the National Open University of Nigeria. The study focused on the quality of access (admission and registration) at NOUN from a student perspective. A survey design was used for the study while a multi-stage sampling technique was used to select the sample size. All the 78,555 registered students in all the 61 Study Centres of the University at the time of the study formed the population; out of which 3,060 students were sampled. The questionnaire instrument is the Institutional Internal QA Tools and Instrument developed by the African Council for Distance Education (ACDE) as a regulatory mechanism. The data collected were analyzed using simple statistics. The result showed that 66% of the students confirmed that NOUN has published clear policies on the admission and registration of students. About 29.1% of the students were not satisfied with the transparency of the admission process. In conclusion, the study revealed high quality of access and some deficiencies in website and Internet connectivity

Influence of beliefs about cervical cancer etiology on Pap smear use among Latina immigrants.

ObjectiveTo assess Latina immigrants' beliefs about the role of sexual activities in cervical cancer etiology and the impact of the beliefs on Papanicolaou (Pap) smear use. Previous research has found that Latinas, particularly immigrants, believe that cervical cancer is related to 'unwise' sexual activities; however, their beliefs about the nature of the relationship are unclear.DesignWe conducted semi-structured face-to-face interviews with a non-probability purposive sample of 20 Mexican immigrant women who resided in Orange County, California regarding their beliefs about risk factors for cervical cancer and Pap smear use. We used qualitative content analysis to identify major themes. Three investigators independently reviewed transcripts of the audio-taped interviews to identify themes and came to a consensus about them.ResultsThe women had a mean age of 39 years and had resided in the USA for an average of 16.3 years. We identified several themes. The majority of respondents had limited knowledge about cervical cancer and no knowledge about human papillomavirus (HPV); believed that infections caused by physical trauma, certain sexual activities, and poor hygiene caused cervical cancer; believed that they only needed a Pap smear if they developed symptoms of a pelvic infection; and felt that women who engaged in 'unwise' sexual behaviors, in particular, should receive regular Pap smear exams.ConclusionThe results suggest that culturally related beliefs about the etiology of cervical cancer play a role in the decision to obtain Pap smears for Latina immigrants. The findings may help to explain why researchers have found Latino ethnicity to be an independent predictor of Pap smear use. They also suggest that programs designed to improve cervical cancer screening, particularly among Latina immigrants, should stress the nature of HPV transmission, its role in the etiology of cervical cancer, and the importance of Pap smear screening in the absence of symptoms