Rocket Science at the Nanoscale

Autonomous propulsion at the nanoscale represents one of the most challenging and demanding goals in nanotechnology. Over the past decade, numerous important advances in nanotechnology and material science have contributed to the creation of powerful self-propelled micro/nanomotors. In particular, micro- and nanoscale rockets (MNRs) offer impressive capabilities, including remarkable speeds, large cargo-towing forces, precise motion controls, and dynamic self-assembly, which have paved the way for designing multifunctional and intelligent nanoscale machines. These multipurpose nanoscale shuttles can propel and function in complex real-life media, actively transporting and releasing therapeutic payloads and remediation agents for diverse biomedical and environmental applications. This review discusses the challenges of designing efficient MNRs and presents an overview of their propulsion behavior, fabrication methods, potential rocket fuels, navigation strategies, practical applications, and the future prospects of rocket science and technology at the nanoscale

Swimming Microrobot Optical Nanoscopy

Optical imaging plays a fundamental role in science and technology but is limited by the ability of lenses to resolve small features below the fundamental diffraction limit. A variety of nanophotonic devices, such as metamaterial superlenses and hyperlenses, as well as microsphere lenses, have been proposed recently for subdiffraction imaging. The implementation of these micro/nanostructured lenses as practical and efficient imaging approaches requires locomotive capabilities to probe specific sites and scan large areas. However, directed motion of nanoscale objects in liquids must overcome low Reynolds number viscous flow and Brownian fluctuations, which impede stable and controllable scanning. Here we introduce a new imaging method, named swimming microrobot optical nanoscopy, based on untethered chemically powered microrobots as autonomous probes for subdiffraction optical scanning and imaging. The microrobots are made of high-refractive-index microsphere lenses and powered by local catalytic reactions to swim and scan over the sample surface. Autonomous motion and magnetic guidance of microrobots enable large-area, parallel and nondestructive scanning with subdiffraction resolution, as illustrated using soft biological samples such as neuron axons, protein microtubulin, and DNA nanotubes. Incorporating such imaging capacities in emerging nanorobotics technology represents a major step toward ubiquitous nanoscopy and smart nanorobots for spectroscopy and imaging

Self-Propelled Nanomotors Autonomously Seek and Repair Cracks

Biological self-healing involves the autonomous localization of healing agents at the site of damage. Herein, we design and characterize a synthetic repair system where self-propelled nanomotors autonomously seek and localize at microscopic cracks and thus mimic salient features of biological wound healing. We demonstrate that these chemically powered catalytic nanomotors, composed of conductive Au/Pt spherical Janus particles, can autonomously detect and repair microscopic mechanical defects to restore the electrical conductivity of broken electronic pathways. This repair mechanism capitalizes on energetic wells and obstacles formed by surface cracks, which dramatically alter the nanomotor dynamics and trigger their localization at the defects. By developing models for self-propelled Janus nanomotors on a cracked surface, we simulate the systems’ dynamics over a range of particle speeds and densities to verify the process by which the nanomotors autonomously localize and accumulate at the cracks. We take advantage of this localization to demonstrate that the nanomotors can form conductive “patches” to repair scratched electrodes and restore the conductive pathway. Such a nanomotor-based repair system represents an important step toward the realization of biomimetic nanosystems that can autonomously sense and respond to environmental changes, a development that potentially can be expanded to a wide range of applications, from self-healing electronics to targeted drug delivery

Highly Efficient Freestyle Magnetic Nanoswimmer

The unique swimming strategies of natural microorganisms have inspired recent development of magnetic micro/nanorobots powered by artificial helical or flexible flagella. However, as artificial nanoswimmers with unique geometries are being developed, it is critical to explore new potential modes for kinetic optimization. For example, the freestyle stroke is the most efficient of the competitive swimming strokes for humans. Here we report a new type of magnetic nanorobot, a symmetric multilinked two-arm nanoswimmer, capable of efficient “freestyle” swimming at low Reynolds numbers. Excellent agreement between the experimental observations and theoretical predictions indicates that the powerful “freestyle” propulsion of the two-arm nanorobot is attributed to synchronized oscillatory deformations of the nanorobot under the combined action of magnetic field and viscous forces. It is demonstrated for the first time that the nonplanar propulsion gait due to the cooperative “freestyle” stroke of the two magnetic arms can be powered by a plane oscillatory magnetic field. These two-arm nanorobots are capable of a powerful propulsion up to 12 body lengths per second, along with on-demand speed regulation and remote navigation. Furthermore, the nonplanar propulsion gait powered by the consecutive swinging of the achiral magnetic arms is more efficient than that of common chiral nanohelical swimmers. This new swimming mechanism and its attractive performance opens new possibilities in designing remotely actuated nanorobots for biomedical operation at the nanoscale

Self-Propelled Nanomotors Autonomously Seek and Repair Cracks

Biological self-healing involves the autonomous localization of healing agents at the site of damage. Herein, we design and characterize a synthetic repair system where self-propelled nanomotors autonomously seek and localize at microscopic cracks and thus mimic salient features of biological wound healing. We demonstrate that these chemically powered catalytic nanomotors, composed of conductive Au/Pt spherical Janus particles, can autonomously detect and repair microscopic mechanical defects to restore the electrical conductivity of broken electronic pathways. This repair mechanism capitalizes on energetic wells and obstacles formed by surface cracks, which dramatically alter the nanomotor dynamics and trigger their localization at the defects. By developing models for self-propelled Janus nanomotors on a cracked surface, we simulate the systems’ dynamics over a range of particle speeds and densities to verify the process by which the nanomotors autonomously localize and accumulate at the cracks. We take advantage of this localization to demonstrate that the nanomotors can form conductive “patches” to repair scratched electrodes and restore the conductive pathway. Such a nanomotor-based repair system represents an important step toward the realization of biomimetic nanosystems that can autonomously sense and respond to environmental changes, a development that potentially can be expanded to a wide range of applications, from self-healing electronics to targeted drug delivery