A Convenient FeCl₃-Catalyzed Hydroarylation of Styrenes

1,1-Diarylalkanes are easily synthesized by CH-functionalization reactions of electron-rich arenes and heteroarenes with styrenes in the presence of FeCl3 as catalyst

A Convenient FeCl₃-Catalyzed Hydroarylation of Styrenes

1,1-Diarylalkanes are easily synthesized by CH-functionalization reactions of electron-rich arenes and heteroarenes with styrenes in the presence of FeCl3 as catalyst

MOESM1 of Safety of a single low-dose of primaquine in addition to standard artemether-lumefantrine regimen for treatment of acute uncomplicated Plasmodium falciparum malaria in Tanzania

Additional file 1: Characteristics of patients with acute haemolytic anaemia during the trial

Distribution of quantitative PCR determined parasite densities.

<p>pan- <i>Pan plasmodium</i>, Geometric mean values are indicated by horizontal lines. Geometric mean values are for PCR + 1.8 p/μL (range 0.1–770), for PCR+/ pan HTP-LAMP + 2.5 p/μL (range 0.2–770), for PCR+/ pan-HTP-LAMP– 1.4 p/μL (range 0.1–7) and for Chelex pan-LAMP + 3.4 p/μL (range 0.1–770).</p

Flow chart of high-throughput (HTP)-LAMP evaluation.

<p>Results of Pan <i>Plasmodium</i> HTP-LAMP, confirmed PCR and Chelex LAMP (Ch-LAMP) are summarized. spp-species.</p

Characterization of HTP-LAMP positive blood samples (N = 22).

<p>Characterization of HTP-LAMP positive blood samples (N = 22).</p

Characterization of HTP-LAMP versus PCR discordant samples for diagnosis of <i>Plasmodium</i> infection (N = 31).

<p>Characterization of HTP-LAMP versus PCR discordant samples for diagnosis of <i>Plasmodium</i> infection (N = 31).</p

Diagnostic accuracy of Malaria pan HTP-LAMP compared to PCR for 3008 field samples.

<p>Diagnostic accuracy of Malaria pan HTP-LAMP compared to PCR for 3008 field samples.</p

Detection of LAMP result under UV light.

<p>N- negative, P- positive, NC-negative control, PC- positive control.</p

Additional file 2: of A cluster randomised controlled trial of two rounds of mass drug administration in Zanzibar, a malaria pre-elimination setting—high coverage and safety, but no significant impact on transmission

Figure S1. Capillary whole blood piperaquine concentrations at day 7 post-dose, stratified by self-reported adherence status. Figure S2. Number of clinical malaria cases as reported through the malaria case notification system from January 2015 to Sept 2017 in Unguja. Figure S3. Weekly number of clinical malaria cases as reported in the Malaria Early Epidemic Detections System in Unguja 2016. (PDF 414 kb