2,921 research outputs found

    Orthostatic intolerance and autonomic dysfunction following bariatric surgery: A retrospective study and review of the literature

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    The prevalence and costs of the obesity epidemic and obesity-related conditions, including diabetes mellitus, is consistently increasing worldwide. Bariatric medicine is attempting to address this with weight loss and exercise programmes, and with increasing frequency, various forms of bariatric surgery. There has been considerable success reported after bariatric surgery but not without. We describe 14 patients with orthostatic intolerance (OI) post bariatric surgery. We report on OI (postural dizziness, palpitations and fainting), the results of cardiovascular autonomic testing and the associated and/or causative findings as well as reviewing the literature to consider the possible mechanisms. Comprehensive autonomic testing revealed that 35.7% (Buchwald et al., 2004) of these patients fulfilled the criteria for the Postural Tachycardia Syndrome (PoTS), 57.1% (Cremieux et al., 2008) had low levels of basal BP and 42.9% (Cammisotto & Bendayan, 2007) patients were presyncopal and 14.3% (Billakanty et al., 2008) experienced syncope. We propose that the incidence of OI post-bariatric surgery is higher than considered, that certain cohorts may be more susceptible to complications, and that further research is needed to identify the prevalence and, ideally anticipate occurrence. With the increasing prevalence of obesity and required clinical interventions, further understanding of the pathophysiological processes causing autonomic dysfunction after bariatric interventions will aid management, which may differ in those with an underlying disposition to autonomic involvement, such as diabetics, in whom such procedures are increasingly used

    Phenotypic effects of expanded ataxin-1 polyglutamines with interruptions in vitro

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    Spinocerebellar ataxia type 1 is a neurodegenerative disease caused by expansion of an uninterrupted glutamine repeat in ataxin-1 protein. Protein aggregation and immunoreactivity to 1C2 monoclonal antibody are two distinct pathognomonic features of expanded ataxin-1, as well as of other polyglutamine disorders. Rare cases of non-affected elderly subjects carrying expanded ataxin-1 alleles were found in random population. However, in these alleles the glutamine stretch was interrupted by histidines. Due to lack of phenotype, these alleles should be considered "normal". Most importantly, occurrence of these unusual alleles provides a unique opportunity to investigate which molecular properties of expanded ataxin-1 are not coupled to polyglutamine pathogenesis. Towards this goal, we compared in vitro the immunoreactivity to 1C2 antibody and the ability to form aggregates of interrupted and uninterrupted alleles. Immunoblotting showed that expanded-interrupted ataxin-1 had an affinity to 1C2 resembling that of normal ataxin-1. On the contrary, filter assay showed that aggregation rate of expanded-interrupted ataxin-1 resembles that of expanded-uninterrupted ataxin-1. These observations indicate that affinity for 1C2 does not directly correlate with self-aggregation of ataxin-1. Moreover, self-aggregation is not directly affected by histidine interruptions. In conclusion, these results support the hypothesis that mechanisms underlying neuronal degeneration are triggered by protein misfolding rather than by protein aggregation

    AM 1934-563: A giant spiral polar-ring galaxy in a triplet

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    We have observed the emission-line kinematics and photometry of a southern triplet of galaxies. The triplet contains a giant spiral galaxy AM 1934-563 which optical structure resembles a polar-ring galaxy: distorted spiral disk, seen almost edge-on, and a faint large-scale (45 kpc in diameter) warped structure, inclined by 60^o-70^o with respect to the disk major axis. The triplet shows relatively small velocity dispersion (69 km/s) and a large crossing time (0.17 in units of the Hubble time). The disk of AM 1934-563 demonstrates optical colors typical for an early-type spirals, strong radial color gradient, and almost exponential surface brightness distribution with an exponential scale-length value of 3.1 kpc (R passband). The galaxy shows a maximum rotation velocity of about 200 km/s and it lies close to the Tully-Fisher relation for spiral galaxies. The suspected polar ring is faint (\mu(B) > 24) and strongly warped. Its total luminosity comprises (10-15)% of the total luminosity of AM 1934-563. We then try to model this system using numerical simulations, and study its possible formation mechanisms. We find that the most robust model, that reproduces the observed characteristics of the ring and the host galaxy, is the tidal transfer of mass from a massive gas-rich donor galaxy to the polar ring. The physical properties of the triplet of galaxies are in agreement with this scenario.Comment: Accepted for publication in A&

    VEGAS: a VST Early-type GAlaxy Survey. IV. NGC 1533, IC 2038 and IC 2039: an interacting triplet in the Dorado group

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    This paper focuses on NGC 1533 and the pair IC 2038 and IC 2039 in Dorado a nearby, clumpy, still un-virialized group. We obtained their surface photometry from deep OmegaCAM@ESO-VST images in g and r bands. For NGC 1533, we map the surface brightness down to őľg‚ČÉ30.11\mu_g \simeq 30.11 mag/arcsec2^{2} and őľr‚ČÉ28.87\mu_r \simeq 28.87 mag/arcsec2^{2} and out to about 4Re4R_e. At such faint levels the structure of NGC 1533 appear amazingly disturbed with clear structural asymmetry between inner and outer isophotes in the North-East direction. We detect new spiral arm-like tails in the outskirts, which might likely be the signature of a past interaction/merging event. Similarly, IC 2038 and IC 2039 show tails and distortions indicative of their ongoing interaction. Taking advantages of deep images, we are able to detect the optical counterpart to the HI gas. The analysis of the new deep data suggests that NGC 1533 had a complex history made of several interactions with low-mass satellites that generated the star-forming spiral-like structure in the inner regions and are shaping the stellar envelope. In addition, the VST observations show that also the two less luminous galaxies, IC 2038 and IC 2039, are probably interacting each-other and, in the past, IC 2038 could have also interacted with NGC 1533, which stripped away gas and stars from its outskirts. The new picture emerging from this study is of an interacting triplet, where the brightest galaxy NGC 1533 has ongoing mass assembly in the outskirts.Comment: Accepted for publication in The Astronomical Journal. High-resolution version of paper is available at the following link: https://www.dropbox.com/preview/VEGAS_IV.pdf?role=persona

    Polar Ring Galaxies and the Tully Fisher relation: implications for the dark halo shape

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    We have investigated the Tully-Fisher relation for Polar Ring Galaxies (PRGs), based on near infrared, optical and HI data available for a sample of these peculiar objects. The total K-band luminosity, which mainly comes from the central host galaxy, and the measured HI linewidth at 20% of the peak line flux density, which traces the potential in the polar plane, place most polar rings of the sample far from the Tully-Fisher relation defined for spiral galaxies, with many PRGs showing larger HI linewidths than expected for the observed K band luminosity. This result is confirmed by a larger sample of objects, based on B-band data. This observational evidence may be related to the dark halo shape and orientation in these systems, which we study by numerical modeling of PRG formation and dynamics: the larger rotation velocities observed in PRGs can be explained by a flattened polar halo, aligned with the polar ring.Comment: 22 pages, 8 postscript figures, accepted for publication in Astrophysical Journa

    The Fornax Deep Survey with VST. I. The extended and diffuse stellar halo of NGC~1399 out to 192 kpc

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    [Abrigded] We have started a new deep, multi-imaging survey of the Fornax cluster, dubbed Fornax Deep Survey (FDS), at the VLT Survey Telescope. In this paper we present the deep photometry inside two square degrees around the bright galaxy NGC1399 in the core of the cluster. We found a very extended and diffuse envelope surrounding the luminous galaxy NGC1399: we map the surface brightness out to 33 arcmin (~ 192 kpc) from the galaxy center and down to about 31 mag/arcsec^2 in the g band. The deep photometry allows us to detect a faint stellar bridge in the intracluster region between NGC1399 and NGC1387. By analyzing the integrated colors of this feature, we argue that it could be due to the ongoing interaction between the two galaxies, where the outer envelope of NGC1387 on its east side is stripped away. By fitting the light profile, we found that it exists a physical break radius in the total light distribution at R=10 arcmin (~58 kpc) that sets the transition region between the bright central galaxy and the outer exponential stellar halo. We discuss the main implications of this work on the build-up of the stellar halo at the center of the Fornax cluster. By comparing with the numerical simulations of the stellar halo formation for the most massive BCGs, we find that the observed stellar halo mass fraction is consistent with a halo formed through the multiple accretion of progenitors with a stellar mass in the range 10^8 - 10^11 M_sun. This might suggest that the halo of NGC1399 has also gone through a major merging event. The absence of a significant number of luminous stellar streams and tidal tails out to 192 kpc suggests that the epoch of this strong interaction goes back to an early formation epoch. Therefore, differently from the Virgo cluster, the extended stellar halo around NGC1399 is characterised by a more diffuse and well-mixed component, including the ICL.Comment: Accepted for publication in ApJ; 25 pages and 14 figures. An higher resolution file is available at the following link https://www.dropbox.com/s/fvltppduysdn6pb/NGC1399_fin_2c.pdf?dl=

    Association between work related stress and health related quality of life: the impact of socio-demographic variables. A cross sectional study in a region of central Italy

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    The aim of this work is investigate relationship between health-related quality of life and work-related stress and the impact of gender, education level, and age on this relationship. A cross-sectional study was conducted among workers of various setting in Rome and Frosinone. Work-related stress was measured with a demand-control questionnaire and health-related functioning by SF (short form)-12 health survey. There were 611 participants. Men reported high mental composite summary (MCS) and physical composite summary (PCS). In multivariate analysis age, gender (p < 0.001) and job demand (0.045) predicted low PCS. Low MCS predicted poor PCS. Job demand and educational level resulted negatively associated with MCS. In an analysis stratified for age, gender, and educational level, gender and age resulted effect modifier for MCS, gender and education level for PCS. In women increase of decision latitude predict (p = 0.001) an increase in MCS; a low job demand predict high MCS in male (p ‚ȧ 0.001). In younger workers, a lower level of job demand predicted high MCS (<0.001). For PCS, gender and education level resulted effect modifier. In women, high decision latitude predicted higher PCS (p = 0.001) and lower level of job demand results in higher PCS (p ‚ȧ 0.001). Higher educational level resulted predictor of low PCS. Management of risk about work-related stress should consider socio-demographic factors
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