Additional file 1 of Liposomes targeting the cancer cell-exposed receptor, claudin-4, for pancreatic cancer chemotherapy

Additional file 1: Figure S1. Storage stability,measured as changes in the size and PDI of D@C-LPs at 4°C and 25°C. Figure S2. Cytotoxicity of Dox-loaded liposomes against various cancer cell lines. Figure S3. In vivo biodistribution of D@C-LP with pre-treatment of CLDN4 antibody. Figure S4. In vivo therapeutic efficacy of Dox-loaded liposomes in a KPC960 xenograft model. A Photographs of excised tumors after treatment. B Ex vivo fluorescence images. C Changes in body weight in treatment groups over the course of 15 days. D H&E staining of major organsafter 15 days. Figure S5. In vivo therapeutic efficacy of Dox-loaded liposomes in a KPC960 orthotopic model. A Average tumor weights of excised primary tumors. B Average tumor weights of excised metastatic tumors. C Changes in body weight in treatment groups over the course of 24 days. D H&E staining of major organsafter 24 days