638 research outputs found

    A measurement of the radiation dose to LDEF by passive dosimetry

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    The results from a pair of thermoluminescent dosimeter experiments flown aboard the Long Duration Exposure Facility (LDEF) show an integrated dose several times smaller than that predicted by the NASA environmental models for shielding thicknesses much greater than 0.10 gm/sq cm aluminum. For thicknesses between 0.01 and 0.1 gm/sq cm, the measured dose was in agreement with predictions. The Space and Environment Technology Center of The Aerospace Corporation fielded two related experiments on LDEF to measure the energetic radiation dose by means of passive dosimetry. The sensors were LiF thermoluminescent dosimeters mounted behind various thicknesses of shielding. The details of the experiment are described first, followed by the results of the observations. A comparison is made with the predictions based upon the NASA environmental models and the actual mission profile flown by LDEF; conclusions follow

    Measurement of energetic particle radiation at the synchronous altitude aboard ATS-6

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    The Aerospace Corporation energetic electron-proton spectrometer operating on ATS-6 is described. This experiment detects energetic electrons in four channels between 140 keV and greater than 3.9 MeV, measures energetic protons in five energy channels between 2.3 and 80 MeV and energetic alpha particles in three channels between 9.4 and 94 MeV. After more than a year of operation in orbit, the experiment continues to return excellent data on the behavior of energetic magnetospheric electrons as well as information regarding the fluxes of solar protons and alpha particles

    Cosmic ray simulation and testing program

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    Single event upset (SEU) and latchup vulnerabilities were determined for a number of parts of interest to NASA space programs. In cases where a threshold linear energy transfer (LET) for SEU could be measured, an upset rate in a low inclination Space Shuttle orbit was computed. The predicted upset rates are extremely low, except for the devices with LET thresholds below the geomagnetic cutoff for altitude and inclination of the Space Shuttle orbit. While some of the devices do exhibit latchup, the cross sections and threshold LETs are such that the risk associated with flying these devices in low, near equatorial orbits is small if not negligible

    A battery charging system for intermittent generation from a synchronous generator with a novel maximum power point tracking control

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    This paper proposed a battery charging system for intermittent generation from a synchronous generator with a novel Maximum Power Point Tracking (MPPT) control method. Analyzing the generation with boost chopper by the state space averaging method, the internal voltage of the generator, the output voltage and the resistance of the output of the boost chopper can be estimated by with only single current sensor. Even though the intermittent generation, the proposed the battery charging system is able to charge the battery constantly because of a bi-directional DC/DC converter and an Electric Double-Layer Capacitor (EDLC). The basic principle of the proposed MPPT control method and the proposed charging system are discussed, and then confirmed by digital computer simulation using PLECS. The simulation results reveal that the proposed MPPT controller controls the maximum power point and the proposed charging system is able to charge the battery constantly

    Piecewise linear approximations of the standard normal first order loss function

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    The first order loss function and its complementary function are extensively used in practical settings. When the random variable of interest is normally distributed, the first order loss function can be easily expressed in terms of the standard normal cumulative distribution and probability density function. However, the standard normal cumulative distribution does not admit a closed form solution and cannot be easily linearised. Several works in the literature discuss approximations for either the standard normal cumulative distribution or the first order loss function and their inverse. However, a comprehensive study on piecewise linear upper and lower bounds for the first order loss function is still missing. In this work, we initially summarise a number of distribution independent results for the first order loss function and its complementary function. We then extend this discussion by focusing first on random variable featuring a symmetric distribution, and then on normally distributed random variables. For the latter, we develop effective piecewise linear upper and lower bounds that can be immediately embedded in MILP models. These linearisations rely on constant parameters that are independent of the mean and standard deviation of the normal distribution of interest. We finally discuss how to compute optimal linearisation parameters that minimise the maximum approximation error.Comment: 22 pages, 7 figures, working draf

    Red wine and components flavonoids inhibit UGT2B17 in vitro

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    Background The metabolism and excretion of the anabolic steroid testosterone occurs by glucuronidation to the conjugate testosterone glucuronide which is then excreted in urine. Alterations in UGT glucuronidation enzyme activity could alter the rate of testosterone excretion and thus its bioavailability. The aim of this study is to investigate if red wine, a common dietary substance, has an inhibitory effect on UGT2B17. Methods Testosterone glucuronidation was assayed using human UGT2B17 supersomes with quantification of unglucuronidated testosterone over time using HPLC with DAD detection. The selected red wine was analysed using HPLC and the inhibitory effects of the wine and phenolic components were tested independently in a screening assay. Further analyses were conducted for the strongest inhibitors at physiologically relevant concentrations. Control experiments were conducted to determine the effects of the ethanol on UGT2B17. Results Over the concentration range of 2 to 8% the red wine sample inhibited the glucuronidation of testosterone by up to 70% over 2 hours. The ethanol content had no significant effect. Three red wine phenolics, identified by HLPC analyses, also inhibited the enzyme by varying amounts in the order of quercetin (72%), caffeic acid (22%) and gallic acid (9%); using a ratio of phenolic:testosterone of 1:2.5. In contrast p-coumaric acid and chlorogenic acid had no effect on the UGT2B17. The most active phenolic was selected for a detailed study at physiologically relevant concentrations, and quercetin maintained inhibitory activity of 20% at 2 M despite a ten-fold excess of testosterone. Conclusion This study reports that in an in vitro supersome-based assay, the key steroid-metabolising enzyme UGT2B17 is inhibited by a number of phenolic dietary substances and therefore may reduce the rate of testosterone glucuronidation in vivo. These results highlight the potential interactions of a number of common dietary compounds on testosterone metabolism. Considering the variety of foodstuffs that contain flavonoids, it is feasible that diet can elevate levels of circulating testosterone through reduction in urinary excretion. These results warrant further investigation and extension to a human trial to delineate the healt

    Mechanistic investigations of the asymmetric hydrosilylation of ketimines with trichlorosilane reveals a dual activation model and an organocatalyst with enhanced efficiency.

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    Structural probes used to help elucidate mechanistic information of the organocatalyzed asymmetric ketimine hydrosilylation have revealed a new catalyst with unprecedented catalytic activity, maintaining adequate performance at 0.01 mol% loading. A new 'dual activation' model has been proposed that relies on the presence of both a Lewis basic and Brønsted acidic site within the catalyst architecture

    Skeletal Diversification via Heteroatom Linkage Control: Preparation of Bicyclic and Spirocyclic Scaffolds from NSubstituted Homopropargyl Alcohols

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    The discovery and application of a new branching pathway synthesis strategy that rapidly produces skeletally diverse scaffolds is described. Two different scaffold types, one a bicyclic iodo-vinylidene tertiary amine/tertiary alcohol and the other, a spirocyclic 3-furanone, are each obtained using a two-step sequence featuring a common first step. Both scaffold types lead to intermediates that can be orthogonally diversified using the same final components. One of the scaffold types was obtained in sufficiently high yield that it was immediately used to produce a 97-compound library

    Phosphoprotein Associated with Glycosphingolipid-Enriched Microdomains Differentially Modulates Src Kinase Activity in Brain Maturation

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    Src family kinases (SFK) control multiple processes during brain development and function. We show here that the phosphoprotein associated with glycosphigolipid-enriched microdomains (PAG)/Csk binding protein (Cbp) modulates SFK activity in the brain. The timing and localization of PAG expression overlap with Fyn and Src, both of which we find associated to PAG. We demonstrate in newborn (P1) mice that PAG negatively regulates Src family kinases (SFK). P1 Pag1-/- mouse brains show decreased recruitment of Csk into lipid rafts, reduced phosphorylation of the inhibitory tyrosines within SFKs, and an increase in SFK activity of >/ = 50%. While in brain of P1 mice, PAG and Csk are highly and ubiquitously expressed, little Csk is found in adult brain suggesting altered modes of SFK regulation. In adult brain Pag1-deficiency has no effect upon Csk-distribution or inhibitory tyrosine phosphorylation, but kinase activity is now reduced (−20–30%), pointing to the development of a compensatory mechanism that may involve PSD93. The distribution of the Csk-homologous kinase CHK is not altered. Importantly, since the activities of Fyn and Src are decreased in adult Pag1-/- mice, thus presenting the reversed phenotype of P1, this provides the first in vivo evidence for a Csk-independent positive regulatory function for PAG in the brain
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