An Empirical Assessment of the Business Value Derived from Implementing Mobile Technology: A Case Study of Two Organizations

Mobile technologies are argued to offer unprecedented opportunities for organizations and individuals. In order for organizations to be persuaded that investment in mobile technologies is not only worthwhile, but also important to the achievement of corporate goals and objectives, then it is important to evaluate the potential of mobile technology so that the derivation of business value and the related risks involved in implementing mobile devices and services in an organization can be understood. This paper aims at understanding the organizational value that could be derived from investments in mobile technology. We present two in-depth case studies of mobile technology implementation in health care organizations. These studies show that deriving business value from the adoption and implementation of mobile devices does not seem at all certain, but is contingent upon clear business objectives and a willingness to make business changes to embrace the transformation to core business processes which are driven by the mobile technologies

Panel of multi-pathway analysis of 112 crude drugs/herbs.

<p>Heatmap of activity levels of 112 crude drugs/herbs across 10 reporters. Activity levels were indicated by Z-scores calculated from the relative transcriptional activities of individual crude drugs/herbs across different reporters, and by colors presented at the top of the figure. The crude drugs/herbs belonging to three traditional conceptions (heat-clearing and dampness-drying herbs, the acrid and warm exterior-resolving herbs, and the acrid and cool exterior-resolving herbs) are shown in green, red, and blue, respectively. Five major groupings are shown as the lines on the tree of crude drugs/herbs, and the enriched major groupings of three traditional conceptions are shown in green, red, and blue, respectively. **<i>P</i> <0.01 and *<i>P <0</i>.<i>05</i> by chi-square test.</p

Schematic outline of the multi-pathway analysis using 112 extracts of crude drugs/herbs.

<p>A549 cells were co-transfected with the reporter plasmids containing the transcription factor-binding site upstream of the luciferase gene with the <i>Renilla</i> luciferase gene. After the addition of the extract of crude drugs/herbs at 100 μg/ml, the cell lysates were subjected to dual-luciferase assay. The luciferase activity of each crude drug/herb was normalized to that of the vehicle control. The result of CREB reporter was shown as an example. Data are mean of two independent experiments. The hierarchical clustering and heatmap were performed using the R statistical package.</p

The different effects on each pathway by experiment-based classification.

<p>(A) Relative luciferase activity by each crude drug/herb was normalized to that of the vehicle control. The averages of relative luciferase activity of two major groupings containing exterior-resolving herbs (n = 50, filled bars) and others (n = 62, open bars) are shown. Data are the means ± S.D. of each grouping. *<i>p</i> <0.01 by two-way ANOVA followed by the Bonferroni <i>post-hoc</i> test compared with exterior-resolving medicines and others. (B) The averages of relative luciferase activity of each major groupings containing the acrid and warm exterior-resolving herbs (n = 24, filled bars) and the acrid and cool exterior-resolving herbs (n = 26, shadow bars) are shown. *<i>p</i> <0.01 by two-way ANOVA followed by the Bonferroni <i>post-hoc</i> test compared with warm and cool exterior-resolving medicines. Other conditions are similar to Fig 3A. (C) A549 cells were treated with vehicle (open bars), Perilla Herb (filled bars) or Bupleurum Root (shadow bars) for 48 h. NR4A1 (left panel) or HSP90B1 (right panel) was quantified by real-time RT-PCR. Relative mRNA expression was normalized to the value of each mRNA in vehicle-treated cells. Data are shown as the mean ± SD of three independent experiments.</p

Campechic Acids A and B: Anti-invasive Polyether Polyketides from a Soil-Derived <i>Streptomyces</i>

Campechic acids A (<b>1</b>) and B (<b>2</b>), two new polyketides, were isolated from the culture extract of <i>Streptomyces</i> sp., and their structures were determined by NMR and MS spectroscopic analysis. Campechic acids are polyether-polyketides functionalized by two tetrahydrofuran rings, an enolized 1,3-diketone, and multiple methyl substitutions. Absolute configuration of nine stereogenic centers in <b>1</b>, except for four chiral centers in the cyclic ether moieties, was determined by the ¹H NMR anisotropy method in combination with chemical degradation. Campechic acids exhibited potent inhibitory effects on tumor cell invasion with IC₅₀ values in the nanomolar to submicromolar range

Antiausterity Agents from <i>Uvaria dac</i> and Their Preferential Cytotoxic Activity against Human Pancreatic Cancer Cell Lines in a Nutrient-Deprived Condition

Human pancreatic cancer cell lines are known for their inherent tolerance to nutrition starvation, which enables them to survive under a hypovascular (austerity) tumor microenvironment. The search for agents that preferentially retard the survival of cancer cells under low nutrition conditions (antiausterity agent) is a novel approach to anticancer drug discovery. In this study, it was found that a dichloromethane extract of the stem of <i>Uvaria dac</i> preferentially inhibited PANC-1 human pancreatic cancer cells survival under nutrition-deprived conditions at a concentration of 10 μg/mL. Workup of this bioactive extract led to the discovery of (+)-grandifloracin (<b>8</b>) as a potent antiausterity agent as evaluated in a panel of four human pancreatic cancer cell lines, PANC-1 (PC₅₀, 14.5 μM), PSN-1 (PC₅₀, 32.6 μM), MIA PaCa-2 (PC₅₀, 17.5 μM), and KLM-1 (32.7 μM). (+)-Grandifloracin (<b>8</b>) has been isolated from a natural source for the first time. Its absolute stereochemistry was established by single-crystal X-ray crystallography and circular dichroism spectroscopic analysis. In addition to this, seven other new highly oxygenated cyclohexene derivatives, named uvaridacanes A (<b>1</b>) and B (<b>2</b>), uvaridacols A–D (<b>3</b>, <b>4</b>,<b> 6</b>, <b>7</b>), and uvaridapoxide A (<b>5</b>), were also isolated and structurally characterized

Structure, Synthesis, and Biological Activity of a C‑20 Bisacetylenic Alcohol from a Marine Sponge <i>Callyspongia</i> sp.

An optically inactive C-20 bisacetylenic alcohol, (4<i>E</i>,16<i>E</i>)-icosa-4,16-diene-1,19-diyne-3,18-diol, was isolated from a marine sponge <i>Callyspongia</i> sp. as a result of screening of antilymphangiogenic agents from marine invertebrates. An optical resolution using chiral-phase HPLC gave each enantiomer, (−)-<b>1</b> and (+)-<b>2</b>. Because the natural and synthetic enantiomers <b>1</b> and <b>2</b> showed different biological properties, we investigated the structure–activity relationships of bisacetylenic alcohols using 11 synthetic derivatives, and it is clarified that the essential structural unit for antiproliferative activity is the “1-yn-3-ol” on both termini and that there is a minimum chain length that connects the “1-yn-3-ol” moieties

Nonthmicin, a Polyether Polyketide Bearing a Halogen-Modified Tetronate with Neuroprotective and Antiinvasive Activity from <i>Actinomadura</i> sp.

Nonthmicin (<b>1</b>), a new polyether polyketide bearing a chlorinated tetronic acid, was isolated from the culture extract of a soil-derived <i>Actinomadura</i> strain. The structure of <b>1</b> was elucidated by interpretation of NMR and MS spectroscopic data, and the absolute configuration of <b>1</b> was proposed on the basis of the crystal structure of its dechloro congener ecteinamycin (<b>2</b>) also isolated from the same strain. Tetronic acids modified by halogenation have never been reported from natural products. Compounds <b>1</b> and <b>2</b> were found to have neuroprotective activity and antimetastatic properties at submicromolar concentrations in addition to antibacterial activity