DataSheet_1_Better oral hygiene is associated with a reduced risk of osteoporotic fracture: a nationwide cohort study.docx

BackgroundThe aim of this study was to examine the longitudinal association between oral health parameters and osteoporotic fracture.MethodsThe study included participants who received oral health screening by dentists from the National Health Screening cohort database of Korea between 2003 and 2006. The primary outcome was osteoporotic fracture occurrence, which was defined using specific international classification of diseases-10 codes; vertebral fracture (S22.0, S22.1, S32.0, S32.7, T08, M48.4, M48.5, and M49.5), hip fracture (S72.0 and S72.1), distal radius fracture (S52.5 and S52.6), and humerus fracture (S42.2 and S42.3). The presence of periodontitis and various oral health examination findings, such as missing teeth, caries, frequency of tooth brushing, and dental scaling, were analyzed using a Cox proportional hazard model to assess their association with osteoporotic fracture occurrence.ResultsThe analysis included a total of 194,192 participants, among whom 16,683 (8.59%) developed osteoporotic fracture during a median follow-up of 10.3 years. Poor oral health status, including periodontitis (adjusted hazard ratio [aHR]: 1.09, 95% confidence interval [CI]: 1.01–1.18, p = 0.039), a higher number of missing teeth (≥15; aHR: 1.59, 95% CI: 1.45–1.75, p ConclusionThe study found that poor oral health, such as periodontitis, missing teeth, and dental caries, was associated with an increased risk of osteoporotic fracture. Conversely, good oral hygiene behaviors like frequent teeth brushing and dental scaling within 1 year were associated with a reduced risk. Further research is needed to confirm this association.</p

2D Perovskite Nanosheets with Thermally-Stable High‑κ Response: A New Platform for High-Temperature Capacitors

We investigated high-temperature dielectric responses of high-κ perovskite nanosheet (Ca₂Nb₃O₁₀), an important material platform for postgraphene technology and ultrascale electronic devices. Through <i>in situ</i> characterizations using conducting atomic force microscopy, we found a robust high-temperature property of Ca₂Nb₃O₁₀ nanosheet even in a monolayer form (∼2 nm). Furthermore, layer-by-layer assembled nanocapacitors retained both size-free high-ε_r characteristic (∼200) and high insulation resistance (∼1 × 10^–7 A/cm²) at high temperatures up to 250 °C. The simultaneous improvement of ε_r and thermal stability in high-κ nanodielectrics is of critical technological importance, and perovskite nanosheet has great potential for a rational design and construction of high-temperature capacitors

Table_1_Better oral hygiene is associated with a reduced risk of osteoporotic fracture: a nationwide cohort study.docx

BackgroundThe aim of this study was to examine the longitudinal association between oral health parameters and osteoporotic fracture.MethodsThe study included participants who received oral health screening by dentists from the National Health Screening cohort database of Korea between 2003 and 2006. The primary outcome was osteoporotic fracture occurrence, which was defined using specific international classification of diseases-10 codes; vertebral fracture (S22.0, S22.1, S32.0, S32.7, T08, M48.4, M48.5, and M49.5), hip fracture (S72.0 and S72.1), distal radius fracture (S52.5 and S52.6), and humerus fracture (S42.2 and S42.3). The presence of periodontitis and various oral health examination findings, such as missing teeth, caries, frequency of tooth brushing, and dental scaling, were analyzed using a Cox proportional hazard model to assess their association with osteoporotic fracture occurrence.ResultsThe analysis included a total of 194,192 participants, among whom 16,683 (8.59%) developed osteoporotic fracture during a median follow-up of 10.3 years. Poor oral health status, including periodontitis (adjusted hazard ratio [aHR]: 1.09, 95% confidence interval [CI]: 1.01–1.18, p = 0.039), a higher number of missing teeth (≥15; aHR: 1.59, 95% CI: 1.45–1.75, p ConclusionThe study found that poor oral health, such as periodontitis, missing teeth, and dental caries, was associated with an increased risk of osteoporotic fracture. Conversely, good oral hygiene behaviors like frequent teeth brushing and dental scaling within 1 year were associated with a reduced risk. Further research is needed to confirm this association.</p

Identifying the Location of a Single Protein along the DNA Strand Using Solid-State Nanopores

Solid-state nanopore has been widely studied as an effective tool to detect and analyze small biomolecules, such as DNA, RNA, and proteins, at a single molecule level. In this study, we demonstrate a rapid identification of the location of zinc finger protein (ZFP), which is bound to a specific locus along the length of a double-stranded DNA (dsDNA) to a single protein resolution using a low noise solid-state nanopore. When ZFP labeled DNAs were driven through a nanopore by an externally applied electric field, characteristic ionic current signals arising from the passage of the DNA/ZFP complex and bare DNA were detected, which enabled us to identify the locations of ZFP binding site. We examined two DNAs with ZFP binding sites at different positions and found that the location of the additional current drop derived from the DNA/ZFP complex is well-matched with a theoretical one along the length of the DNA molecule. These results suggest that the protein binding site on DNA can be mapped or that genetic information can be read at a single molecule level using solid-state nanopores

MOESM1 of Role of ethambutol and rifampicin in the treatment of Mycobacterium avium complex pulmonary disease

Additional file 1: Table S1. Detailed dosage information about the antimycobacterial agents used in the treatment of Mycobacterium avium complex lung disease. Table S2. Detailed description of 5 patients who developed clarithromycin resistance during treatment failure. Table S3. Patient characteristics according to the use of ethambutol and rifampicin

Characteristics of remifentanil infusion rate groups.

Characteristics of remifentanil infusion rate groups.</p

Changes in pain scores and analgesic consumption for 48 hours after robotic thyroidectomy.

A: Postoperative pain is quantified by 11-point (0–11) numeric rating scale. Data are expressed as mean ± SD (symbol and error bar). B: The number of patients requiring analgesic for each hour is divided by the total number of patients. Data are expressed as incidence (%).</p

Basic characteristics (n = 635).

Basic characteristics (n = 635).</p

Changes in pain scores, analgesic consumption, and incidence of treatment-requiring pain in two remifentanil groups for 48 hours after robotic thyroidectomy.

Postoperative pain was quantified by 11-point (0–11) numeric rating scale. Treatment-requiring pain was defined when numeric rating scale of the pain is greater than 4. A, B and C: Two remifentanil categories are not easily distinguishable in terms of pain scores, analgesic use and treatment-requiring pain incidence. D: Time dependent Cox proportional hazards regression analysis identified that the risk of treatment-requiring pain was 1.3 times higher in the high-dose remifentanil group than in the low-dose group after adjusting for analgesic consumption and its interaction with time.</p

Predictors of postoperative treatment-requiring pain in robotic thyroid surgery patients anesthetized with total intravenous anesthesia.

Predictors of postoperative treatment-requiring pain in robotic thyroid surgery patients anesthetized with total intravenous anesthesia.</p