Clinical outcomes.

<p>Clinical outcomes.</p

Capecitabine and cisplatin (XP) combination systemic chemotherapy in heavily pre-treated HER2 negative metastatic breast cancer - Fig 3

<p>Progression free survival according to prior numbers of systemic chemotherapy in total patient population (A) and in hormone receptor positive patients (B).</p

Chemotherapy toxicities.

<p>Chemotherapy toxicities.</p

Progression free survival according to hormone receptor status.

<p>Progression free survival according to hormone receptor status.</p

Capecitabine and cisplatin (XP) combination systemic chemotherapy in heavily pre-treated HER2 negative metastatic breast cancer - Fig 1

<p>The median progression free survival (A) and overall survival (B) in total patient population.</p

Characteristics of patient population.

<p>Characteristics of patient population.</p

Univariate and multivariate analysis of progression free survival in HR positive patients.

<p>Univariate and multivariate analysis of progression free survival in HR positive patients.</p

Previous studies of XP regimen in metastatic breast cancer patients previously treated with anthracycline and taxane.

<p>Previous studies of XP regimen in metastatic breast cancer patients previously treated with anthracycline and taxane.</p

Electroceutical Residue-Free Graphene Device for Dopamine Monitoring and Neural Stimulation

The simultaneous neural signal monitoring and stimulation can allow accurate neurotransmitter regulation for patients in various degrees of neural degeneration disorders. Here, we developed a residue-free graphene device as an effective electrical neural interface for dopamine sensing and secretion. We demonstrated the ultrasensitive dopamine sensing of residue-free graphene devices cultured with PC12 cells and the on-demand functional electrical stimulation for electroceutical applications. The doping effect of graphene by the released dopamine from living cells was confirmed from the electrical current change. The dopamine release could be also quantitatively analyzed by ELISA. Then, Ca2+ ion-dependent dopamine release was optically observed by fluorescence microscopy during the stimulation. Taken together, this study confirms the feasibility of graphene surface as a neural interface for electroceutical applications to various central nerve system disorders

Disordered Mixture of Self-Assembled Molecular Functional Groups on Heterointerfaces with p‑Si Leads to Multiple Key Generation in Physical Unclonable Functions

Physical unclonable function (PUF) security devices based on hardware are becoming an effective strategy to overcome the dependency of the internet cloud and software-based hacking vulnerabilities. On the other hand, existing Si-based artificial security devices have several issues, including the absence of a method for multiple key generation, complex and expensive fabrication processes, and easy prediction compared to devices retaining natural randomness. Herein, to generate unique and unpredictable multiple security keys, this paper proposes novel PUF devices consisting of a disordered random mixture of two self-assembled monolayers (SAMs) formed onto p-type Si. The proposed PUF devices exhibited multikeys at different voltage biasing, including 0 V, through the arbitrary dipole effect. As a result, multiple unpredictable hardware security keys were generated from one device using a simple solution-coating process. The PUF security device based on the mixture of materials with different dipoles developed in this study can provide valuable insights for implementing various PUF devices in the future