Novel approach to measure the leptonic eta(')->mu+mu- decays via charmed meson decays

In this article, we propose a novel approach to measure the branching ratios of the leptonic eta(')-> mu+mu- decays by using charmed meson decays, namely, D+(s)->pi+ eta(')(->mu+mu-) and D0->K-pi+eta(')(->mu+mu-). We advocate that the data available at LHCb can already yield a new measurement of Br(eta->mu+mu-) with accuracy competitive with the current world average. We also estimate that using the data collected by LHCb between 2015 and 2018 in proton-proton collisions at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 5.0/fb, the relative uncertainties to this branching ratio can be reduced down to ~10%. We also show that the first observation of Br(eta'->mu+mu-) may be possible with the Upgrade of the LHCb experiment.Comment: 12 pages, 3 figure

Redundancy and compensation in axon guidance: genetic analysis of the Drosophila Ptp10D/Ptp4E receptor tyrosine phosphatase subfamily

Background: Drosophila has six receptor protein tyrosine phosphatases (RPTPs), five of which are expressed primarily in neurons. Mutations in all five affect axon guidance, either alone or in combination. Highly penetrant CNS and motor axon guidance alterations are usually observed only when specific combinations of two or more RPTPs are removed. Here, we examine the sixth RPTP, Ptp4E, which is broadly expressed. Results: Ptp4E and Ptp10D are closely related Type III RPTPs. Non-drosophilid insect species have only one Type III RPTP, which is closest to Ptp10D. We found that Ptp4E mutants are viable and fertile. We then examined Ptp4E Ptp10D double mutants. These die before the larval stage, and have a mild CNS phenotype in which the outer longitudinal 1D4 bundle is frayed. Ptp10D Ptp69D double mutants have a strong CNS phenotype in which 1D4 axons abnormally cross the midline and the outer and middle longitudinal bundles are fused to the inner bundle. To examine if Ptp4E also exhibits synthetic phenotypes in combination with Ptp69D, we made Ptp4E Ptp69D double mutants and Ptp4E Ptp10D Ptp69D triple mutants. No phenotype was observed in the double mutant. The triple mutant phenotype differs from the Ptp10D Ptp69D phenotype in two ways. First, the longitudinal tracts appear more normal than in the double mutant; two or three bundles are observed, although they are disorganized and fused. Second, axons labelled by the SemaIIB-tMyc marker often cross in the wrong commissure. We also examined motor axon guidance, and found that no phenotypes are observed in any Ptp4E double mutant combination. However, triple mutants in which Ptp4E Ptp10D was combined with Ptp69D or Ptp52F exhibited stronger phenotypes than the corresponding Ptp10D double mutants. Conclusions: Type III RPTPs are required for viability in Drosophila, since Ptp4E Ptp10D double mutants die before the larval stage. Unlike Ptp10D, Ptp4E appears to be a relatively minor player in the control of axon guidance. Strong phenotypes are only observed in triple mutants in which both Type III RPTPs are eliminated together with Ptp69D or Ptp52F. Our results allow us to construct a complete genetic interaction matrix for all six of the RPTPs

Multilingual Schema Matching for Wikipedia Infoboxes

Recent research has taken advantage of Wikipedia's multilingualism as a resource for cross-language information retrieval and machine translation, as well as proposed techniques for enriching its cross-language structure. The availability of documents in multiple languages also opens up new opportunities for querying structured Wikipedia content, and in particular, to enable answers that straddle different languages. As a step towards supporting such queries, in this paper, we propose a method for identifying mappings between attributes from infoboxes that come from pages in different languages. Our approach finds mappings in a completely automated fashion. Because it does not require training data, it is scalable: not only can it be used to find mappings between many language pairs, but it is also effective for languages that are under-represented and lack sufficient training samples. Another important benefit of our approach is that it does not depend on syntactic similarity between attribute names, and thus, it can be applied to language pairs that have distinct morphologies. We have performed an extensive experimental evaluation using a corpus consisting of pages in Portuguese, Vietnamese, and English. The results show that not only does our approach obtain high precision and recall, but it also outperforms state-of-the-art techniques. We also present a case study which demonstrates that the multilingual mappings we derive lead to substantial improvements in answer quality and coverage for structured queries over Wikipedia content.Comment: VLDB201

Early prediction of triple negative breast cancer response to cisplatin treatment using diffusion-weighted MRI and 18F-FDG-PET

学位記番号：医博甲1707

Quantifying the effects of modelling choices on hospital efficiency measures: A meta-regression analysis

It has often been argued that the results of efficiency analyses in health care are influenced by the modelling choices made by the researchers involved. In this paper we use meta-regression analysis in an attempt to quantify the degree to which modelling factors influence efficiency estimates. The data set is derived from 253 estimated models reported in 95 empirical analyses of hospital efficiency in the 22-year period from 1987 to 2008. A meta-regression model is used to investigate the degree to which differences in mean efficiency estimates can be explained by factors such as: sample size; dimension (number of variables); parametric versus non-parametric method; returns to scale (RTS) assumptions; functional form; error distributional form; input versus output orientation; cost versus technical efficiency measure; and cross-sectional versus panel data. Sample size, dimension and RTS are found to have statistically significant effects at the 1% level. Sample size has a negative (and diminishing) effect on efficiency; dimension has a positive (and diminishing) effect; while the imposition of constant returns to scale has a negative effect. These results can be used in improving the policy relevance of the empirical results produced by hospital efficiency studies.

Single pion contribution to the hyperfine splitting in muonic hydrogen

A detailed discussion of the long-range one-pion exchange (Yukawa potential) contribution to the 2S hyperfine splitting in muonic hydrogen which had, until recently, been disregarded is presented. We evaluate the relevant vertex amplitudes, in particular $\pi^0\mu^+\mu^-$, combining low energy chiral expansions together with experimental data on $\pi^0$ and $\eta$ decays into two leptons. A value of $\Delta{E}^\pi_{HFS}= -(0.09 \pm 0.06)\ \mu\rm{eV}$ is obtained for this contribution.Comment: v2: Expanded and completed versio