5 research outputs found

    Copper-Catalyzed Intermolecular Cyanotrifluoromethylation of Alkenes

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    A novel and highly practical reaction for the copper-catalyzed intermolecular cyanotrifluoromethylation of alkenes is presented here. This methodology provides a general and straightforward way to synthesize a variety of useful CF<sub>3</sub>-containing nitriles, which can be used for further preparation of pharmaceutically and agrochemically important compounds in synthetic organic chemistry

    Copper-Catalyzed Three-Component Cyano­trifluoro­methyla­tion/Azido­trifluoro­methyla­tion and Carbo­cycli­zation of 1,6-Enynes

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    A novel three-component strategy for the cyano­trifluoro­methyla­tion/azido­trifluoro­methyla­tion and carbocyclization of 1,6-enynes is developed. The reaction proceeds smoothly under a moderate temperature by using a copper catalyst, which provides a rapid and concise access to addition–carbocyclization products. Furthermore, the products obtained can be useful building blocks in discoveries of lead compounds and other biologically active CF<sub>3</sub>-containing heterocycles

    Copper-Catalyzed Intermolecular Cyanotrifluoromethylation of Alkenes

    No full text
    A novel and highly practical reaction for the copper-catalyzed intermolecular cyanotrifluoromethylation of alkenes is presented here. This methodology provides a general and straightforward way to synthesize a variety of useful CF<sub>3</sub>-containing nitriles, which can be used for further preparation of pharmaceutically and agrochemically important compounds in synthetic organic chemistry

    Silver-Catalyzed Oxidative Cyclization of Propargylamide-Substituted Indoles: Synthesis of Phosphorated Indoloazepinones Derivatives

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    A silver-catalyzed oxidative cyclization of 2- or 3-propargylamide-substituted indoles to synthesize phosphorated indoloaze­pinone derivatives is described. This reaction displays a difunctionalizalion of alkynes with diphenyl­phosphine oxides to construct a seven-membered ring through a radical cyclization process. The indolo­azepinones derivatives are common structural motifs found in many natural products and pharmaceuticals

    AgSCF<sub>3</sub>‑Mediated Trifluoromethylthiolation/Radical Cascade Cyclization of 1,6-Enynes

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    A AgSCF<sub>3</sub>-mediated radical cascade cyclization/trifluoromethylthiolation of 1,6-enynes triggered by a C–C triple bond is developed. This protocol also provides another opportunity to construct a valuable trifluoromethylthio-substituted polycyclic fluorene system through the formations of one C–SCF<sub>3</sub> bond and two C–C bonds in a single step
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