5 research outputs found
Copper-Catalyzed Intermolecular Cyanotrifluoromethylation of Alkenes
A novel and highly
practical reaction for the copper-catalyzed
intermolecular cyanotrifluoromethylation of alkenes is presented here.
This methodology provides a general and straightforward way to synthesize
a variety of useful CF<sub>3</sub>-containing nitriles, which can
be used for further preparation of pharmaceutically and agrochemically
important compounds in synthetic organic chemistry
Copper-Catalyzed Three-Component CyanoÂtrifluoroÂmethylaÂtion/AzidoÂtrifluoroÂmethylaÂtion and CarboÂcycliÂzation of 1,6-Enynes
A novel three-component
strategy for the cyanoÂtrifluoroÂmethylaÂtion/azidoÂtrifluoroÂmethylaÂtion
and carbocyclization of 1,6-enynes is developed. The reaction proceeds
smoothly under a moderate temperature by using a copper catalyst,
which provides a rapid and concise access to addition–carbocyclization
products. Furthermore, the products obtained can be useful building
blocks in discoveries of lead compounds and other biologically active
CF<sub>3</sub>-containing heterocycles
Copper-Catalyzed Intermolecular Cyanotrifluoromethylation of Alkenes
A novel and highly
practical reaction for the copper-catalyzed
intermolecular cyanotrifluoromethylation of alkenes is presented here.
This methodology provides a general and straightforward way to synthesize
a variety of useful CF<sub>3</sub>-containing nitriles, which can
be used for further preparation of pharmaceutically and agrochemically
important compounds in synthetic organic chemistry
Silver-Catalyzed Oxidative Cyclization of Propargylamide-Substituted Indoles: Synthesis of Phosphorated Indoloazepinones Derivatives
A silver-catalyzed
oxidative cyclization of 2- or 3-propargylamide-substituted
indoles to synthesize phosphorated indoloazeÂpinone derivatives
is described. This reaction displays a difunctionalizalion of alkynes
with diphenylÂphosphine oxides to construct a seven-membered
ring through a radical cyclization process. The indoloÂazepinones
derivatives are common structural motifs found in many natural products
and pharmaceuticals
AgSCF<sub>3</sub>‑Mediated Trifluoromethylthiolation/Radical Cascade Cyclization of 1,6-Enynes
A AgSCF<sub>3</sub>-mediated radical cascade cyclization/trifluoromethylthiolation
of 1,6-enynes triggered by a C–C triple bond is developed.
This protocol also provides another opportunity to construct a valuable
trifluoromethylthio-substituted polycyclic fluorene system through
the formations of one C–SCF<sub>3</sub> bond and two C–C
bonds in a single step