New Cytotoxic Monotetrahydrofuran Annonaceous Acetogenins from <i>Annona </i><i>m</i><i>uricata</i>

Three new monotetrahydrofuran annonaceous acetogenins, muricin H (1), muricin I (2), and cis-annomontacin (3), along with five known acetogenins, annonacin, annonacinone, annomontacin, murisolin, and xylomaticin, were isolated from the seeds of Annona muricata. Additionally, two new monotetrahydrofuran annonaceous acetogenins, cis-corossolone (4) and annocatalin (5), together with four known ones, annonacin, annonacinone, solamin, and corossolone, were isolated from the leaves of this species. The structures of all new isolates were elucidated and characterized by spectral and chemical methods. These new acetogenins exhibited significant activity in in vitro cytotoxic assays against two human hepatoma cell lines, Hep G2 and 2,2,15. Compound 5 showed a high selectivity toward the Hep 2,2,15 cell line

The Induction of Vascular Endothelial Growth Factor by Ultrafine Carbon Black Contributes to the Increase of Alveolar-Capillary Permeability-3

<p><b>Copyright information:</b></p><p>Taken from "The Induction of Vascular Endothelial Growth Factor by Ultrafine Carbon Black Contributes to the Increase of Alveolar-Capillary Permeability"</p><p>Environmental Health Perspectives 2005;113(4):454-460.</p><p>Published online 4 Jan 2005</p><p>PMCID:PMC1278486.</p><p>This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI.</p

The Induction of Vascular Endothelial Growth Factor by Ultrafine Carbon Black Contributes to the Increase of Alveolar-Capillary Permeability-0

<p><b>Copyright information:</b></p><p>Taken from "The Induction of Vascular Endothelial Growth Factor by Ultrafine Carbon Black Contributes to the Increase of Alveolar-Capillary Permeability"</p><p>Environmental Health Perspectives 2005;113(4):454-460.</p><p>Published online 4 Jan 2005</p><p>PMCID:PMC1278486.</p><p>This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI.</p

The Induction of Vascular Endothelial Growth Factor by Ultrafine Carbon Black Contributes to the Increase of Alveolar-Capillary Permeability-1

<p><b>Copyright information:</b></p><p>Taken from "The Induction of Vascular Endothelial Growth Factor by Ultrafine Carbon Black Contributes to the Increase of Alveolar-Capillary Permeability"</p><p>Environmental Health Perspectives 2005;113(4):454-460.</p><p>Published online 4 Jan 2005</p><p>PMCID:PMC1278486.</p><p>This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI.</p

The Induction of Vascular Endothelial Growth Factor by Ultrafine Carbon Black Contributes to the Increase of Alveolar-Capillary Permeability-4

<p><b>Copyright information:</b></p><p>Taken from "The Induction of Vascular Endothelial Growth Factor by Ultrafine Carbon Black Contributes to the Increase of Alveolar-Capillary Permeability"</p><p>Environmental Health Perspectives 2005;113(4):454-460.</p><p>Published online 4 Jan 2005</p><p>PMCID:PMC1278486.</p><p>This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI.</p

The Induction of Vascular Endothelial Growth Factor by Ultrafine Carbon Black Contributes to the Increase of Alveolar-Capillary Permeability-5

<p><b>Copyright information:</b></p><p>Taken from "The Induction of Vascular Endothelial Growth Factor by Ultrafine Carbon Black Contributes to the Increase of Alveolar-Capillary Permeability"</p><p>Environmental Health Perspectives 2005;113(4):454-460.</p><p>Published online 4 Jan 2005</p><p>PMCID:PMC1278486.</p><p>This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI.</p

The Induction of Vascular Endothelial Growth Factor by Ultrafine Carbon Black Contributes to the Increase of Alveolar-Capillary Permeability-2

<p><b>Copyright information:</b></p><p>Taken from "The Induction of Vascular Endothelial Growth Factor by Ultrafine Carbon Black Contributes to the Increase of Alveolar-Capillary Permeability"</p><p>Environmental Health Perspectives 2005;113(4):454-460.</p><p>Published online 4 Jan 2005</p><p>PMCID:PMC1278486.</p><p>This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI.</p