Association of SMAD7 rs12953717 Polymorphism with Cancer: A Meta-Analysis

<div><p>Background</p><p>Accumulating evidence has suggested that Mothers against decapentaplegic homolog 7 (SMAD7) rs12953717 polymorphism might be related to cancer risk. However, epidemiologic findings have been inconsistent. We therefore performed a meta-analysis to clarify the association between the SMAD7 rs12953717 polymorphism and cancer risk.</p> <p>Methods</p><p>A comprehensive search was conducted to identify all eligible studies of SMAD7 rs12953717 polymorphism and cancer risk. We used odds ratios (ORs) to assess the strength of the association, and 95% confidence intervals (CIs) to give a sense of the precision of the estimate. Heterogeneity, publication bias, and sensitivity analysis were also explored.</p> <p>Results</p><p>A total of 14 case-control studies, including 16928 cases and 14781 controls, were included in the present meta-analysis. The overall results showed that the variant genotypes were associated with a significantly increased risk of all cancer types (homozygote comparison, OR = 1.23, 95%CI = 1.10–1.38, P<0.01; heterozygote comparison, OR = 1.12, 95%CI = 1.02–1.22, P = 0.02; recessive model, OR = 1.17, 95%CI = 1.07–1.29, P<0.01; dominant model, OR = 1.15, 95%CI = 1.06–1.25, P<0.01; allelic model, OR = 1.12, 95%CI = 1.06–1.18, P<0.01). Further sensitivity analysis confirmed the significant association. In the subgroup analysis by ethnicity, SMAD7 rs12953717 polymorphism was significantly associated with cancer risk in both Caucasians and Asians. In the subgroup analysis by cancer types, SMAD7 rs12953717 polymorphism was significantly associated with colorectal cancer.</p> <p>Conclusions</p><p>Our investigations demonstrate that rs12953717 polymorphism is associated with the susceptibility of cancer. Large-scale and well-designed case-control studies are necessary to validate the risk identified in the present meta-analysis.</p> </div

China’s strictest water policy reverses water use trends and alleviates water stress

The datassets provided by with the paper entitled "China’s strictest water policy reverses water use trends and alleviates water stress". (1) The GDP_Pop folder contains population and GDP data for different provinces.     (The file names include the IDs of the different provinces, as shown in provinces_ID.xlsx). (2) The IndGDP folder contains the value added of industrial products (industrial GVA). (3) The Decompostion_analysis_data folder contains the data used for Decompostion_analysis, including     irrigated area, irrigation water intensity, industrial GVA, industrial water intensity. population, and model water intensity for different provinces. (4) provinces_ID.xlsx contains the IDs of the different provinces.</p

Meta-Analysis of SMAD7 rs12953717 Polymorphism and Cancer.

<p>SMAD7, Mothers against decapentaplegic homolog 7; OR, odds ratio; CI, confidence interval.</p

Supplementary document for Tuning spin-orbit coupling and realizing inverse persistent spin helix by an extra above-barrier radiation in a GaAs/Al0.3Ga0.7As heterostructure - 6363365.pdf

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Single Ag Nanoparticle Electro-oxidation: Potential-Dependent Current Traces and Potential-Independent Electron Transfer Kinetic

Potential-dependent current traces were first observed for the same sized nanoparticles (NPs) during the dynamic electro-oxidation process of single AgNPs. In this work, we demonstrated that the motion trajectories of NPs, coupled with electrochemical kinetics parameters, qualitatively predicted from the series of the experimentally observed current traces obtained single AgNPs collision behaviors. Based on the Poisson–Boltzmann equation for a general electrochemical reaction, a rate constant of Ag oxidation could be further estimated to be 1 × 10^–6 mol·cm^–2·s^–1 for electron transfer between AgNPs and the Au electrode by comparing the experimental results. Our method provided a meaningful attempt to test electron transfer kinetics and motion behaviors of single NPs using the high-resolution electrochemical signal

Association of Methylenetetrahydrofolate Dehydrogenase 1 Polymorphisms with Cancer: A Meta-Analysis

<div><p>Background</p><p>Studies investigating the association between single-nucleotide polymorphisms (SNPs) of the methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) and cancer risk report conflicting results. To derive a more precise estimation of the relationship between MTHFD1 polymorphisms and cancer risk, the present meta-analysis was carried out.</p><p>Methodology/Principal Findings</p><p>A comprehensive search was conducted to determine all the eligible studies about MTHFD1 polymorphisms and cancer risk. Combined odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association between the MTHFD1 polymorphisms and cancer risk. We investigated by meta-analysis the effects of 2 polymorphisms in MTHFD1: G1958A (17 studies, 12348 cases, 44132 controls) and G401A (20 studies, 8446 cases, 14020 controls). The overall results indicated no major influence of these 2 polymorphisms on cancer risk. For G1958A, a decreased cancer risk was found in acute lymphoblastic leukemia (ALL)/Asians (the dominant: OR = 0.74, 95% CI = 0.58–0.94, P = 0.01; allelic: OR = 0.80, 95% CI = 0.65–0.99, P = 0.04) and other cancers (recessive: OR = 0.80, 95% CI = 0.66–0.96, P = 0.02). For G401A, the data showed that MTHFD1 G401A polymorphism was associated with a decreased colon cancer risk under dominant model (OR = 0.89, 95% CI = 0.80–0.99, P = 0.04).</p><p>Conclusions</p><p>The results suggest that MTHFD1 G1958A polymorphism might be associated with a decreased risk of ALL and other cancers. Meanwhile, the MTHFD1 G401A might play a protective role in the development of colon cancer. Large-scale and well-designed case-control studies are necessary to validate the risk identified in the present meta-analysis.</p></div

Meta-Analysis of MTHFD1 Gene Polymorphisms and Cancer.

<p>OR, odds ratio; CI, confidence interval.</p

Competitive immunoassay for monitoring polybrominated diphenyl ethers in PM_2.5 in Shanghai

<p>In this paper, a sensitive biotin–streptavidin (BS)-ELISA was developed for determining the polybrominated diphenyl ethers in PM_2.5. For establishing this proposed BS-ELISA, we prepared the biotinylated antibody primarily. And for reducing the background interference, some influencing factors and procedures for this immunoassay were also discussed and optimised. Under the optimal conditions, the IC₅₀ = 0.53 ng/mL; IC₁₀ was 0.002 ng/mL; and the results were almost consistent with those using the gas chromatography and electron capture detection (GC-ECD). Less procedures and simpler sample preparation were required for this method compared with the GC-ECD. The results showed that the highest value of BDE-47 concentration occurred in December, which might reflect the combination of heating and industrial pollution. In our analysis, we studied the Pearson correlations between BDE-47/PM_2.5 and gaseous pollutants (such as NO₂, SO₂, CO, O₃, PM₁₀ and PM_2.5). BDE-47 showed a higher correlation with NO₂ than that with PM₁₀, PM_2.5 and SO₂, which implied that the BDE-47 emission process might be accompanied by the emission of NO₂. Moreover, during the Spring Festival, the concentration of BDE-47 in PM_2.5 decreased significantly, whereas the PM_2.5 changed little. This suggested factories and vehicles might be the major contributors to BDE-47 emissions (but not to PM_2.5).</p

Media 1: Single-shot spatially modulated Stokes polarimeter based on a GRIN lens

Originally published in Optics Letters on 01 May 2014 (ol-39-9-2656

Supplementary document for Polarization feature fusion and calculation of birefringence dynamics in complex anisotropic media - 6903525.pdf

Supplemental Documen