Bismuth Nanoparticle-Embedded Carbon Microrod for High-Rate Electrochemical Magnesium Storage

Bismuth metal is regarded as a promising magnesium storage anode material for magnesium-ion batteries due to its high theoretical volumetric capacity and a low alloying potential versus magnesium metal. However, the design of highly dispersed bismuth-based composite nanoparticles is always used to achieve efficient magnesium storage, which is adverse to the development of high-density storage. Herein, a bismuth nanoparticle-embedded carbon microrod (Bi⊂CM), which is prepared via annealing of the bismuth metal–organic framework (Bi-MOF), is developed for high-rate magnesium storage. The use of the Bi-MOF precursor synthesized at an optimized solvothermal temperature of 120 °C benefits the formation of the Bi⊂CM-120 composite with a robust structure and a high carbon content. As a result, the as-prepared Bi⊂CM-120 anode compared to pure Bi and other Bi⊂CM anodes exhibits the best rate performance of magnesium storage at various current densities from 0.05 to 3 A g–1. For example, the reversible capacity of the Bi⊂CM-120 anode at 3 A g–1 is ∼17 times higher than that of the pure Bi anode. This performance is also competitive among those of the previously reported Bi-based anodes. Importantly, the microrod structure of the Bi⊂CM-120 anode material remained upon cycling, indicative of good cycling stability

Data of RSOS-171436.R3

Data of RSOS-171436.R

Data_Sheet_1_AfCHIL, a Type IV Chalcone Isomerase, Enhances the Biosynthesis of Naringenin in Metabolic Engineering.docx

Naringenin is an essential precursor for all flavonoids, and effectively promoting naringenin production is crucial in metabolic engineering. The interaction between plant metabolic enzymes ensures metabolic flux. The effect can effectively improve the natural product synthesis of engineering microbial systems. In this study, chalcone isomerase genes in Allium fistulosum have been identified. The expression of AfCHIL is closely related to the accumulation of anthocyanins, and the expression of AfCHIL and AfCHS was highly synchronized. Yeast two-hybrid and firefly luciferase complementation imaging assay further confirmed AfCHIL physically interacted with AfCHS/AfCHI. The bioconversion experiment confirmed that AfCHIL reduced the derailment produced by AfCHS and increased the yield of naringenin. In addition, a system of biosynthesis naringenin involved in AfCHS was constructed, and these results suggested that the potential function between CHS with CHIL advanced naringenin production effectively. In conclusion, this study illustrated the function of AfCHIs in Allium fistulosum and provided new insight into improving the synthesis efficiency of naringenin.</p

Additional file 5 of Afatinib combined with anlotinib in the treatment of lung adenocarcinoma patient with novel HER2 mutation: a case report and review of the literature

Additional file 5

Additional file 2 of Afatinib combined with anlotinib in the treatment of lung adenocarcinoma patient with novel HER2 mutation: a case report and review of the literature

Additional file 2

Additional file 4 of Afatinib combined with anlotinib in the treatment of lung adenocarcinoma patient with novel HER2 mutation: a case report and review of the literature

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Additional file 3 of Afatinib combined with anlotinib in the treatment of lung adenocarcinoma patient with novel HER2 mutation: a case report and review of the literature

Additional file 3

Additional file 1 of Afatinib combined with anlotinib in the treatment of lung adenocarcinoma patient with novel HER2 mutation: a case report and review of the literature

Additional file 1

Additional file 1 of Xp22.31 copy number variations in 87 fetuses: refined genotype–phenotype correlations by prenatal and postnatal follow-up

Additional file1 Table S1. Characterization of the Xp22.31 duplication for each female fetu

DataSheet_1_Roburic Acid Targets TNF to Inhibit the NF-κB Signaling Pathway and Suppress Human Colorectal Cancer Cell Growth.pdf

Tumor necrosis factor (TNF)-stimulated nuclear factor-kappa B (NF-κB) signaling plays very crucial roles in cancer development and progression, and represents a potential target for drug discovery. Roburic acid is a newly discovered tetracyclic triterpene acid isolated from oak galls and exhibits anti-inflammatory activity. However, whether roburic acid exerts antitumor effects through inhibition of TNF-induced NF-κB signaling remains unknown. Here, we demonstrated that roburic acid bound directly to TNF with high affinity (KD = 7.066 μM), blocked the interaction between TNF and its receptor (TNF-R1), and significantly inhibited TNF-induced NF-κB activation. Roburic acid exhibited antitumor activity in numerous cancer cells and could effectively induce G0/G1 cell cycle arrest and apoptosis in colorectal cancer cells. Importantly, roburic acid inhibited the TNF-induced phosphorylation of IKKα/β, IκBα, and p65, degradation of IκBα, nuclear translocation of p65, and NF-κB-target gene expression, including that of XIAP, Mcl-1, and Survivin, in colorectal cancer cells. Moreover, roburic acid suppressed tumor growth by blocking NF-κB signaling in a xenograft nude mouse model of colorectal cancer. Taken together, our findings showed that roburic acid directly binds to TNF with high affinity, thereby disrupting its interaction with TNF-R1 and leading to the inhibition of the NF-κB signaling pathway, both in vitro and in vivo. The results indicated that roburic acid is a novel TNF-targeting therapeutics agent in colorectal cancer as well as other cancer types.</p