One-Step Preparation of Highly Monodisperse Micron-Size Particles in Organic Solvents

In this communication, we report the first simple and fast one-step method for synthesizing highly monodisperse micron-size PMMA particles in organic media through dispersion polymerization in the presence of PHSA (a polyhydroxyl-stearic-acid graft PMMA copolymer) as a stabilizer. There are two significant advantages of our method over earlier methods. First, by optimizing the composition of a solvent mixture of hexane and dodecane, we were able to increase the concentration of monomer up to 50−56% and obtain unusually large (up to 10 μm in diameter) PMMA particles. Second, by strictly controlling the nucleation time, we were able to make PMMA particles with a low polydispersity of around 1%, much lower than has ever before been achieved for such large particles. We also report an unusual apparent metastable state in the nucleation stage

One-Step Preparation of Highly Monodisperse Micron-Size Particles in Organic Solvents

In this communication, we report the first simple and fast one-step method for synthesizing highly monodisperse micron-size PMMA particles in organic media through dispersion polymerization in the presence of PHSA (a polyhydroxyl-stearic-acid graft PMMA copolymer) as a stabilizer. There are two significant advantages of our method over earlier methods. First, by optimizing the composition of a solvent mixture of hexane and dodecane, we were able to increase the concentration of monomer up to 50−56% and obtain unusually large (up to 10 μm in diameter) PMMA particles. Second, by strictly controlling the nucleation time, we were able to make PMMA particles with a low polydispersity of around 1%, much lower than has ever before been achieved for such large particles. We also report an unusual apparent metastable state in the nucleation stage

Marangoni Effect Reverses Coffee-Ring Depositions

We show here both experimentally and theoretically that the formation of “coffee-ring” deposits observed at the edge of drying water droplets requires not only a pinned contact line (Deegan et al. Nature 1997, 389, 827) but also suppression of Marangoni flow. For simple organic fluids, deposition actually occurs preferentially at the center of the droplet, due to a recirculatory flow driven by surface-tension gradients produced by the latent heat of evaporation. The manipulation of this Marangoni flow in a drying droplet should allow one in principle to control and redirect evaporation-driven deposition and assembly of colloids and other materials

Serum calprotectin correlates with risk and disease severity of ankylosing spondylitis and its change during first month might predict favorable response to treatment

Objectives: To investigate the association of serum calprotectin with risk and severity of ankylosing spondylitis (AS), and to study its value for predicting treatment responses. Methods: 262 AS patients and 260 health controls (HCs) were enrolled in this study. 142 active AS patients were treated by pharmaceutical therapy and clinical response was evaluated according to ASAS 40 improvement criteria. 4 ml blood sample was collected from AS patients and HCs at enrollment, and from 142 active AS patients at month 1, 3 and 6 after treatments. And, serum calprotectin, IL-1β, IL-17 and TNF-α expressions were assessed by Enzyme-linked immune sorbent assay (ELISA). Results: The expression of calprotectin in AS patients was remarkably higher compared to HCs, and Receiver Operating Curve (ROC) analysis showed that baseline calprotectin was of great diagnostic value for AS. Calprotectin level was positively correlated with CRP, ESR, PGA, pain VAS, BASDAI and BASFI scores, moreover, patients with higher calprotectin levels were with elevated expressions of IL-1β, IL-17 and TNF-α. Post-treatment, the calprotectin levels of active AS patients notably decreased from baseline to 1, 3 or 6 month. Additionally, patients achieved ASAS 40 were with more considerable change in calprotectin level during first month, and change of calprotectin during first month could predict patients achieving ASAS 40 with AUC of 0.691. Conclusion: Serum calprotectin level could be a promising biomarker for risk and severity of AS, and change of calprotectin during first month post-treatment might predict more favorable treatment response in active AS patients.</p

Data_Sheet_1_Integrative proteomics and metabolomics of Guizhou Miao Sour Soup affecting simple obese rats.XLSX

Miao Sour Soup (MSS) is a fermented product from the Qiandongnan region of Guizhou Province, which enrich many beneficial ingredients and is widely consumed in the whole China. Fermented food is beneficial to physical health with the potential positive regulating affection on simple obesity. In this study, we analyzed the mechanism of action of MSS to prevent simple obesity induced by high-fat diet by proteomics and metabolomics. Quantitative proteomics with tandem mass tagging labeling and liquid chromatography-mass spectrometry was used to analyze the changes of liver proteins and metabolites after the MSS intervention. MSS intervention upregulated 33 proteins and 9 metabolites and downregulated 19 proteins and 10 metabolites. Bioinformatics analysis showed that MSS could prevent simple obesity by acting on the PPAR signaling pathway, retinol metabolism, fatty acid β-oxidation, fatty acid degradation, fatty acid biosynthesis, glycine, serine and threonine metabolism, pyruvate metabolism, citrate cycle (TCA cycle) and other signaling pathways. This study provides new insights into the use of MSS to prevent simple obesity caused by high-fat diets and the search for healthy eating patterns with MSS.</p

Table_2_Integrative proteomics and metabolomics of Guizhou Miao Sour Soup affecting simple obese rats.XLSX

Miao Sour Soup (MSS) is a fermented product from the Qiandongnan region of Guizhou Province, which enrich many beneficial ingredients and is widely consumed in the whole China. Fermented food is beneficial to physical health with the potential positive regulating affection on simple obesity. In this study, we analyzed the mechanism of action of MSS to prevent simple obesity induced by high-fat diet by proteomics and metabolomics. Quantitative proteomics with tandem mass tagging labeling and liquid chromatography-mass spectrometry was used to analyze the changes of liver proteins and metabolites after the MSS intervention. MSS intervention upregulated 33 proteins and 9 metabolites and downregulated 19 proteins and 10 metabolites. Bioinformatics analysis showed that MSS could prevent simple obesity by acting on the PPAR signaling pathway, retinol metabolism, fatty acid β-oxidation, fatty acid degradation, fatty acid biosynthesis, glycine, serine and threonine metabolism, pyruvate metabolism, citrate cycle (TCA cycle) and other signaling pathways. This study provides new insights into the use of MSS to prevent simple obesity caused by high-fat diets and the search for healthy eating patterns with MSS.</p

Data_Sheet_2_Integrative proteomics and metabolomics of Guizhou Miao Sour Soup affecting simple obese rats.XLSX

Miao Sour Soup (MSS) is a fermented product from the Qiandongnan region of Guizhou Province, which enrich many beneficial ingredients and is widely consumed in the whole China. Fermented food is beneficial to physical health with the potential positive regulating affection on simple obesity. In this study, we analyzed the mechanism of action of MSS to prevent simple obesity induced by high-fat diet by proteomics and metabolomics. Quantitative proteomics with tandem mass tagging labeling and liquid chromatography-mass spectrometry was used to analyze the changes of liver proteins and metabolites after the MSS intervention. MSS intervention upregulated 33 proteins and 9 metabolites and downregulated 19 proteins and 10 metabolites. Bioinformatics analysis showed that MSS could prevent simple obesity by acting on the PPAR signaling pathway, retinol metabolism, fatty acid β-oxidation, fatty acid degradation, fatty acid biosynthesis, glycine, serine and threonine metabolism, pyruvate metabolism, citrate cycle (TCA cycle) and other signaling pathways. This study provides new insights into the use of MSS to prevent simple obesity caused by high-fat diets and the search for healthy eating patterns with MSS.</p

Table_1_Integrative proteomics and metabolomics of Guizhou Miao Sour Soup affecting simple obese rats.XLSX

Miao Sour Soup (MSS) is a fermented product from the Qiandongnan region of Guizhou Province, which enrich many beneficial ingredients and is widely consumed in the whole China. Fermented food is beneficial to physical health with the potential positive regulating affection on simple obesity. In this study, we analyzed the mechanism of action of MSS to prevent simple obesity induced by high-fat diet by proteomics and metabolomics. Quantitative proteomics with tandem mass tagging labeling and liquid chromatography-mass spectrometry was used to analyze the changes of liver proteins and metabolites after the MSS intervention. MSS intervention upregulated 33 proteins and 9 metabolites and downregulated 19 proteins and 10 metabolites. Bioinformatics analysis showed that MSS could prevent simple obesity by acting on the PPAR signaling pathway, retinol metabolism, fatty acid β-oxidation, fatty acid degradation, fatty acid biosynthesis, glycine, serine and threonine metabolism, pyruvate metabolism, citrate cycle (TCA cycle) and other signaling pathways. This study provides new insights into the use of MSS to prevent simple obesity caused by high-fat diets and the search for healthy eating patterns with MSS.</p

Additional file 1 of Identification of gene biomarkers for brain diseases via multi-network topological semantics extraction and graph convolutional network

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Additional file 1 of Does social participation decrease the risk of frailty? Impacts of diversity in frequency and types of social participation on frailty in middle-aged and older populations

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