48 research outputs found

    Transition-Metal-Free Regioselective Cross-Coupling: Controlled Synthesis of Mono- or Dithiolation Indolizines

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    An efficient transition-metal-free regioselective C–H/S–H cross-coupling of indolizines with thiols has been developed for the first time to describe a workable route to indolizine thioethers. This finding provides a new method and more straightforward pathway for controllable synthesis of mono- or dithiolation indolizines that are otherwise difficult to obtain by the literature methods. The reaction exhibits good functional group tolerance and high efficiency and affords the products in good to excellent yields

    Ag-Catalyzed Tandem Three-Component Reaction toward the Synthesis of Multisubstituted Imidazoles

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    A facile one-pot, Ag-catalyzed tandem three-component reaction of amidines, ynals, and carboxylic acids or amines to form imidazole skeletons has been developed. This multicomponent reaction has been applied to various substituted amidines and carboxylic acids substrates, affording the products in good yields. The strategy could provide an efficient and green molecular fragment assembly to access imidazoles

    A Carbonylation Approach Toward Activation of C<sub>sp2</sub>-H and C<sub>sp3</sub>-H Bonds: Cu-Catalyzed Regioselective Cross Coupling of Imidazo[1,2‑<i>a</i>]pyridines with Methyl Hetarenes

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    An efficient copper-catalyzed selective cross coupling of imidazo­[1,2-<i>a</i>]­pyridines with methyl hetarenes has been reported. This transformation opened a new route to synthesize the C-3 carbonyl imidazo­[1,2-<i>a</i>]­pyridine derivative, which is a common structural motif in natural products and pharmaceuticals. <sup>18</sup>O-labeling experiments indicated that the oxygen source of products originated from O<sub>2</sub>

    One-Pot Regiospecific Synthesis of Indolizines: A Solvent-Free, Metal-Free, Three-Component Reaction of 2‑(Pyridin-2-yl)acetates, Ynals, and Alcohols or Thiols

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    A novel approach for the synthesis of indolizines from 2-(pyridin-2-yl)­acetates, ynals, and alcohols or thiols has been developed. This MCR (multicomponent reaction) that proceeds under the solvent- and metal-free conditions has provided a straightforward path to construct indolizines. Furthermore, this reaction demonstrates other attractive features such as widely available starting materials, mild conditions, good functional group tolerance, and high efficiency

    Direct Arylation of Imidazo[1,2-<i>a</i>]pyridine at C-3 with Aryl Iodides, Bromides, and Triflates via Copper(I)-Catalyzed C–H Bond Functionalization

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    A convenient method for the copper(I)-catalyzed arylation of substituted imidazo[1,2-<i>a</i>]pyridine has been developed. This method is applicable to a variety of aryl electrophiles, including bromides, iodides, and triflates. It represents the first general process for C-3 arylation of substituted imidazo[1,2-<i>a</i>]pyridine by Cu(I) catalysis to construct various functionalized imidazo[1,2-<i>a</i>]pyridine core π-systems

    Synthesis of (Furyl)Methyl Disulfides via Tandem Reaction of Conjugated Ene-Yne-Ketones with Acetyl-Masked Disulfide Nucleophiles

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    In this study, we outline a general method for the construction of various (furyl)methyl disulfides from acetyl-masked disulfide nucleophiles and ene-yne-ketones. This protocol is feathered by metal-free, simple experimental conditions, high efficiency, and scalable potential, which make it attractive and practical

    Heat tolerance testing of <i>Arabidopsis</i> wild-type (WT) and <i>myb33myb65</i> double mutant plants.

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    <p>(A) Phenotype of WT and <i>myb33myb65</i> 2-weeks-old seedlings after heat stress for 4 hr at 44°C Identical samples was planted diagonally. WT seedlings were planted in the northwest and southeast corners, while double mutant seedlings were planted in the other two corners as indicated in the schematic. (B) Relative electrical conductivity test of WT and <i>myb33myb65</i> double mutants after heat treatment.</p

    Detection of Ad14 PtDd by Western blot analysis.

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    <p>HeLa cells were infected with wild-type Ad3, Ad14, and Ad5 at an MOI of 500 vp/cell for 7 hours. Thirty-six hours after infection, cell lysates were subjected to ultracentrifugation on a sucrose gradient. Fractions were analyzed by Western blot using a polycloncal antibody against Ad3 PtDd, which also cross-reacts with Ad5 and Ad14 penton base.</p
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