48 research outputs found
Transition-Metal-Free Regioselective Cross-Coupling: Controlled Synthesis of Mono- or Dithiolation Indolizines
An efficient transition-metal-free
regioselective C–H/S–H
cross-coupling of indolizines with thiols has been developed for the
first time to describe a workable route to indolizine thioethers.
This finding provides a new method and more straightforward pathway
for controllable synthesis of mono- or dithiolation indolizines that
are otherwise difficult to obtain by the literature methods. The reaction
exhibits good functional group tolerance and high efficiency and affords
the products in good to excellent yields
Ag-Catalyzed Tandem Three-Component Reaction toward the Synthesis of Multisubstituted Imidazoles
A facile
one-pot, Ag-catalyzed tandem three-component reaction
of amidines, ynals, and carboxylic acids or amines to form imidazole
skeletons has been developed. This multicomponent reaction has been
applied to various substituted amidines and carboxylic acids substrates,
affording the products in good yields. The strategy could provide
an efficient and green molecular fragment assembly to access imidazoles
A Carbonylation Approach Toward Activation of C<sub>sp2</sub>-H and C<sub>sp3</sub>-H Bonds: Cu-Catalyzed Regioselective Cross Coupling of Imidazo[1,2‑<i>a</i>]pyridines with Methyl Hetarenes
An
efficient copper-catalyzed selective cross coupling of imidazoÂ[1,2-<i>a</i>]Âpyridines with methyl hetarenes has been reported. This
transformation opened a new route to synthesize the C-3 carbonyl imidazoÂ[1,2-<i>a</i>]Âpyridine derivative, which is a common structural motif
in natural products and pharmaceuticals. <sup>18</sup>O-labeling experiments
indicated that the oxygen source of products originated from O<sub>2</sub>
One-Pot Regiospecific Synthesis of Indolizines: A Solvent-Free, Metal-Free, Three-Component Reaction of 2‑(Pyridin-2-yl)acetates, Ynals, and Alcohols or Thiols
A novel
approach for the synthesis of indolizines from 2-(pyridin-2-yl)Âacetates,
ynals, and alcohols or thiols has been developed. This MCR (multicomponent
reaction) that proceeds under the solvent- and metal-free conditions
has provided a straightforward path to construct indolizines. Furthermore,
this reaction demonstrates other attractive features such as widely
available starting materials, mild conditions, good functional group
tolerance, and high efficiency
Direct Arylation of Imidazo[1,2-<i>a</i>]pyridine at C-3 with Aryl Iodides, Bromides, and Triflates via Copper(I)-Catalyzed C–H Bond Functionalization
A convenient method for the copper(I)-catalyzed arylation of substituted imidazo[1,2-<i>a</i>]pyridine has been developed. This method is applicable to a variety of aryl electrophiles, including bromides, iodides, and triflates. It represents the first general process for C-3 arylation of substituted imidazo[1,2-<i>a</i>]pyridine by Cu(I) catalysis to construct various functionalized imidazo[1,2-<i>a</i>]pyridine core π-systems
Synthesis of (Furyl)Methyl Disulfides via Tandem Reaction of Conjugated Ene-Yne-Ketones with Acetyl-Masked Disulfide Nucleophiles
In
this study, we outline a general method for the construction
of various (furyl)methyl disulfides from acetyl-masked disulfide nucleophiles
and ene-yne-ketones. This protocol is feathered by metal-free, simple
experimental conditions, high efficiency, and scalable potential,
which make it attractive and practical
Heat tolerance testing of <i>Arabidopsis</i> wild-type (WT) and <i>myb33myb65</i> double mutant plants.
<p>(A) Phenotype of WT and <i>myb33myb65</i> 2-weeks-old seedlings after heat stress for 4 hr at 44°C Identical samples was planted diagonally. WT seedlings were planted in the northwest and southeast corners, while double mutant seedlings were planted in the other two corners as indicated in the schematic. (B) Relative electrical conductivity test of WT and <i>myb33myb65</i> double mutants after heat treatment.</p
Mann-Whitney U test of family burden of OSA patients with depressive status by Family Burden Scale.
<p>Mann-Whitney U test of family burden of OSA patients with depressive status by Family Burden Scale.</p
Mann-Whitney U test of family care of OSA patients with depressive status by Family APGAR scale.
<p>Mann-Whitney U test of family care of OSA patients with depressive status by Family APGAR scale.</p
Detection of Ad14 PtDd by Western blot analysis.
<p>HeLa cells were infected with wild-type Ad3, Ad14, and Ad5 at an MOI of 500 vp/cell for 7 hours. Thirty-six hours after infection, cell lysates were subjected to ultracentrifugation on a sucrose gradient. Fractions were analyzed by Western blot using a polycloncal antibody against Ad3 PtDd, which also cross-reacts with Ad5 and Ad14 penton base.</p