A Solution to Co-occurrence Bias: Attributes Disentanglement via Mutual Information Minimization for Pedestrian Attribute Recognition

Recent studies on pedestrian attribute recognition progress with either explicit or implicit modeling of the co-occurrence among attributes. Considering that this known a prior is highly variable and unforeseeable regarding the specific scenarios, we show that current methods can actually suffer in generalizing such fitted attributes interdependencies onto scenes or identities off the dataset distribution, resulting in the underlined bias of attributes co-occurrence. To render models robust in realistic scenes, we propose the attributes-disentangled feature learning to ensure the recognition of an attribute not inferring on the existence of others, and which is sequentially formulated as a problem of mutual information minimization. Rooting from it, practical strategies are devised to efficiently decouple attributes, which substantially improve the baseline and establish state-of-the-art performance on realistic datasets like PETAzs and RAPzs. Code is released on https://github.com/SDret/A-Solution-to-Co-occurence-Bias-in-Pedestrian-Attribute-Recognition.Comment: Accepted in IJCAI2

Gender effects on cytidine analogue metabolism and myelodysplastic syndrome treatment outcomes

In vivo, half-lives of cytidine analogues such as 5-azacytidine and decitabine, used to treat myelodysplastic syndromes (MDS), are determined largely by cytidine deaminase (CDA), an enzyme that rapidly metabolizes these drugs into inactive uridine counterparts. Genetic factors influence CDA activity, and hence, could impact 5-azacytidine/decitabine levels and efficacy, a possibility requiring evaluation. Using an HPLC assay, plasma CDA activity was confirmed to be decreased in individuals with the CDA SNP A79C. More interestingly, there was an even larger decrease in females. Explaining the decrease in enzyme activity, liver CDA expression was significantly lower in female versus male mice. As expected, decitabine plasma levels, measured by mass-spectrometry, were significantly higher in females. In mathematical modeling, the detrimental effect of shortening half-life of S-phase specific therapy was amplified in low S-phase fraction disease (e.g., MDS). Accordingly, in multivariate analysis of MDS patients treated with 5-azacytidine/decitabine, overall survival was significantly worse in males

p53 independent epigenetic-differentiation treatment in xenotransplant models of acute myeloid leukemia

Suppression of apoptosis by TP53 mutation contributes to resistance of acute myeloid leukemia (AML) to conventional cytotoxic treatment. Using differentiation to induce irreversible cell cycle exit in AML cells could be a p53-independent treatment alternative, however, this possibility requires evaluation. In vitro and in vivo regimens of the cytosine analogue decitabine that deplete the chromatin modifying enzyme DNA methyl-transferase 1 (DNMT1) without phosphorylating p53 or inducing early apoptosis were determined. These decitabine regimens but not equimolar DNA-damaging cytarabine up regulated the key late differentiation factors CEBPε and p27/CDKN1B, induced cellular differentiation, and terminated AML cell-cycle, even in cytarabine-resistant p53- and p16/CDKN2A-null AML cells. Leukemia initiation by xeno-transplanted AML cells was abrogated but normal hematopoietic stem cell (HSC) engraftment was preserved. In vivo, the low toxicity allowed frequent drug administration to increase exposure, an important consideration for S-phase specific decitabine therapy. In xeno-transplant models of p53-null and relapsed/refractory AML, the non-cytotoxic regimen significantly extended survival compared to conventional cytotoxic cytarabine. Modifying in vivo dose and schedule to emphasize this pathway of decitabine action can bypass a mechanism of resistance to standard therapy

Detecting Silent Data Corruptions in Aerospace-Based Computing Using Program Invariants

Soft error caused by single event upset has been a severe challenge to aerospace-based computing. Silent data corruption (SDC) is one of the results incurred by soft error. SDC occurs when a program generates erroneous output with no indications. SDC is the most insidious type of results and very difficult to detect. To address this problem, we design and implement an invariant-based system called Radish. Invariants describe certain properties of a program; for example, the value of a variable equals a constant. Radish first extracts invariants at key program points and converts invariants into assertions. It then hardens the program by inserting the assertions into the source code. When a soft error occurs, assertions will be found to be false at run time and warn the users of soft error. To increase the coverage of SDC, we further propose an extension of Radish, named Radish_D, which applies software-based instruction duplication mechanism to protect the uncovered code sections. Experiments using architectural fault injections show that Radish achieves high SDC coverage with very low overhead. Furthermore, Radish_D provides higher SDC coverage than that of either Radish or pure instruction duplication

Rates and kinematics of active shortening along the eastern Qilian Shan, China, inferred from deformed fluvial terraces

In the eastern Qilian Shan, a flight of fluvial terraces developed along the Jinta River valley are deformed across the Nanying anticline. Four individual fluvial terraces are preserved at different elevations above the river, and higher terrace treads are draped by systematically thicker aeolian loess. Optically stimulated luminescence dating of deposits at the base of the loess provides constraints on the timing of surface abandonment; terraces were abandoned at 69 ± 4 ka B.P. (T4), 57 ± 4 ka B.P. (T3), and between 34 ± 3 ka B.P. (T2), respectively. Differential GPS measurement of the terrace profile across the anticline allows reconstruction of subsurface fault geometry; we model terrace deformation above a listric thrust fault with a tip line at 2.2 ± 0.1 km depth and whose dip shallows systematically to 23 ± 3° at depth of 5.8 ± 1.1 km. Combining terrace ages with this model of fault geometry, we estimate a shortening rate of 0.8 ± 0.2 mm/a across the Nanying fold and a shortening rate of ~0.1 mm/a across the mountain front fault since ~70 ka B.P. This rate suggests that the frontal fault system along the eastern Qilian Shan accomplishes crustal shortening at rates of approximately 0.9 ± 0.3 mm/a during late Pleistocene time.This is the publisher’s final pdf. The article is copyrighted by American Geophysical Union and published by John Wiley & Sons, Inc. It can be found at: http://agupubs.onlinelibrary.wiley.com/agu/journal/10.1002/%28ISSN%291944-9194

The coupling between tectonic uplift and climate change recorded by the Yellow River terraces during the Zoige basin excavation in the northeastern Tibetan Plateau

Understanding the processes of fluvial geomorphic evolution is based on thorough evaluation of how rivers respond to tectonic activity and climatic change, with river terraces representing a key archive of alternating deposition and incision in response to such forcing, enabling an excellent means for correlation with tectonic and climatic records. An example presented here points to a difference in fluvial response to climate fluctuations along a trunk river and its tributary: the Yellow River and its tributary the Xike River, which has incised the Lajia Gorge to pirate the Zoige Basin, in the eastern Tibetan Plateau. Based on Accelerator Mass Spectrometry 14C dating, the chronological sequence of basin fill top and fluvial terraces below has been established, defining the drainage reorganization of the Yellow River excavation through the Zoige Basin since the Last Glacial Maximum. Spatial and stratigraphic comparison between the two fluvial sequences, combined with correlation with high-resolution climatic records, indicates that the tributary Xike River formed more terraces in response to trunk incision (base-level variation), climatic fluctuations, and underlying weak bedrock than the Yellow River. Thus, our results not only demonstrate a combined archive of climatic fluctuation and tectonic uplift recorded in the fluvial terrace sequences, but also suggest that the generation of fluvial terraces may be influenced by the underlying bedrock within the same tectonic and climatic settings

Sciences for The 2.5-meter Wide Field Survey Telescope (WFST)

The Wide Field Survey Telescope (WFST) is a dedicated photometric survey facility under construction jointly by the University of Science and Technology of China and Purple Mountain Observatory. It is equipped with a primary mirror of 2.5m in diameter, an active optical system, and a mosaic CCD camera of 0.73 Gpix on the main focus plane to achieve high-quality imaging over a field of view of 6.5 square degrees. The installation of WFST in the Lenghu observing site is planned to happen in the summer of 2023, and the operation is scheduled to commence within three months afterward. WFST will scan the northern sky in four optical bands (u, g, r, and i) at cadences from hourly/daily to semi-weekly in the deep high-cadence survey (DHS) and the wide field survey (WFS) programs, respectively. WFS reaches a depth of 22.27, 23.32, 22.84, and 22.31 in AB magnitudes in a nominal 30-second exposure in the four bands during a photometric night, respectively, enabling us to search tremendous amount of transients in the low-z universe and systematically investigate the variability of Galactic and extragalactic objects. Intranight 90s exposures as deep as 23 and 24 mag in u and g bands via DHS provide a unique opportunity to facilitate explorations of energetic transients in demand for high sensitivity, including the electromagnetic counterparts of gravitational-wave events detected by the second/third-generation GW detectors, supernovae within a few hours of their explosions, tidal disruption events and luminous fast optical transients even beyond a redshift of 1. Meanwhile, the final 6-year co-added images, anticipated to reach g about 25.5 mag in WFS or even deeper by 1.5 mag in DHS, will be of significant value to general Galactic and extragalactic sciences. The highly uniform legacy surveys of WFST will also serve as an indispensable complement to those of LSST which monitors the southern sky.Comment: 46 pages, submitted to SCMP