Determination of Stray Inductance of Low-Inductive Laminated Planar Multiport Busbars Using Vector Synthesis Method

Laminated busbars connect capacitors with switching power modules, and they are designed to have low stray inductance to minimize electromagnetic interference. Attempts to accurately measure the stray inductance of these busbars have not been successful. The challenge lies with the capacitors, as they excite the busbar producing their individual stray inductances. These individual stray inductances cannot be arithmetically averaged to establish the total stray inductance that applies when all the capacitors excite the busbar at the same time. It is also not possible to measure the stray inductance by simultaneous excitation of each capacitor port using impedance analyzers. This paper presents a solution to the above dilemma. A vector synthesis method is proposed, whereby the individual stray inductance from each capacitor port is measured using an impedance analyzer. Each stray inductance is then mapped into an xyz frame with a distinct direction. This mapping exercise allows the data to be vectored. The total stray inductance is then the sum of all the vectors. The effectiveness of the proposed method is demonstrated on a busbar designed for H-bridge inverters by comparing the simulation and practical results. The absolute error of the total stray inductance between the simulation and the proposed method is 0.48 nH. The proposed method improves the accuracy by 14.9% compared to the conventional technique in measuring stray inductances

Positive response to trastuzumab deruxtecan in a patient with HER2-mutant NSCLC after multiple lines therapy, including T-DM1: a case report

Human epidermal growth factor 2 (HER2) mutations are uncommon in non-small cell lung cancer (NSCLC), and the lack of established, effective, targeted drugs has resulted in a persistently poor prognosis. Herein, we report the case of a non-smoking, 58-year-old man diagnosed with lung adenocarcinoma (cT3N0M1c, stage IVB) harboring a HER2 mutation (Y772_A775dupYVMA) and PD-L1 (-). The patient’s Eastern Cooperative Oncology Group performance status (PS) score was assessed as 1. He commenced first-line treatment with chemotherapy, followed by immuno-chemotherapy, and with disease progression, he received HER2-targeted therapy and chemotherapy with an anti-angiogenic agent. However, HER2-targeted therapy, including pan-HER tyrosine kinase inhibitors (afatinib, pyrotinib, and pozitinib) and antibody–drug conjugate (T-DM1), produced only stable disease (SD) as the best response. After the previously described treatment, primary tumor recurrence and multiple brain metastases were observed. Despite the patient’s compromised overall physical condition with a PS score of 3-4, he was administered T-DXd in addition to whole-brain radiotherapy (WBRT). Remarkably, both intracranial metastases and primary lesions were significantly reduced, he achieved a partial response (PR), and his PS score increased from 3-4 to 1. He was then treated with T-DXd for almost 9 months until the disease again progressed, and he did not discontinue the drug despite the occurrence of myelosuppression during this period. This is a critical case as it exerted an effective response to T-DXd despite multiple lines therapy, including T-DM1. Simultaneously, despite the occurrence of myelosuppression in the patient during T-DXd, it was controlled after aggressive treatment

QCR7 affects the virulence of Candida albicans and the uptake of multiple carbon sources present in different host niches

BackgroundCandida albicans is a commensal yeast that may cause life-threatening infections. Studies have shown that the cytochrome b-c1 complex subunit 7 gene (QCR7) of C. albicans encodes a protein that forms a component of the mitochondrial electron transport chain complex III, making it an important target for studying the virulence of this yeast. However, to the best of our knowledge, the functions of QCR7 have not yet been characterized.MethodsA QCR7 knockout strain was constructed using SN152, and BALb/c mice were used as model animals to determine the role of QCR7 in the virulence of C. albicans. Subsequently, the effects of QCR7 on mitochondrial functions and use of carbon sources were investigated. Next, its mutant biofilm formation and hyphal growth maintenance were compared with those of the wild type. Furthermore, the transcriptome of the qcr7Δ/Δ mutant was compared with that of the WT strain to explore pathogenic mechanisms.ResultsDefective QCR7 reduced recruitment of inflammatory cells and attenuated the virulence of C. albicans infection in vivo. Furthermore, the mutant influenced the use of multiple alternative carbon sources that exist in several host niches (GlcNAc, lactic acid, and amino acid, etc.). Moreover, it led to mitochondrial dysfunction. Furthermore, the QCR7 knockout strain showed defects in biofilm formation or the maintenance of filamentous growth. The overexpression of cell-surface-associated genes (HWP1, YWP1, XOG1, and SAP6) can restore defective virulence phenotypes and the carbon-source utilization of qcr7Δ/Δ.ConclusionThis study provides new insights into the mitochondria-based metabolism of C. albicans, accounting for its virulence and the use of variable carbon sources that promote C. albicans to colonize host niches

Analysis of spatial patterns of technological innovation capability based on patent data in Jiangsu province, China

Abstract Innovation is the main driver of regional economic development. Exploring the spatial patterns of regional innovation can elucidate the regional differences in innovation development. Nearly all the researches on spatial patterns of innovation take the administrative divisions of provinces, cities and counties as spatial units, and portray the spatial patterns of regional innovation from the macroscopic overall, but lack the spatial patterns within the regions. This paper employed patents of Jiangsu province, China in 2019 as a sample, divided the spatial units based on geographic coordinates of patent data, calculated the technological innovation capability index of within the spatial units, overcoming the drawbacks of the research method that fails to reveal the internal pattern of cities by using provinces, cities and counties as the research scale, and analysed the spatial patterns of technological innovation capability in Jiangsu province by using spatial autocorrelation analysis and standard deviation ellipse. The results show that: (1) In terms of distribution, the spatial pattern of technological innovation capability in Jiangsu province is obviously “one core and one belt” in southern Jiangsu, with Nanjing as the core and Suzhou, Wuxi and Changzhou as a southeast-northwest belt of high innovation capacity, while multi-point scattered in northern Jiangsu. (2) From the perspective of aggregation mode, each city has the largest number of H-H agglomeration units, relatively presenting a zonal distribution in the Suzhou-Wuxi-Changzhou area and Nanjing, and less distribution in other places. (3) Industrially speaking, the development of technological innovation capability of the secondary industry in many cities is better and centralized, while secondary and tertiary industries move hand in hand around the city centre in Nanjing, and the tertiary industry dominates comparably in Suzhou and Wuxi