Structural and Dynamic Histomorphometric Parameters of Experimental Chronic Kidney Disease Rats that did or did not Undergo Parathyroidectomy.^*

<p>*N = 26 rats. Data reported as mean ± SD. Abbreviations: CKD, chronic kidney disease; PTX+CKD, parathyroidectomy and chronic kidney disease; MS/BS, percent mineralized bone surface; MAR, mineral apposition rate; BFR, bone formation rate; OV/BV, osteoid volume ratio; OS/BS, osteoid surface ratio; O.Th, osteoid thickness; OMT, osteoid maturation time</p><p>^ap < 0.01, compared with sham-operated control group.</p><p>^bp < 0.01, compared with CKD group.</p><p>^cp < 0.05, compared with sham-operated control group.</p><p>^dp < 0.05, compared with CKD group. NS, no significant (p > 0.05)</p><p>Structural and Dynamic Histomorphometric Parameters of Experimental Chronic Kidney Disease Rats that did or did not Undergo Parathyroidectomy.^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0133278#t001fn001" target="_blank">*</a>}</p

Dynamic bone histomorphometry with calcein-fluorescent labeling.

<p>The distance between the 2 lines of calcein label is greater in the chronic kidney disease (CKD) than in the control group. The PTX and chronic kidney disease (PTX+CKD) group had fewer areas with 2 labels, and the distance between the 2 lines of calcein label was smaller, indicating lower bone turnover in the PTX+CKD than in the CKD group. Scale bar = 50 μm.</p

Comparison of serum biochemical parameters between control CKD and PTX +CKD group.

<p>(A) Serum phosphate levels. (B) Serum calcium levels. (C) Serum intact PTH levels. (D) Serum FGF-23 levels. (E) Serum Vitamin D (1,25-(OH)₂D₃) levels. (F) Serum ALP levels. (G) Serum osteocalcin levels. (H) Serum CTX levels. n = 8 control, n = 9 CKD, n = 9 PTX +CKD. Results were presented as mean ± SEM. * p < 0.05, ** p < 0.01, *** p < 0.001.</p