Millimeter-wave diode-grid phase shifters

Monolithic diode grids have been fabricated on 2-cm square gallium-arsenide wafers with 1600 Schottky-barrier varactor diodes. Shorted diodes are detected with a liquid-crystal technique, and the bad diodes are removed with an ultrasonic probe. A small-aperture reflectometer that uses wavefront division interference was developed to measure the reflection coefficient of the grids. A Phase shift of 70° with a 7-dB loss was obtained at 93 GHz when the bias on the diode grid was changed from -3 V to 1 V. A simple transmission-line grid model, together with the measured low-frequency parameters for the diodes, was shown to predict the measured performance over the entire capacitive bias range of the diodes, as well as over the complete reactive tuning range provided by a reflector behind the grid, and over a wide range of frequencies form 33 GHz to 141 GHz. This shows that the transmission-line model and the measured low-frequency diode parameters can be used to design an electronic beam-steering array and to predict its performance. An electronic beam-steering array made of a pair of grids using state-of-the-art diodes with 5-Ω series resistances would have a loss of 1.4 dB at 90 GHz

Followup Observations of SDSS and CRTS Candidate Cataclysmic Variables

We present photometry of 11 and spectroscopy of 35 potential cataclysmic variables from the Sloan Digital Sky Survey, the Catalina Real-Time Transient Survey and vsnet-alerts. The photometry results include quasi-periodic oscillations during the decline of V1363 Cyg, nightly accretion changes in the likely Polar (AM Herculis binary) SDSS J1344+20, eclipses in SDSS J2141+05 with an orbital period of 76+/-2 min, and possible eclipses in SDSS J2158+09 at an orbital period near 100 min. Time-resolved spectra reveal short orbital periods near 80 min for SDSS J0206+20, 85 min for SDSS J1502+33, and near 100 min for CSS J0015+26, RXS J0150+37, SDSS J1132+62, SDSS J2154+15 and SDSS J2158+09. The prominent HeII line and velocity amplitude of SDSS J2154+15 are consistent with a Polar nature for this object, while the lack of this line and a low velocity amplitude argue against this classification for RXS J0150+37. Single spectra of 10 objects were obtained near outburst and the rest near quiescence, confirming the dwarf novae nature of these objects.Comment: 34 pages, 14 figures, in press at A

Kinematics and Composition of the Galactic Bulge: Recent Progress

We present recent results from a Keck study of the composition of the Galactic bulge, as well as results from the bulge Bulge Radial Velocity Assay (BRAVA). Culminating a 10 year investigation, Fulbright, McWilliam, & Rich (2006, 2007) solved the problem of deriving the iron abundance in the Galactic bulge, and find enhanced alpha element abundances, consistent with the earlier work of McWilliam & Rich (1994). We also report on a radial velocity survey of {\sl 2MASS}-selected M giant stars in the Galactic bulge, observed with the CTIO 4m Hydra multi-object spectrograph. This program is to test dynamical models of the bulge and to search for and map any dynamically cold substructure in the Galactic bulge. We show initial results on fields at $-10^{\circ} < l <+10^{\circ}$ and $b=-4^{\circ}$. We construct a longitude-velocity plot for the bulge stars and the model data, and find that contrary to previous studies, the bulge does not rotate as a solid body; from $-5^{\circ}<l<+5^{\circ}$ the rotation curve has a slope of $\approx 100 km s^{-1}$ and flattens considerably at greater $l$ and reaches a maximum rotation of $45 {km s^{-1}}$ (heliocentric) or $\sim 70 {km s^{-1}}$ (Galactocentric). This rotation is slower than that predicted by the dynamical model of Zhao (1996).Comment: 6 pages, 6 figures, contributed paper at IAU Symposium 245 "Formation and Evolution of Galactic Bulges

Sequence heterogeneity and the dynamics of molecular motors

The effect of sequence heterogeneity on the dynamics of molecular motors is reviewed and analyzed using a set of recently introduced lattice models. First, we review results for the influence of heterogenous tracks such as a single-strand of DNA or RNA on the dynamics of the motors. We stress how the predicted behavior might be observed experimentally in anomalous drift and diffusion of motors over a wide range of parameters near the stall force and discuss the extreme limit of strongly biased motors with one-way hopping. We then consider the dynamics in an environment containing a variety of different fuels which supply chemical energy for the motor motion, either on a heterogeneous or on a periodic track. The results for motion along a periodic track are relevant to kinesin motors in a solution with a mixture of different nucleotide triphosphate fuel sources.Comment: To appear in a JPhys special issue on molecular motor

Pricing in the Market for Anticancer Drugs

In 2011, Bristol-Myers Squibb set the price of its newly approved melanoma drug ipilimumab— brand name Yervoy—at $120,000 for a course of therapy. The drug was associated with an incremental increase in life expectancy of four months. Drugs like ipilimumab have fueled the perception that the launch prices of new anticancer drugs and other drugs in the so-called "specialty" pharmaceutical market have been increasing over time and that increases are unrelated to the magnitude of the expected health benefits. In this paper, we discuss the unique features of the market for anticancer drugs and assess trends in the launch prices for 58 anticancer drugs approved between 1995 and 2013 in the United States. We restrict attention to anticancer drugs because the use of median survival time as a primary outcome measure provides a common, objective scale for quantifying the incremental benefit of new products. We find that the average launch price of anticancer drugs, adjusted for inflation and health benefits, increased by 10 percent annually—or an average of$8,500 per year—from 1995 to 2013. We argue that the institutional features of the market for anticancer drugs enable manufacturers to set the prices of new products at or slightly above the prices of existing therapies, giving rise to an upward trend in launch prices. Government-mandated price discounts for certain classes of buyers may have also contributed to launch price increases as firms sought to offset the growth in the discount segment by setting higher prices for the remainder of the market

Assessing the Effect of Stellar Companions from High-Resolution Imaging of Kepler Objects of Interest

We report on 176 close (<2") stellar companions detected with high-resolution imaging near 170 hosts of Kepler Objects of Interest. These Kepler targets were prioritized for imaging follow-up based on the presence of small planets, so most of the KOIs in these systems (176 out of 204) have nominal radii <6 R_E . Each KOI in our sample was observed in at least 2 filters with adaptive optics, speckle imaging, lucky imaging, or HST. Multi-filter photometry provides color information on the companions, allowing us to constrain their stellar properties and assess the probability that the companions are physically bound. We find that 60 -- 80% of companions within 1" are bound, and the bound fraction is >90% for companions within 0.5"; the bound fraction decreases with increasing angular separation. This picture is consistent with simulations of the binary and background stellar populations in the Kepler field. We also reassess the planet radii in these systems, converting the observed differential magnitudes to a contamination in the Kepler bandpass and calculating the planet radius correction factor, $X_R = R_p (true) / R_p (single)$. Under the assumption that planets in bound binaries are equally likely to orbit the primary or secondary, we find a mean radius correction factor for planets in stellar multiples of $X_R = 1.65$. If stellar multiplicity in the Kepler field is similar to the solar neighborhood, then nearly half of all Kepler planets may have radii underestimated by an average of 65%, unless vetted using high resolution imaging or spectroscopy.Comment: 23 pages, 12 figures. Accepted for publication in The Astronomical Journa

A two-state model for helicase translocation and unwinding of nucleic acids

Helicases are molecular motors that unwind double-stranded nucleic acids (dsNA), such as DNA and RNA). Typically a helicase translocates along one of the NA single strands while unwinding and uses adenosine triphosphate (ATP) hydrolysis as an energy source. Here we model of a helicase motor that can switch between two states, which could represent two different points in the ATP hydrolysis cycle. Our model is an extension of the earlier Betterton-J\"ulicher model of helicases to incorporate switching between two states. The main predictions of the model are the speed of unwinding of the dsNA and fluctuations around the average unwinding velocity. Motivated by a recent claim that the NS3 helicase of Hepatitis C virus follows a flashing ratchet mechanism, we have compared the experimental results for the NS3 helicase with a special limit of our model which corresponds to the flashing ratchet scenario. Our model accounts for one key feature of the experimental data on NS3 helicase. However, contradictory observations in experiments carried out under different conditions limit the ability to compare the model to experiments.Comment: minor modification

The Kepler Follow-up Observation Program

The Kepler Mission was launched on March 6, 2009 to perform a photometric survey of more than 100,000 dwarf stars to search for terrestrial-size planets with the transit technique. Follow-up observations of planetary candidates identified by detection of transit-like events are needed both for identification of astrophysical phenomena that mimic planetary transits and for characterization of the true planets and planetary systems found by Kepler. We have developed techniques and protocols for detection of false planetary transits and are currently conducting observations on 177 Kepler targets that have been selected for follow-up. A preliminary estimate indicates that between 24% and 62% of planetary candidates selected for follow-up will turn out to be true planets.Comment: 12 pages, submitted to the Astrophysical Journal Letter

Millimeter-Wave Diode-Grid Frequency Doubler

Monolithic diode grid were fabricated on 2-cm^2 gallium-arsenide wafers in a proof-of-principle test of a quasi-optical varactor millimeter-wave frequency multiplier array concept. An equivalent circuit model based on a transmission-line analysis of plane wave illumination was applied to predict the array performance. The doubler experiments were performed under far-field illumination conditions. A second-harmonic conversion efficiency of 9.5% and output powers of 0.5 W were achieved at 66 GHz when the diode grid was pumped with a pulsed source at 33 GHz. This grid had 760 Schottky-barrier varactor diodes. The average series resistance was 27 Ω, the minimum capacitance was 18 fF at a reverse breakdown voltage of -3 V. The measurements indicate that the diode grid is a feasible device for generating watt-level powers at millimeter frequencies and that substantial improvement is possible by improving the diode breakdown voltage