13 research outputs found

    Bottom-Up Synthesis of Nitrogen-Doped Graphynes for High-Performance Electrocatalysis in a Zn-Air Battery

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    Nitrogen-doped carbon materials have been developing rapidly over the past decade as ideal metal-free electrocatalysts in the oxygen reduction reaction (ORR). Nevertheless, several challenges persist in the postdoping methods, including the uneven distribution of active sites and low nitrogen contents, disturbing the electrocatalytic performances of the obtained materials. In this study, we present a simple and straightforward approach for the in situ synthesis of graphyne-based catalysts via Sonogashira reaction of nitrogen-rich acetylene- and halogene-substituted heterocyclic arenes followed by heat treatment. The obtained catalyst TBGY-800 demonstrates a more positive onset potential and half-wave potential in ORR tests compared to other counterparts owing to its higher nitrogen-doping content and specific surface area. When applied as the cathode material in an actual zinc-air battery, TBGY-800 exhibits remarkable power density (138.6 mW cm–2) and specific capacity (636.6 mAh g–1). This work brings new insight for the rational design of nitrogen-rich carbon materials for electrocatalytic applications

    DataSheet1_Efficacy and safety of eight types Salvia miltiorrhiza injections in the treatment of unstable angina pectoris: A network meta-analysis.docx

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    Background:Salvia miltiorrhiza Bunge. [Lamiaceae, danshen] injection classes (SMIC) is widely used in the treatment of unstable angina (UA). However, it is uncertain which SMIC is more effective in terms of UA efficacy. The purpose of this Network Meta-analysis (NMA) was to compare the treatment effects of various SMIC to determine the best SMIC for the treatment of UA.Methods: The China National Knowledge Infrastructure (CNKI), Wanfang Database, China Science and Technology Journal Database (VIP), Chinese Biomedical Literature Database (CBM), PubMed, Web of Science, and Cochrane Library databases were searched to screen randomized controlled trials (RCTs) of SMIC for UA. The search time frame was all from the establishment of the database to May 2022. RevMan 5.3 and Stata 14.0 software were used for NMA.Results: A total of 148 studies including 14,979 patients, including 7,584 cases in the experimental group and 7,395 cases in the control group were included, and eight SMIC were extracted, namely:Danshen injection, Fufang Danshen injection, Guanxinning injection, Danshenchuanxiongqin injection, Danhong injection, Danshentong IIA Huangsuanna injection, Shenxiong Putaotang injection, and Danshenduofensuanyan injection. The results of NMA showed that, in terms of total effective rate, Shenxiong Putaotang injection and Danshenchuanxiongqin injection have the advantage; In terms of ECG efficiency, Danshentong IIA Huangsuanna injection and Danshen injection have an advantage; Danshenchuanxiongqin injection and Danshenduofensuanyan injection were more effective than other SMIC in improving angina pectoris attacks; Shenxiong Putaotang injection has an advantage in improving hs-CRP; Shenxiong Putaotang injection and Danshentong IIA Huangsuanna injection have advantages in improving TC and TG, respectively.Conclusion: The eight SMIC included in the current study were effective in treating UA, Shenxiong Putaotang injection and Danshentong IIA Huangsuanna injection were both superior in improving all outcome indicators. However, there is still a need for larger samples and high-quality randomized controlled trials for more refined comparisons of various SMIC.Systematic Review Registration: [PROSPERO], identifier [CRD42022350872]</p

    Synthesis of 3‑Substituted 2‑Aminochromones via Sn(IV)-Promoted Annulation of Ynamides with 2‑Methoxyaroyl Chlorides

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    A Sn­(IV)-promoted annulation reaction of ynamides is described for the efficient synthesis of 3-substituted 2-aminochromones under mild conditions. This novel method allows for a concomitant construction of C–C and C–O bonds between ynamides and 2-methoxyaroyl chlorides by a tandem Friedel–Crafts acylation/oxo-Michael addition/elimination strategy

    Synthesis of 2‑Amino-1,3,4-oxadiazoles and 2‑Amino-1,3,4-thiadiazoles via Sequential Condensation and I<sub>2</sub>‑Mediated Oxidative C–O/C–S Bond Formation

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    2-Amino-substituted 1,3,4-oxadiazoles and 1,3,4-thiadiazoles were synthesized via condensation of semicarbazide/thiosemicarbazide and the corresponding aldehydes followed by I<sub>2</sub>-mediated oxidative C–O/C–S bond formation. This transition-metal-free sequential synthesis process is compatible with aromatic, aliphatic, and cinnamic aldehydes, providing facile access to a variety of diazole derivatives bearing a 2-amino substituent in an efficient and scalable fashion

    AlCl<sub>3</sub>‑Catalyzed Annulations of Ynamides Involving a Torquoselective Process for the Simultaneous Control of Central and Axial Chirality

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    A highly torquoselective process for simultaneous control of central and axial chirality by the annulation of terminally substituted ynamides with <i>o</i>-quinone methides is reported. In the presence of AlCl<sub>3</sub>, a sequence comprising a [2 + 2] cycloaddition followed by the torquoselective 4Ď€-electrocyclic ring opening and 6Ď€-electrocyclic ring closure leads to highly stereoselective formation of diastereoisomeric 4-amino-2<i>H</i>-chromenes. Terminally unsubstituted ynamides undergo AlCl<sub>3</sub>-catalyzed [4 + 2] cycloaddition with <i>o</i>-quinone methides providing 2-amino-4<i>H</i>-chromenes

    AlCl<sub>3</sub>‑Catalyzed Annulations of Ynamides Involving a Torquoselective Process for the Simultaneous Control of Central and Axial Chirality

    No full text
    A highly torquoselective process for simultaneous control of central and axial chirality by the annulation of terminally substituted ynamides with <i>o</i>-quinone methides is reported. In the presence of AlCl<sub>3</sub>, a sequence comprising a [2 + 2] cycloaddition followed by the torquoselective 4Ď€-electrocyclic ring opening and 6Ď€-electrocyclic ring closure leads to highly stereoselective formation of diastereoisomeric 4-amino-2<i>H</i>-chromenes. Terminally unsubstituted ynamides undergo AlCl<sub>3</sub>-catalyzed [4 + 2] cycloaddition with <i>o</i>-quinone methides providing 2-amino-4<i>H</i>-chromenes

    Image1_Tibetan medicine salidroside improves host anti-mycobacterial response by boosting inflammatory cytokine production in zebrafish.TIFF

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    The treatment for tuberculosis (TB), especially multidrug-resistant TB (MDR-TB), has a prolonged cycle which can last up to a year. This is partially due to the lack of effective therapies. The development of novel anti-TB drugs from the perspective of host immune regulation can provide an important supplement for conventional treatment strategies. Salidroside (SAL), a bioactive component from the Tibetan medicine Rhodiola rosea, has been used in the treatment of TB, although its mechanism remains unclear. Here, the bacteriostatic effect of SAL in vivo was first demonstrated using a zebrafish–M. marinum infection model. To further investigate the underlying mechanism, we then examined the impact of SAL on immune cell recruitment during wound and infection. Increased macrophage and neutrophil infiltrations were found both in the vicinity of the wound and infection sites after SAL treatment compared with control, which might be due to the elevated chemokine expression levels after SAL treatment. SAL treatment alone was also demonstrated to improve the survival of infected zebrafish larvae, an effect that was amplified when combining SAL treatment with isoniazid or rifampicin. Interestingly, the reduced bacterial burden and improved survival rate under SAL treatment were compromised in tnfα-deficient embryos which suggests a requirement of Tnfα signaling on the anti-mycobacterial effects of SAL. In summary, this study provides not only the cellular and molecular mechanisms for the host anti-mycobacterial effects of the Tibetan medicine SAL but also proof of concept that combined application of SAL with traditional first-line anti-TB drugs could be a novel strategy to improve treatment efficacy.</p

    Image3_Tibetan medicine salidroside improves host anti-mycobacterial response by boosting inflammatory cytokine production in zebrafish.TIFF

    No full text
    The treatment for tuberculosis (TB), especially multidrug-resistant TB (MDR-TB), has a prolonged cycle which can last up to a year. This is partially due to the lack of effective therapies. The development of novel anti-TB drugs from the perspective of host immune regulation can provide an important supplement for conventional treatment strategies. Salidroside (SAL), a bioactive component from the Tibetan medicine Rhodiola rosea, has been used in the treatment of TB, although its mechanism remains unclear. Here, the bacteriostatic effect of SAL in vivo was first demonstrated using a zebrafish–M. marinum infection model. To further investigate the underlying mechanism, we then examined the impact of SAL on immune cell recruitment during wound and infection. Increased macrophage and neutrophil infiltrations were found both in the vicinity of the wound and infection sites after SAL treatment compared with control, which might be due to the elevated chemokine expression levels after SAL treatment. SAL treatment alone was also demonstrated to improve the survival of infected zebrafish larvae, an effect that was amplified when combining SAL treatment with isoniazid or rifampicin. Interestingly, the reduced bacterial burden and improved survival rate under SAL treatment were compromised in tnfα-deficient embryos which suggests a requirement of Tnfα signaling on the anti-mycobacterial effects of SAL. In summary, this study provides not only the cellular and molecular mechanisms for the host anti-mycobacterial effects of the Tibetan medicine SAL but also proof of concept that combined application of SAL with traditional first-line anti-TB drugs could be a novel strategy to improve treatment efficacy.</p

    Modifying Role of GSTP1 Polymorphism on the Association between Tea Fluoride Exposure and the Brick-Tea Type Fluorosis

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    <div><p>Background</p><p>Brick tea type fluorosis is a public health concern in the north-west area of China. The association between SNPs of genes influencing bone mass and fluorosis has attracted attention, but the association of SNPs with the risk of brick-tea type of fluorosis has not been reported.</p><p>Objective</p><p>To investigate the modifying roles of GSTP1 rs1695 polymorphisms on this association.</p><p>Methods</p><p>A cross-sectional study was conducted. Brick-tea water was tested by the standard of GB1996-2005 (China). Urinary fluoride was tested by the standard of WS/T 89-2006 (China). Skeletal fluorosis was diagnosed by X-ray, the part we scheduled was forearm, shank, and pelvic, then diagnosed the skeletal fluorosis by the standard of WS/192-2008 (China). Gene polymorphism was tested by Sequenom MassARRAY system.</p><p>Result</p><p>The prevalence rate in different ethnical participants was different: Tibetan individuals had the highest prevalence rate of skeletal fluorosis. There were significant differences in genotype frequencies of GSTP1 Rs1695 among different ethnical participants (p<0.001): Tibetan, Mongolian and Han subjects with homozygous wild type (GSTP1-AA) genotype were numerically higher than Kazakh and Russian subjects (<i>p</i><0.001). Compared to Tibetan participants who carried homozygous A allele of GSTP1 Rs1695, Tibetan participants who carried G allele had a significantly decreased risk of skeletal fluorosis (OR = 0.558 [95% CI, 0.326-0.955]). For Kazakh participants, a decreased risk of skeletal fluorosis among carriers of the G allele was limited to non high-loaded fluoride status (OR = 0. 166 [95% CI, 0.035–0.780] vs. OR = 1.478 [95% CI, 0.866–2.552] in participants with high-loaded fluoride status). Neither SNP-IF nor SNP-age for GSTP1 Rs1695 was observed.</p><p>Conclusion</p><p>The prevalence rate of the brick tea type fluorosis might have ethnic difference. For Tibetan individuals, who had the highest prevalence rate, G allele of GSTP1 Rs1695 might be a protective factor for brick tea type skeletal fluorosis.</p></div
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