Training, Test, and Simulated Data.

<p>DM – Diabetes Mellitus.</p><p>NPDR - non proliferative diabetic retinopathy.</p><p>PDR - proliferative diabetic retinopathy.</p><p>BMI - body mass index.</p><p>A1c = Hemoglobin A1c.</p><p>Values reported as average ± standard deviation, or number (percent).</p><p>P value represents comparison of Test Data to Simulated Data.</p

Statechart model for Diabetic Retinopathy.

<p>DR: Diabetic Retinopathy NPDR: Non-proliferative Diabetic Retinopathy PDR: Proliferative Diabetic Retinopathy PRP: Pan-retinal Photocoagulation.</p

Probability of Agent Advancement.

<p>The sample agent’s probability of DR progression over time.</p

Change in kidney function and the risk of death.

<p>Model 1 adjusted for age, race, gender, diabetes mellitus, hypertension, cardiovascular disease, hyperlipidemia, peripheral artery disease, cerebrovascular disease, chronic lung disease, hepatitis C, HIV, dementia and eGFR at time of cohort entry (T0). Reference group is patients with stable kidney function (eGFR slope).</p

Renal function trajectories.

<p>Renal function trajectories.</p

Flow chart for cohort selection.

<p>Flow chart for cohort selection.</p

Renal function trajectory phenotypes.

<p>Renal function trajectory phenotypes.</p

Association between serum phosphorus and dementia subtypes.

<p>Association between serum phosphorus and dementia subtypes.</p

Spline analyses for the relationship between serum phosphorus and risk of incident dementia with serum phosphorus probability distribution histogram represented in gray bars in the background.

<p>Fig 2a: Overall cohort. Fig 2b: Analysis was restricted to cohort participants with serum phosphorus level >2.5 mg/dl. Fig 2c: Analysis was restricted to cohort participants with serum phosphorus level >4.5 mg/dl.</p

Sensitivity analyses.

<p>Sensitivity analyses.</p