137 research outputs found

    unusual lessons from the past for the post-Soviet market

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    Tectonic and climatic drivers of Asian monsoon evolution.

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    Asian Monsoon rainfall supports the livelihood of billions of people, yet the relative importance of different drivers remains an issue of great debate. Here, we present 30 million-year model-based reconstructions of Indian summer monsoon and South East Asian monsoon rainfall at millennial resolution. We show that precession is the dominant direct driver of orbital variability, although variability on obliquity timescales is driven through the ice sheets. Orographic development dominated the evolution of the South East Asian monsoon, but Indian summer monsoon evolution involved a complex mix of contributions from orography (39%), precession (25%), atmospheric CO2 (21%), ice-sheet state (5%) and ocean gateways (5%). Prior to 15 Ma, the Indian summer monsoon was broadly stable, albeit with substantial orbital variability. From 15 Ma to 5 Ma, strengthening was driven by a combination of orography and glaciation, while closure of the Panama gateway provided the prerequisite for the modern Indian summer monsoon state through a strengthened Atlantic meridional overturning circulation

    Ante- and postmortem tau in autosomal dominant and late-onset Alzheimer\u27s disease

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    Antemortem tau positron emission tomography imaging suggests elevated tau pathology in autosomal dominant versus late-onset Alzheimer\u27s disease at equivalent clinical stages, but does not implicate the specific tau pathologies responsible. Here we made stereological measurements of tau neurofibrillary tangles, neuritic plaques, and neuropil threads and found compared to late-onset Alzheimer\u27s disease, autosomal dominant Alzheimer\u27s disease showed even greater tangle and thread burdens. Regional tau burden resembled that observed in tau imaging of a separate cohort at earlier clinical stages. Finally, our results suggest tau imaging measures total tau burden in Alzheimer\u27s disease, composed predominantly of tangle and thread pathology

    Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

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    Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

    Statistical Mechanics of Horizontal Gene Transfer in Evolutionary Ecology

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    The biological world, especially its majority microbial component, is strongly interacting and may be dominated by collective effects. In this review, we provide a brief introduction for statistical physicists of the way in which living cells communicate genetically through transferred genes, as well as the ways in which they can reorganize their genomes in response to environmental pressure. We discuss how genome evolution can be thought of as related to the physical phenomenon of annealing, and describe the sense in which genomes can be said to exhibit an analogue of information entropy. As a direct application of these ideas, we analyze the variation with ocean depth of transposons in marine microbial genomes, predicting trends that are consistent with recent observations using metagenomic surveys.Comment: Accepted by Journal of Statistical Physic

    (Re)Making Public Campus Art: Connecting the University, Publics and the City

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    Public campus art in the U.K. is predominantly a postwar phenomenon and can be interpreted as artworks situated in university spaces with free access to its audience: any public users — where the multiplicity of such audience defines them as “publics”: communities of interest. Public art’s ontology of “publicness” is complex: what is “public” and who are the “publics”? The local, theme and form of art in “public” space is contested along dualist conceptions of public/private, indoor/outdoor, closed/open, permanent/temporary, decorative/interactive, past/future, space/place, online/offline, and so on and so forth. It may moreover span any material, digital, performative and socially engaged, practice-based work and multimedia beyond more traditional sculptural artworks. This article analyses how public campus art has traditionally related to historic university agendas and campus communities, but has recently provided a platform for far-reaching public engagement beyond the campus, thus reaching new audiences