Additional file 8: of Safety and efficacy of wiping lid margins with lid hygiene shampoo using the “eye brush”, a novel lid hygiene item, in healthy subjects: a pilot study

The criteria for the diagnosis of MGD suggested by a previous report and the International Workshop on Meibomian Gland Dysfunction. (PNG 699 kb

Heatmap of Pearson’s correlation coefficients between all possible combinations of variables in the ZMB00 group.

Pearson’s correlation coefficients were adjusted by multiple regression with the explanatory variables in S1B Table. The asterisk * in this figure indicates a significant correlation between two parameters at pS3C Table. The illustration was created using a commercially available software program (https://cran.r-project.org/web/packages/pheatmap/pheatmap.pdf) [23]. (TIF)</p

Parameters that demonstrated a significant difference at p<0.00068 or p<0.05 between the bifocal and EDOF groups at 10 weeks after surgery on both eyes.

Parameters that demonstrated a significant difference at p<0.00068 or p<0.05 between the bifocal and EDOF groups at 10 weeks after surgery on both eyes.</p

Results of multiple regression analyses for all postoperative parameters of the bifocal (ZMB00) and EDOF (ZXR00V) groups 10 weeks after surgery in both eyes.

For numerical parameters, multiple mixed linear regression or multiple linear regression was applied, and cumulative logistic regression was applied to the spectacle dependence parameters. In the multiple linear regression or cumulative logistic regression, the variables in S1B Table were used as the explanatory variables. For each response variable, the regression coefficient, its 95% confidence interval, and the p value (Wald test) are shown in (A). The original and corrected values (i.e., before and after adjusting with multiple linear regression) of the mean and standard deviation for each numerical parameter and the counts for each categorical parameter (spectacle dependence: never/sometimes/always), regression coefficient, 95% confidence interval, and p value (Wald test) are shown in (B). (XLSX)</p

Additional file 5: of Safety and efficacy of wiping lid margins with lid hygiene shampoo using the “eye brush”, a novel lid hygiene item, in healthy subjects: a pilot study

Supplementary Table for Fig. 8a. (PDF 50 kb

Contrast sensitivity with/without glare in the bifocal/EDOF groups before/10 weeks after bilateral eye surgery.

In the box-and-whisker plots, the bottom of the box indicates the first quartile, and the top of the box indicates the third quartile. The band inside the box represents the median. To highlight suspected outliers, the upper whisker is set as the maximum or the third quartile+ 1.5 × IQR. The lower whisker indicates the minimum or the first quartile-1.5 × IQR. Each parameter was adjusted by multiple linear regression with the explanatory variables in S1B Table. The two-sided Wald test was conducted to evaluate the significance of differences between the two groups, and the significance level was set to 0.0083 after a Bonferroni correction.</p

Significantly different parameters between the bifocal and EDOF groups 10 weeks after bilateral eye surgery.

The line inside the box represents the median. To highlight suspected outliers, the upper whisker is set as the maximum or the third quartile+ 1.5 × IQR. The lower whisker indicates the minimum or the first quartile-1.5 × IQR. Each parameter was adjusted by multiple regression with the explanatory variables in S1B Table. The two-sided Wald test was performed to evaluate the significance of differences between the two groups, and the significance level was set to 0.00068 using a Bonferroni correction. An asterisk * indicates a significant difference between the two groups with p<0.00068. UIVA: uncorrected intermediate visual acuity; UNVA: uncorrected near visual acuity; CNVA: corrected near visual acuity; C: contrast sensitivity; G: contrast sensitivity with glare.</p

Heatmap of Pearson’s correlation coefficients between all possible combinations of variables in the ZXR00V group.

Pearson’s correlation coefficients were adjusted by multiple regression with the explanatory variables in S1B Table. The asterisk * in this figure indicates a significant correlation between two parameters at pS3C Table. The illustration was created using a commercially available software program (https://cran.r-project.org/web/packages/pheatmap/pheatmap.pdf) [23]. (TIF)</p

S3 Table -

Pearson’s correlation coefficients (A) and p values from the correlation analysis conducted with the two-sided t test (B) for all possible combinations of postoperative parameters, which were adjusted by multiple regression with the explanatory variables in S1B Table, in the bifocal (ZMB00) group. The sample size for calculating the correlation coefficients is shown in (C). (XLSX)</p

Additional file 4: of Safety and efficacy of wiping lid margins with lid hygiene shampoo using the “eye brush”, a novel lid hygiene item, in healthy subjects: a pilot study

Supplementary Table for Fig. 6, 7. (PDF 55 kb