547 research outputs found

    Faunal analysis of the historic component at Healy Lake Village site, Interior Alaska

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    Thesis (M.A.) University of Alaska Fairbanks, 2019The historic period in Interior Alaska was a dynamic time that led to many cultural changes for Native Alaskan communities across the state. Starting in the early 1700s, Russian and Euroamerican explorers began interacting with Native Alaskan groups living on the coast and by the end of the 18th century - early 19th century, Interior Alaskan groups were being directly affected. Due to western influences, Native groups, such as the Upper Tanana Athabascans, began to rely on a cash economy, causing them to settle to year-round villages, trade with the Euroamericans for non-local goods (i.e., flour, guns, buttons, glass, and nails), and work on construction projects in order to provide for their families. All of these changes appeared to cause a division between the traditional way of life and the new Euroamerican way of living. Healy Lake Village site (XBD-00020) is a multi-component site with occupations spanning the terminal Pleistocene into the Holocene. It is located approximately 100 miles southeast of present day Fairbanks on the shores of Healy Lake in the Upper Tanana Athabascan territory. The village was a summer fishing camp until ~A.D. 1910; it became a year-round village soon after the construction of a trading post at Healy Lake. The well-preserved faunal remains excavated from the Upper Cultural level (dating to A.D. 1880 - 1946) at Healy Lake Village site provide a significant opportunity to address fundamental questions relating to subarctic hunter-gatherer subsistence economies. This research employs concepts from human behavioral ecology and world-systems theory to address questions relating zooarchaeological patterns in the data in terms of taphonomy, human procurement, and processing decisions, as well as historic period land use strategies and trade practices. In this thesis, I explore the possibility that the residents at Healy Lake Village site were affected by Euroamerican influences, specifically in regards to their subsistence economies. However, the results suggest that hunting practices were not drastically altered. The residents still relied heavily on local game as their primary source of subsistence with minor inclusions of western goods, such as canned meat and flour.Museum of the North Geist Fund, ASUAF Travel Gran

    A guide to processing Kona coffee cherries

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    Measuring well-being: W3 indicators to complement GDP

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    "Numerous people in Germany, including politicians and researchers, believe that the gross domestic product (GDP) is an outdated indicator of a society’s prosperity. Therefore, at the end of 2010, the German Bundestag, the federal parliament, established a study commission (Enquete-Kommission) tasked with developing an alternative to the GDP for measuring growth, prosperity, and quality of life. This commission has now submitted a proposal: to supplement the GDP with nine additional indicators, including a wide range of factors such as the distribution of income, biodiversity, and life expectancy. The ten indicators cover three dimensions of well-being-economy, ecology, and social wealth-and hence are called W3 Indicators. Replacing the gross domestic product by a single alternative index was rejected by the commission, however, since it is not possible to reduce citizens' very different wishes and expectations to "a common denominator". A representative survey of registered voters conducted by DIW Berlin and TNS Infratest shows that citizens consider the indicators proposed by the commission to be important. Respondents ranked preserving "democracy and freedom" as the most relevant indicator and "further increasing life expectancy" as the least relevant. The average per capita income -as an indicator of the gross domestic product- is the second least relevant factor as far as registered voters in Germany are concerned. However, the study also shows that opinions on the importance of different indicators vary widely. Moreover, there are systematic differences in the relevance of various policy areas for different social groups." (author's abstract

    Drug Burden Index is a Modifiable Predictor of 30-Day-Hospitalization in Community-Dwelling Older Adults with Complex Care Needs:Machine Learning Analysis of InterRAI Data

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    BACKGROUND: Older adults (≥ 65 years) account for a disproportionately high proportion of hospitalization and in-hospital mortality, some of which may be avoidable. Although machine learning (ML) models have already been built and validated for predicting hospitalization and mortality, there remains a significant need to optimise ML models further. Accurately predicting hospitalization may tremendously impact the clinical care of older adults as preventative measures can be implemented to improve clinical outcomes for the patient.METHODS: In this retrospective cohort study, a dataset of 14,198 community-dwelling older adults (≥ 65 years) with complex care needs from the Inter-Resident Assessment Instrument database was used to develop and optimise three ML models to predict 30-day-hospitalization. The models developed and optimized were Random Forest (RF), XGBoost (XGB), and Logistic Regression (LR). Variable importance plots were generated for all three models to identify key predictors of 30-day-hospitalization.RESULTS: The area under the receiver operating characteristics curve for the RF, XGB and LR models were 0.97, 0.90 and 0.72, respectively. Variable importance plots identified the Drug Burden Index and alcohol consumption as important, immediately potentially modifiable variables in predicting 30-day-hospitalization.CONCLUSIONS: Identifying immediately potentially modifiable risk factors such as the Drug Burden Index and alcohol consumption is of high clinical relevance. If clinicians can influence these variables, they could proactively lower the risk of 30-day-hospitalization. ML holds promise to improve the clinical care of older adults. It is crucial that these models undergo extensive validation through large-scale clinical studies before being utilized in the clinical setting.</p

    Anticholinergic burden in older women: not seeing the wood for the trees?

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    Objectives: To identify medicines contributing to and describe predictors of anticholinergic burden among community-dwelling older Australian women. Design, setting and participants: Retrospective longitudinal analysis of data from the Australian Longitudinal Study on Women's Health linked to Pharmaceutical Benefits Scheme medicines data from 1 January 2008 to 30 December 2010; for 3694 women born in 1921–1926. Main outcome measures: Anticholinergic burden calculated from Anticholinergic Drug Scale (ADS) scores derived from ADS levels (0 to 3) for all medicines used by each woman, summed over each 6-month period (semester), medicines commonly used by women with high semester ADS scores (defined as 75th percentile of scores). Results: 1126 women (59.9%) used at least one medicine with anticholinergic properties. The median ADS score was 4 or 5 across all semesters. Most anticholinergic medicines used by women who had a high anticholinergic burden (ADS score, = 9) had a low anticholinergic potency (ADS level 1). Increasing age, cardiovascular disease, and number of other medicines used were predictive of a higher anticholinergic burden. Conclusions: A high anticholinergic medicines burden in this group was driven by the use of multiple medicines with lower anticholinergic potency rather than the use of medicines with higher potency. This is a novel and important finding for clinical practice as doctors would readily identify the risk of a high anticholinergic burden for patients using high potency medicines, but may be less likely to identify this risk for users of multiple medicines with low anticholinergic potency

    An efficient urine peptidomics workflow identifies chemically defined dietary gluten peptides from patients with celiac disease

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    Celiac disease (CeD) is an autoimmune disorder induced by consuming gluten proteins from wheat, barley, and rye. Glutens resist gastrointestinal proteolysis, resulting in peptides that elicit inflammation in patients with CeD. Despite well-established connections between glutens and CeD, chemically defined, bioavailable peptides produced from dietary proteins have never been identified from humans in an unbiased manner. This is largely attributable to technical challenges, impeding our knowledge of potentially diverse peptide species that encounter the immune system. Here, we develop a liquid chromatographic-mass spectrometric workflow for untargeted sequence analysis of the urinary peptidome. We detect over 600 distinct dietary peptides, of which ~35% have a CeD-relevant T cell epitope and ~5% are known to stimulate innate immune responses. Remarkably, gluten peptides from patients with CeD qualitatively and quantitatively differ from controls. Our results provide a new foundation for understanding gluten immunogenicity, improving CeD management, and characterizing the dietary and urinary peptidomes.Ministerio de Ciencia e Innovación SAF2017-83700-

    Japanese Sugar Cane as a Forage Crop.

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    28 p

    IL-1α Signaling Is Critical for Leukocyte Recruitment after Pulmonary Aspergillus fumigatus Challenge

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    Aspergillus fumigatus is a mold that causes severe pulmonary infections. Our knowledge of how A. fumigatus growth is controlled in the respiratory tract is developing, but still limited. Alveolar macrophages, lung resident macrophages, and airway epithelial cells constitute the first lines of defense against inhaled A. fumigatus conidia. Subsequently, neutrophils and inflammatory CCR2+ monocytes are recruited to the respiratory tract to prevent fungal growth. However, the mechanism of neutrophil and macrophage recruitment to the respiratory tract after A. fumigatus exposure remains an area of ongoing investigation. Here we show that A. fumigatus pulmonary challenge induces expression of the inflammasome-dependent cytokines IL-1β and IL-18 within the first 12 hours, while IL-1α expression continually increases over at least the first 48 hours. Strikingly, Il1r1-deficient mice are highly susceptible to pulmonary A. fumigatus challenge exemplified by robust fungal proliferation in the lung parenchyma. Enhanced susceptibility of Il1r1-deficient mice correlated with defects in leukocyte recruitment and anti-fungal activity. Importantly, IL-1α rather than IL-1β was crucial for optimal leukocyte recruitment. IL-1α signaling enhanced the production of CXCL1. Moreover, CCR2+ monocytes are required for optimal early IL-1α and CXCL1 expression in the lungs, as selective depletion of these cells resulted in their diminished expression, which in turn regulated the early accumulation of neutrophils in the lung after A. fumigatus challenge. Enhancement of pulmonary neutrophil recruitment and anti-fungal activity by CXCL1 treatment could limit fungal growth in the absence of IL-1α signaling. In contrast to the role of IL-1α in neutrophil recruitment, the inflammasome and IL-1β were only essential for optimal activation of anti-fungal activity of macrophages. As such, Pycard-deficient mice are mildly susceptible to A. fumigatus infection. Taken together, our data reveal central, non-redundant roles for IL-1α and IL-1β in controlling A. fumigatus infection in the murine lung

    Concurrent use of prescription drugs and herbal medicinal products in older adults: A systematic review

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    This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The use of herbal medicinal products (HMPs) is common among older adults. However, little is known about concurrent use with prescription drugs as well as the potential interactions associated with such combinations. Objective Identify and evaluate the literature on concurrent prescription and HMPs use among older adults to assess prevalence, patterns, potential interactions and factors associated with this use. Methods Systematic searches in MEDLINE, PsycINFO, EMBASE, CINAHL, AMED, Web of Science and Cochrane from inception to May 2017 for studies reporting concurrent use of prescription medicines with HMPs in adults (≥65 years). Quality was assessed using the Joanna Briggs Institute checklists. The Evidence for Policy and Practice Information and Co-ordinating Centre (EPPI-Centre) three stage approach to mixed method research was used to synthesise data. Results Twenty-two studies were included. A definition of HMPs or what was considered HMP was frequently missing. Prevalence of concurrent use by older adults varied widely between 5.3% and 88.3%. Prescription medicines most combined with HMPs were antihypertensive drugs, beta blockers, diuretics, antihyperlipidemic agents, anticoagulants, analgesics, antihistamines, antidiabetics, antidepressants and statins. The HMPs most frequently used were: ginkgo, garlic, ginseng, St John’s wort, Echinacea, saw palmetto, evening primrose oil and ginger. Potential risks of bleeding due to use of ginkgo, garlic or ginseng with aspirin or warfarin was the most reported herb-drug interaction. Some data suggests being female, a lower household income and less than high school education were associated with concurrent use. Conclusion Prevalence of concurrent prescription drugs and HMPs use among older adults is substantial and potential interactions have been reported. Knowledge of the extent and manner in which older adults combine prescription drugs will aid healthcare professionals can appropriately identify and manage patients at risk.Peer reviewedFinal Published versio