Supplementary Table 1 from Resveratrol Induces Differentiation Markers Expression in Anaplastic Thyroid Carcinoma via Activation of Notch1 Signaling and Suppresses Cell Growth

PDF file - 44K, Primer sequences for quantitative real-time PCR.</p

Appendix 1 from Under-Representation of Racial Groups in Genomics Studies of Gastroenteropancreatic Neuroendocrine Neoplasms

Structured Queries to PUBMED and EMBASE for Systematic Literature Review of GEP-NEN Genomics Studies.</p

Figure S2 from Under-Representation of Racial Groups in Genomics Studies of Gastroenteropancreatic Neuroendocrine Neoplasms

Comparison of racial group representation in GEP-NEN genomics, cancer genomics, and in the US population per 2020 census data.</p

Supplementary Data S1-S3 from Under-Representation of Racial Groups in Genomics Studies of Gastroenteropancreatic Neuroendocrine Neoplasms

AACR Genie Comparisons (SD.1), STRING Interactions (SD.2), GO Enrichment of STRING data (SD.3)</p

Figure S3 from Under-Representation of Racial Groups in Genomics Studies of Gastroenteropancreatic Neuroendocrine Neoplasms

Composition of Black and White patient cohorts from the AACR GENIE dataset by sequencing assay ID’s, depicted by raw subject numbers (Left) and by % composition (Right). Only sequencing assays that included both Black and White patients were considered.</p

Figure S1 from Under-Representation of Racial Groups in Genomics Studies of Gastroenteropancreatic Neuroendocrine Neoplasms

Assays used to analyze biomolecules in the 16 studies of GEP-NENs that reported patient race.</p

Supplementary Table S1 from Notch1 Signaling Regulates the Aggressiveness of Differentiated Thyroid Cancer and Inhibits SERPINE1 Expression

Sequences of each primer for real-time quantitative PCR</p

Figure S2 from Notch1 Signaling Regulates the Aggressiveness of Differentiated Thyroid Cancer and Inhibits SERPINE1 Expression

Scratch of a gap for wound healing assay was generated and closure of the gap was evaluated 24 hours later in FTC236-Notch1 cells with or without doxycycline treatment. The cells with NICD induction by doxycycline exhibited slower closure of the gap than those without NICD induction. Images were taken immediately after scratching the cultures 0 hr and 24hr later. Representative images at 0 hr and 24 hr are shown in the upper panel. The bar graph represents the average percentage of the gap closure. Each bar represents mean{plus minus} SEM; "Dox" indicates doxycycline; ** indicates p< 0.01; Scale bar:200µm.</p

Figure S4 from Notch1 Signaling Regulates the Aggressiveness of Differentiated Thyroid Cancer and Inhibits SERPINE1 Expression

SERPINE1 expression detected by immunohistochemistry in FTC236-Notch1 xenografts with or without Notch1 induction. (A) and (B). Two representative tumors from the group without Notch1 induction (Dox-); (C) and (D). Two representative tumors from the group with Notch1 induction (Dox+). Weaker staining of SERPINE1 (1+) is shown in the Dox+ tumors compared with 3+ staining in Dox- tumors. "Dox" indicates doxycycline; Scale bar: 50µm.</p

Figure S1 from Notch1 Signaling Regulates the Aggressiveness of Differentiated Thyroid Cancer and Inhibits SERPINE1 Expression

The correlation between age and expression levels of Notch1 in primary DTC samples (A), contra-lateral non-tumor tissues (B) and tissue of benign thyroid disease (C).(A) Scatter plot of negative linear correlation between Notch1 levels and age in primary DTC samples (R = -0.495). (B)-(C) Significant linear correlation was not observed between age and Notch1 levels in the non-tumor tissues or benign thyroid lesions. Pearson's correlation test was used to compute the correlation significance between the 2 variables.</p