Additional file 1: of A novel lncRNA-focus expression signature for survival prediction in endometrial carcinoma

lncRNAs significantly associated with overall survival in univariate Cox regression analyses. (DOC 38 kb

Additional file 1: Table S1. of Discovery and validation of immune-associated long non-coding RNA biomarkers associated with clinically molecular subtype and prognosis in diffuse large B cell lymphoma

Differential expression of lncRNAs between the two major clinically molecular subtypes of DLBCL (ABC and GCB) (p-value < 0.01 and FDR < 0.15). (XLS 42 kb

The np 3243 MELAS mutation: damned if you aminoacylate, damned if you don't.

The np 3243 MELAS mtDNA mutation in tRNA(leu(UUR))has been variously proposed as a loss-of-function or as a gain-of-function mutation, based on apparently contradictory studies in cultured cell lines. A new report describing the molecular effects of the mutation in vivo now mirrors this variability. This should prompt a more systematic re-investigation of cells carrying the mutation, in order to separate primary from secondary and pathogenic from compensatory effects, all of which may contribute to disease phenotype. Nuclear genetic and developmental background, mitochondrial haplotype, and epigenetic effects may all influence the pathological outcome. Defects in both base-modification and aminoacylation of the mutant tRNA could play critical roles