1 research outputs found
Design, Synthesis, and Biological Activities of Novel Coumarin Derivatives as Pesticide Candidates
Food security is an important issue
in the 21st century;
preventing
and controlling crop diseases and pests are the key to solve this
problem. The creation of new pesticides based on natural products
is an important and effective method. Herein, coumarins were selected
as parent structures, and a series of their derivatives were designed,
synthesized, and evaluated for their antiviral activities, fungicidal
activities, and insecticidal activities. We found that coumarin derivatives
exhibited good to excellent antiviral activities against tobacco mosaic
virus (TMV). The antiviral activities of I-1, I-2a, I-4b, II-2c, II-2g, II-3, and II-3b are better than that of ribavirin
at 500 μg/mL. Molecular docking research showed that these compounds
had a strong interaction with TMV CP. These compounds also showed
broad-spectrum fungicidal activities against 14 plant pathogenic fungi.
The EC50 values of I-1, I-2a, I-3c, and II-2d are in the range of 1.56–8.65
μg/mL against Rhizoctonia cerealis, Physalospora piricola, Sclerotinia sclerotiorum, and Pyricularia
grisea. Most of the compounds also displayed good
insecticidal activities against Mythimna separata. Pesticide-likeness analysis showed that these compounds are following
pesticide-likeness and have the potential to be developed as pesticide
candidates. The present work lays a foundation for the discovery of
novel pesticide lead compounds based on coumarin derivatives