Weighted mean AUROC, specificity at 90% sensitivity, and NPV at 2% prevalence for ATB versus all other conditions across all datasets and across only culture-confirmed datasets for each of the 16 gene signatures.

Weighted mean AUROC, specificity at 90% sensitivity, and NPV at 2% prevalence for ATB versus all other conditions across all datasets and across only culture-confirmed datasets for each of the 16 gene signatures.</p

Transcriptome datasets used for comparison of 16 gene signatures for diagnosis of ATB.

Transcriptome datasets used for comparison of 16 gene signatures for diagnosis of ATB.</p

Gene expression signatures compared within this study.

Gene expression signatures compared within this study.</p

Distribution of genes across the signatures included in this study.

Each row represents a gene signature for active tuberculosis diagnosis. Each column represents 1 gene. The number at the end of a signature name represents the number of genes in the given signature. Genes present in only 1 signature are red; those in 2 or more signatures are blue.</p

Comparison of 16 gene signatures for diagnosis of ATB using bivariate meta-analysis.

Comparison of 16 gene signatures for diagnosis of ATB using bivariate meta-analysis.</p

AUROC, PPV, and NPV for progression from LTBI to ATB in the ACS cohort up to 180 days prior to diagnosis.

AUROC, PPV, and NPV for progression from LTBI to ATB in the ACS cohort up to 180 days prior to diagnosis.</p