1 research outputs found
Mutual Induced Fit in a Synthetic Host–Guest System
Mutual
induced fit is an important phenomenon in biological molecular
recognition, but it is still rare in artificial systems. Here we report
an artificial host–guest system in which a flexible calix[4]Âarene
is enclathrated in a dynamic self-assembled host and both molecules
mutually adopt specific three-dimensional structures. NMR data revealed
the conformational changes, and crystallographic studies clearly established
the precise structures at each stage