Qualifikationsspielräume bei Anwendung der Mikroelektronik

"Indem die Mikroelektronik in einer zunehmend größeren Anzahl von Arbeitsprozessen als Arbeitsmittel oder Teil von Arbeitsmitteln angewandt wird, ist sie auch mit verschiedenartigen Formen der Arbeitsorganisation und der Qualifikationsverteilung verbunden. Angesichts dieser Vielgestaltigkeit erhebt sich die Frage, ob auf verschiedene Anwendungsfelder der Mikroelektronik übergreifende Effekte festzustellen sind. Anhand von Ergebnissen sowohl aus dem industriell-verarbeitenden wie aus dem Büro-/Verwaltungsbereich wird gezeigt, daß ähnliche Qualifikationsspielräume über Anwendungsbereiche hinweg bestehen. Die Ausfüllung dieser Spielräume hängt von der Art wirtschaftlich-technischer Strategien ab, die im Unternehmen zur Geltung kommen. Unterschiede zwischen nationalen Systemen der Berufsbildung und der Betriebsleistung werden durch Anwendung neuer Techniken nicht verwischt, sondern bestehen weiter. Technikfolgen werden vor allem durch den Anwendungszusammenhang der Technik bestimmt. Der Anwendungszusammenhang hat sich aber im Zeitablauf aufgrund gesamtwirtschaftlicher Verschiebungen so geändert, daß zumindest ein Aufhalten, wenn nicht ein Umkehren der Tendenz zur Polarisierung von Qualifikationsstrukturen bemerkbar ist." (Autorenreferat)Mikroelektronik, Qualifikationsstruktur, Arbeitsorganisation

Prevention of fraud, corruption and bribery committed through legal entities for the purpose of financial and economic gain

In Dutch law there is no overall criminal offence on corruption. In Dutch criminal law corruption is divided in specific criminal offences which all have their own specific definition. Most corruption can be qualified as a criminal offence but it is sometimes difficult to qualify them as such. Qualifying in general as an offence is easy (forgery for example) but proving that the act specifically qualifies as corruption is harder. Given this general observation, a specific form of active corruption in the Dutch Criminal Code (DCC) seems relevant regarding to art. 2, par. 1, section a of the Framework Decision 2003/568/JHA of 22 July 2003 on combatting corruption in the private sector. Art. 328ter par. 2 of the DCC deals with bribery of a private person: punishable is the private person that gives or offers someone other than a civil servant, working in employement or acting as an agent, in exchange for something he has done or not done or will do or refrain from doing in the performance of his burden, a gift or promise, or a service of that nature or under such circumstances that he should reasonable assume that such a gift or promise will be withheld from his employer or principal contrary to good faith. This provision covers active corruption on the initiative of all private persons, including employees, managers and directors of private entities. However, this provision is limited to the bribery of employees and managers and seems to exclude the bribery of a director of a private entity. This means that this provision does not fully cover the obligation under art. 2, par. 1, section a of the Framework Decision 2003/568/JHA. In addition to art. 328ter DCC more general provisions can be used, especcially when the active corruption involves bribery of a director of a private entity. Dependant upon the circumstances of the case the provisions on forgery, falsifying of documents and cheating could be relevant. These circumstances should then involve: the forgery of a written statement with the intention to use this statement as genuine (art. 225 DCC), the falsification of stock certificates or other official certificates or documents, (art. 226 DCC) or the elements of cheating. In art. 326 of the DCC cheating is described as: the person who intentionally favours himself or another person in a unlawfull way, by using a false name, a false capacity, cunning manouvres or fabrications, moving another person to hand over a good, a service, information or a debt

Long-Term Experience of Chemoradiotherapy Combined with Deep Regional Hyperthermia for Organ Preservation in High-Risk Bladder Cancer (Ta, Tis, T1, T2).

BackgroundThe aim of this study was to evaluate the efficacy and safety of chemoradiotherapy (RCT) combined with regional deep hyperthermia (RHT) of high-risk bladder cancer after transurethral resection of bladder tumor (TUR-BT).Materials and methodsBetween 1982 and 2016, 369 patients with pTa, pTis, pT1, and pT2 cN0-1 cM0 bladder cancer were treated with a multimodal treatment after TUR-BT. All patients received radiotherapy (RT) of the bladder and regional lymph nodes. RCT was administered to 215 patients, RCT + RHT was administered to 79 patients, and RT was used in 75 patients. Treatment response was evaluated 4-6 weeks after treatment with TUR-BT.ResultsComplete response (CR) overall was 83% (290/351), and in treatment groups was RT 68% (45/66), RCT 86% (178/208), and RCT + RHT 87% (67/77). CR was significantly improved by concurrent RCT compared with RT (odds ratio [OR], 2.32; 95% confidence interval [CI], 1.05-5.12; p = .037), less influenced by hyperthermia (OR, 2.56; 95% CI, 0.88-8.00; p = .092). Overall survival (OS) after RCT was superior to RT (hazard ratio [HR], 0.7; 95% CI, 0.50-0.99; p = .045). Five-year OS from unadjusted Kaplan-Meier estimates was RCT 64% versus RT 45%. Additional RHT increased 5-year OS to 87% (HR, 0.32; 95% CI, 0.18-0.58; p = .0001). RCT + RHT compared with RCT showed a significantly better bladder-preservation rate (HR, 0.13; 95% CI, 0.03-0.56; p = .006). Median follow-up was 71 months. The median number of RHT sessions was five.ConclusionThe multimodal treatment consisted of a maximal TUR-BT followed by RT; concomitant platinum-based chemotherapy combined with RHT in patients with high-grade bladder cancer improves local control, bladder-preservation rate, and OS. It offers a promising alternative to surgical therapies like radical cystectomy.Implications for practiceRadical cystectomy with appropriate lymph node dissection has long represented the standard of care for muscle-invasive bladder cancer in medically fit patients, despite many centers reporting excellent long-term results for bladder preserving strategies. This retrospective analysis compares different therapeutic modalities in bladder-preservation therapy. The results of this study show that multimodal treatment consisting of maximal transurethral resection of bladder tumor followed by radiotherapy, concomitant platinum-based chemotherapy combined with regional deep hyperthermia in patients with Ta, Tis, T1-2 bladder carcinomas improves local control, bladder-preservation rate, and survival. More importantly, these findings offer a promising alternative to surgical therapies like radical cystectomy. The authors hope that, in the future, closer collaboration between urologists and radiotherapists will further improve treatments and therapies for the benefit of patients

Yang-Lee and Fisher Zeros of Multisite Interaction Ising Models on the Cayley-type Lattices

A general analytical formula for recurrence relations of multisite interaction Ising models in an external magnetic field on the Cayley-type lattices is derived. Using the theory of complex analytical dynamics on the Riemann sphere, a numerical algorithm to obtain Yang-Lee and Fisher zeros of the models is developed. It is shown that the sets of Yang-Lee and Fisher zeros are almost always fractals, that could be associated with Mandelbrot-like sets on the complex magnetic field and temperature planes respectively.Comment: 9 pages, 3 figures; with minor correction

KPNA2 protein expression in invasive breast carcinoma and matched peritumoral ductal carcinoma in situ

The aim of this study was to evaluate protein expression of Karyopherin alpha 2 (KPNA2) in invasive breast cancer and matched ductal carcinoma in situ (DCIS) and to correlate it with clinicopathological data, including patient survival. KPNA2 protein expression was assessed by immunohistochemistry in breast tissue samples, containing invasive carcinomas, DCIS, and adjacent histologically benign breast tissues. A polyclonal goat KPNA2 antibody was used for immunostaining of 83 clinicopathologically characterized cases. For statistical analysis, staining of at least 10% of nuclei was considered KPNA2 positive. Immunohistochemical detection of KPNA2 in invasive carcinoma showed a significant correlation with higher tumor stage, positive lymph node status, higher tumor grade, and negative ER status. Concordantly, KPNA2-positive tumors (31.3%) showed significantly shorter disease-free survival times (69months vs 118months; p = 0.007). KPNA2 protein expression was also detected in DCIS (21.3%) adjacent to invasive tumor and correlated with nuclear grade (p = 0.013). Expression of KPNA2 in invasive breast cancer correlates with conventional prognostic parameters and shorter disease-free survival. Additionally, KPNA2 is overexpressed in DCIS, particularly high grade lesions, which emphasizes its potential role in carcinogenesis of invasive breast carcinoma

Diagnostics and prognostic evaluation in renal cell tumors: the German S3 guidelines recommendations

The German guidelines on renal cell carcinoma (RCC) have been developed at highest level of evidence based on systematic literature review. In this paper, we are presenting the current recommendations on diagnostics including preoperative imaging and imaging for stage evaluation as well as histopathological classification. The role of tumor biopsy is further discussed. In addition, different prognostic scores and the status of biomarkers in RCC are critically evaluated

Lineshape of the Lambda(1405) Hyperon Measured Through its Sigma0 pion0 Decay

The pp -> p K+ Y0 reaction has been studied for hyperon masses m(Y0)<1540 MeV/c2 at COSY-Juelich by using a 3.65 GeV/c circulating proton beam incident on an internal hydrogen target. Final states comprising two protons, one positively charged kaon and one negatively charged pion have been identified with the ANKE spectrometer. Such configurations are sensitive to the production of the ground state Lambda and Sigma0 hyperons as well as the Sigma0(1385) and Lambda(1405) resonances. Applying invariant- and missing-mass techniques, the two overlapping excited states could be well separated, though with limited statistics. The shape and position of the Lambda(1405) distribution, reconstructed cleanly in the Sigma0 pion0 channel, are similar to those found from other decay modes and there is no obvious mass shift. This finding constitutes a challenging test for models that predict Lambda(1405) to be a two-state resonance.Comment: 10 pages, 4 figures, accepted for publication in Phys. Lett.

Immunophenotyping and oncogene amplifications in tumors of the papilla of Vater

Carcinomas of the ampulla of Vater are rare and assumed to generally arise from preexisting adenomas (adenoma-carcinoma sequence). Histologically, distinct subtypes can be distinguished that were shown to differ significantly in terms of clinical outcome. Since pathologists usually receive bioptic tissue samples of ampullary tumors obtained during endoscopy, accurate classification of carcinoma subtypes can sometimes be difficult on morphological criteria alone. We therefore performed immunohistochemistry using a panel of established marker proteins (CK7, CK20, p21, p27, ESA, bax, and ephrin-B2) on 175 carcinoma, 111 adenoma, and 152 normal mucosa specimens of the ampulla of Vater and identified distinct immunoprofiles for every carcinoma subtype. Fluorescence in situ hybridization analyses of therapeutic target genes (c-myc, EGFR1, CCND1, HER2) found CCND1 to represent the most frequently amplified gene in our series (7.5%

Экструдируемые гетеромодульные полимер-полимерные композиты на основе сверхвысокомолекулярной матрицы

Purpose:The aim of the present study was to define gene expression profiles of noninvasive and invasive bladder cancer, to identify potential therapeutic or screening targets in bladder cancer, and to define genetic changes relevant for tumor progression of recurrent papillary bladder cancer (pTa). Experimental Design: Overall, 67 bladder neoplasms (46 pTa, 3 pTis, 10 pT1, and 8 pT2) and eight normal bladder specimens were investigated by a combination of laser microdissection and gene expression profiling. Eight of 16 patients with recurrent noninvasive papillary bladder tumors developed carcinoma in situ (pTis) or invasive bladder cancer (>= pT1G2) in the course of time. RNA expression results of the putative progression marker cathepsin E (CTSE) were confirmed by immunohistochemistry using high-throughput tissue microarray analysis (n = 776). Univariate analysis of factors regarding overall survival, progression-free survival, and recurrence-free survival in patients with urothelial bladder cancer was done. Results: Hierarchical cluster analyses revealed no differences between pTaG1 and pTaG2 tumors. However, distinct groups of invasive cancers with different gene expression profiles in papillary and solid tumors were found. Progression-associated gene profiles could be defined (e.g., FABP4 and CTSE) and were already present in the preceding noninvasive papillary tumors. CTSE expression (P = 0.003) and a high Ki-67 labeling index of at least 5% (P = 0.01) were the only factors that correlated significantly with progression-free survival of pTa tumors in our gene expression approach. Conclusions: Gene expression profiling revealed novel genes with potential clinical utility to select patients that are more likely to develop aggressive disease