Unsupervised learning based fast beamforming design for downlink MIMO

In the downlink transmission scenario, power allocation and beamforming design at the transmitter are essential when using multiple antenna arrays. This paper considers a multiple input-multiple output broadcast channel to maximize the weighted sum-rate under the total power constraint. The classical weighted minimum mean-square error (WMMSE) algorithm can obtain suboptimal solutions but involves high computational complexity. To reduce this complexity, we propose a fast beamforming design method using unsupervised learning, which trains the deep neural network (DNN) offline and provides real-time service online only with simple neural network operations. The training process is based on an end-to-end method without labeled samples avoiding the complicated process of obtaining labels. Moreover, we use the ’APoZ’-based pruning algorithm to compress the network volume, which further reduces the computational complexity and volume of the DNN, making it more suitable for low computation-capacity devices. Finally, experimental results demonstrate that the proposed method improves computational speed significantly with performance close to the WMMSE algorithm

Data_Sheet_1_The association between dietary fiber intake and severe headaches or migraine in US adults.docx

BackgroundThe data on the effect of dietary fiber on severe headaches or migraine are limited. Therefore, this study aimed to investigate the association between dietary fiber intake and the prevalence of severe headaches or migraine.MethodsWe conducted a cross-sectional study involving 12,710 participants, all data collected from NHANES 1999–2004. A multivariable logistic regression model was used to analyze the relationship between dietary fiber intake (as an independent variable) and severe headaches or migraine (as outcome variable). We also performed sensitivity analyses, including multiple sensitivity analyses.ResultsThe overall incidence of severe headache or migraine in the study was 2527/12,710 (19.9%). After adjusting for correlation covariates, we found a significant inverse association between dietary fiber intake and severe headache or migraine, with lowest prevalence in the fifth quintile (OR: 0.74, 95% CI: 0.61–0.90). Our study also revealed that for every 10 g/day increase in dietary fiber intake, the prevalence of severe headache or migraine decreased by 11%. However, no such inverse association was found among Mexican Americans, other races, or those with a body mass index (BMI) of 25–30. E-value analysis suggested robustness to unmeasured confounding.ConclusionIncreasing the intake of fiber-rich foods might protect from severe headache or migraine. More prospective studies should be conducted to confirm their association before dietary recommendations.</p

Structural Basis for the Activation of Platelet Integrin αIIbβ3 by Calcium- and Integrin-Binding Protein 1

Calcium and integrin binding protein 1 (CIB1) is a specific binding partner for the cytoplasmic domain of the αIIb subunit of the highly abundant platelet integrin αIIbβ3. This protein has been suggested to be involved in the regulation of the activation of αIIbβ3, a process leading to platelet aggregation and blood coagulation. In this work, the solution structure of the deuterated Ca²⁺-CIB1 protein complexed with an αIIb peptide was first determined through modern RDC-based NMR methods. Next, we generated a complex structure for CIB1 and the αIIb domain (Ca²⁺-CIB1/αIIb) using the program Haddock, which is based on experimental restraints obtained for the protein–peptide interface from cross-saturation NMR experiments. In this data-driven complex structure, the N-terminal α-helix of the cytoplasmic domain of αIIb is buried in the hydrophobic pocket of the C-lobe of Ca²⁺-CIB1. The C-terminal acidic tail of αIIb remains unstructured and likely interacts with several positively charged residues in the N-lobe of Ca²⁺-CIB1. A potential molecular mechanism for the CIB1-mediated activation of the platelet integrin could be proposed on the basis of the model structure of this protein complex. Another feature of this work is that, in the NMR cross-saturation experiments, we applied the selective radio frequency irradiation to the smaller binding partner (the αIIb peptide), and successfully detected the binding interface on the larger binding partner Ca²⁺-CIB1 through its selectively protonated methyl groups. This ‘reverse’ methodology has a broad potential to be employed to many other complexes where synthetic peptides and a suitably isotope-labeled medium- to large-sized protein are used to study protein–protein interactions

Putative QTLs for growth-related traits in <i>L</i><i>. vannamei</i>.

<p>QTLs, Quantitative trait loci.</p

New linkage map in <i>L</i><i>. vannamei</i> based on AFLP and SSR markers.

<p>Marker names are shown on the right and the adjacent marker spacing is displayed on the left in Kosambi centimorgans (cM). AFLP markers are in plain typeface and SSR markers are in bold.</p

Fabrication of silicone foam/polytitanosiloxane composite with enhanced flame retardancy

In this research, a series of silicone foam/polytitanosiloxane composites (SF-pTS) were fabricated with hydroxy-, vinyl-, hydrogen-containing polydimethylsiloxanes, and polytitanosiloxane filler in the presence of a platinum catalyst under ambient conditions. The effect of the amount of polytitasiloxane on the micromorphology and flame retardancy of silicone foam was studied, and a relative flame retardancy mechanism was proposed. It could be found that the polytitanosiloxane exhibited a good dispersion level in the silicone foam, thus improving the flame retardancy of the composite. When the content of polytitanosiloxane is 9 wt%, the limiting oxygen index and UL-94 grade of the SF-pTS9 composite are increased to 29.2% and FV-0, respectively. Cone experiment results suggested that the SF-pTS9 possessed relative balanced PHRR (148.9 kW/m2), THR (58.5 MJ/m2), TSP (0.6 m2), and mass residue (83.9%) among the prepared silicone foam materials. This work provides a new avenue to fabricate a silicone foam composite with enhanced flame retardancy.</p

Table1_Case report: A novel heterozygous frameshift mutation of ACAN in a Chinese family with short stature and advanced bone age.DOCX

Short stature (OMIM: 165800) is a common pediatric disorder. Any abnormality in the cartilage formation of the growth plate can cause short stature. Aggrecan, encoded by ACAN, is an important component of the extracellular matrix. Mutations in ACAN have been reported to cause short stature. In the present study, we enrolled a Chinese family with short stature and advanced bone age across three generations. Whole-exome sequencing (WES) was performed on the proband to detect the candidate genes causing short stature in family. A novel heterozygous frameshift mutation (NM_013227.3:c.7230delT; NP_001356197.1: p. Phe2410Leufs*9) of the ACAN gene was confirmed to be a genetic lesion in this family. This variant, which was located in a functional site globular 3 (G3) domain of ACAN and predicted to be deleterious by informatics programs, was co-segregated with the affected family members by performing Sanger sequencing. Literatures review of growth hormone (GH) treatment outcome of all previously reported ACAN patients suggesting that the G3 domain of ACAN may be critical in the development of short stature and growth hormone treatment. These findings not only contribute to the genetic diagnosis and counseling of the family, but will also expand the mutation spectrum of ACAN.</p

Thermolytical Entrapment of Ultrasmall MoC Nanoparticles into 3D Frameworks of Nitrogen-Rich Graphene for Efficient Oxygen Reduction

In our efforts to obtain Pt-free oxygen reduction reaction (ORR) electrocatalysts with high efficiency for fuel cell and metal–air battery, design, and preparation of novel materials with desired morphology and active sites are vitally necessary. Herein, a novel MoC-based ORR catalyst with high efficiency is achieved. The proposed catalyst is comprised of ultrasmall-sized MoC nanoparticles (average size ∼ 1.5 nm) entrapped into 3D porous frameworks of N-rich graphene (NGr), which is synthesized by using layered C₃N₄ as a sacrificial template via a facile pyrolytic approach. Possessing unique structural features (including preferential O₂ absorbing sites, good accessibility, favorable conductive and protective 3D frameworks of NGr), the MoC/NGr catalyst exhibits positive onset- and peak- potential at 0.93 and 0.80 V for ORR in alkaline media with good four-electron selectivity (<i>n</i> ≈ 4.0), which is promising and even competitive to commercial Pt/C, particularly in terms of cost-effectiveness, the ease of preparation, significantly improved methanol tolerance, and enhanced stability. Other prospective application of MoC/NGr could also be broadened to biomimic catalysis, energy conversion, storage devices, and so on

Pretargeted Immuno-PET Based on Bioorthogonal Chemistry for Imaging EGFR Positive Colorectal Cancer

Pretargeted immuno-PET imaging based on the bioorthogonal chemistry between ¹⁸F-labeled Reppe anhydride derivatives and tetrazine conjugates of the EGFR-specific monoclonal antibodies cetuximab and panitumumab was performed. This pretargeting approach yielded high target-to-nontarget ratios. Furthermore, due to the fast clearance rate of the PET probe, the overall radiation burden to nontarget tissues was also substantially decreased

Probing Polymer–Pendant Interactions in the Conducting Redox Polymer Poly(pyrrol-3-ylhydroquinone)

Conducting polymers with redox active pendant groups show properties typical of both conducting polymers (i.e., capacitive charging and intrinsic conductivity) and redox polymers (i.e., electrochemical surface response at the formal potential of the pendant groups). The two components can also exert significant interaction on each other during their separate electrochemical reactions. In poly­(pyrrol-3-ylhydroquinone), a polypyrrole derivative functionalized with hydroquinone units, the redox conversion of the pendant groups has a large impact on the polymer backbone. This interaction is manifested by a loss of bipolaron states during the hydroquinone oxidation, leading to a decreasing p-doping level with increasing potential, something which, to the best of our knowledge, has never been observed for a conducting polymer. Another effect is a contraction of the polymer film, and subsequent mass loss due to solvent expulsion upon hydroquinone oxidation, which counteracts the normal swelling of polypyrrole with increased potential. The conducting redox polymer under investigation has been synthesized via two routes, leading to different fractions of subunits bearing redox active hydroquinone groups. While the redox potentials are unaffected by the synthesis route, the backbone/pendant group interaction varies notably depending on the degree of quinone functionalization. This type of polymers could find use in, e.g., organic energy storage materials, since the polymer backbone both increases the electronic conductivity and prevents dissolution of the active material, as well as in actuator application, due to polymer contraction over the relatively narrow potential region where the pendant group redox chemistry occurs