Inland China : A Sustainable Tourism Development Framework

Description to be added</p

Dataset-J of Ecology-Zilong

These data were collected in a boreal forest of Canad

A Novel Stereocontrolled Synthesis of 1,2-<i>trans</i> Cyclopropyl Ketones via Suzuki-Type Coupling of Acid Chlorides with Cyclopropylboronic Acids

The palladium-catalyzed cross-coupling reaction of cyclopropylboronic acids with acyl chlorides was achieved by the combination of Ag2O and K2CO3 as the base. Highly enantiomerically enriched cyclopropyl ketones (ee >90%) were also obtained by the reaction of corresponding chiral cyclopropylboronic acids

Distribution of average numbers of non-zero IBD sharing per individual in local IBD matrices.

For each color, a total of 3,403 local IBD matrices of sample size N = 487,252 for 1 cM windows were plotted, with density estimates scaled to maximum of 1. The local IBD matrices were constructed from RaPID and hap-IBD IBD segments called with length ≥ 3 cM, 5 cM, 10 cM.</p

Power comparison of FiMAP and GWAS.

(A) Untyped rare causal variants, 1 cM causal window; (B) Untyped rare causal variants, 1 cM neighboring windows; (C) Haplotype effects, 1 cM causal window; (D) Haplotype effects, 1 cM neighboring windows. In each simulation replicate, finite-sample FiMAP with local IBD matrices constructed from RaPID and hap-IBD IBD segments called with length ≥ 3 cM, 5 cM, 10 cM were benchmarked with a GWAS single-variant test. Empirical power was estimated for FiMAP as the proportion of finite-sample p values less than 0.05/3,403 = 1.47 × 10−5, and for GWAS as the proportion of any minimum single-variant p values in each 1 cM testing window less than 5 × 10−8, over 1,000 simulation replicates.</p

Proportions of power simulation replicates in which both FiMAP and GWAS or only one approach identified the association.

Proportions of power simulation replicates in which both FiMAP and GWAS or only one approach identified the association.</p

GWAS and finite-sample FiMAP p values from RaPID IBD segments on chromosome 16.

(A) Waist circumference; (B) Hip circumference; (C) Body mass index; (D) Body weight. IBD segments called by RaPID with length ≥ 3 cM were used in the FiMAP analysis. GWAS p values were shown in grey and unconditional FiMAP p values were shown in orange. GWAS p values −25 were truncated at 1 × 10−25. For windows with unconditional FiMAP p values −5, conditional p values after adjusting for all tag variants in each conditional set were shown in blue triangles. (TIF)</p

Numbers of significant 1 cM windows in UK Biobank unconditional and conditional IBD mapping for 6 anthropometric traits.

Numbers of significant 1 cM windows in UK Biobank unconditional and conditional IBD mapping for 6 anthropometric traits.</p

FiMAP analysis results for body mass index in the UK Biobank.

Start and end positions in centimorgan (cM) are shown, along with the number of non-zero off-diagonal elements in each N × N local IBD matrix and finite-sample p values (N = 407,255). (XLSX)</p

FiMAP analysis results for standing height in the UK Biobank.

Start and end positions in centimorgan (cM) are shown, along with the number of non-zero off-diagonal elements in each N × N local IBD matrix and finite-sample p values (N = 407,681). (XLSX)</p